Patents by Inventor Marvin J. Weinstein

Marvin J. Weinstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extraction of interferon from bacteria
    Patent number: 4364863
    Abstract: A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, separating the interferon containing liquid from the suspended cells, and extracting the interferon from said liquid.
    Type: Grant
    Filed: February 2, 1982
    Date of Patent: December 21, 1982
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Marvin J. Weinstein
  • Antibiotic 67-121, a new polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4359462
    Abstract: A microorganism of the genus Acetinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: May 14, 1980
    Date of Patent: November 16, 1982
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Extraction of interferon from bacteria
    Patent number: 4315852
    Abstract: A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, separating the interferon containing liquid from the suspended cells, and extracting the interferon from said liquid.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: February 16, 1982
    Assignee: Schering Corporation
    Inventors: Paul Leibowitz, Marvin J. Weinstein
  • Method for producing rosaramicin (rosamicin)
    Patent number: 4234690
    Abstract: Rosaramicin, (also known as rosaramicin) a new broad spectrum antibiotic is described together with methods for its production via the cultivation under controlled conditions of Micromonospora rosaria, a new species of Micromonospora, and to methods for purifying and using the same. Its 2'-monoesters and its 3,2'-diesters and their acid addition salts also possess antibiotic activity.
    Type: Grant
    Filed: July 16, 1979
    Date of Patent: November 18, 1980
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic W-10 complex, antibiotic 20561 and antibiotic 20562 as antifungal agents
    Patent number: 4232006
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotic W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: November 4, 1980
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom
    Patent number: 4230799
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotoc W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: October 28, 1980
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Antibiotic 67-121, a polyene antifungal antibiotic produced by Actinoplanes caeruleus
    Patent number: 4223130
    Abstract: A microorganism of the genus Actinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: September 16, 1980
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Rosamicin esters, acid addition salts and methods for production thereof
    Patent number: 4161523
    Abstract: Antibiotic 67-694, (also known as rosamicin) a new broad spectrum antibiotic is described together with methods for its production via the cultivation under controlled conditions of Micromonospora rosaria, a new species of Micromonospora, and to methods for purifying and using the same. Its 2'-monoesters and its 3,2'-diesters and their acid addition salts also possess antibiotic activity.
    Type: Grant
    Filed: October 21, 1974
    Date of Patent: July 17, 1979
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Process for the preparation of antibiotic W-10 complex and for the isolation of antibiotic 20561 and antibiotic 20562 therefrom
    Patent number: 4137224
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotic W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: February 9, 1977
    Date of Patent: January 30, 1979
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Antibiotic complex from micromonospora arborensis
    Patent number: 4078056
    Abstract: Micromonospora arborensis produces a plurality of antibiotics named herein antibiotic 68-1147 complex, when cultivated under controlled aerobic conditions. Two of the antibiotics, antibiotic 68-1147 I and antibiotic 68-1147 II are described and shown to be effective antibacterial agents, especially against gram positive bacteria.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Raymond T. Testa
  • Antibiotic 67-121, a polyene antifungal antibiotic produced by actinoplanes caeruleus
    Patent number: 4027015
    Abstract: A microorganism of the genus Actinoplanes produces a novel complex of polyene antibiotics herein designated collectively Antibiotic 67-121 (and sometimes referred to as the Antibiotic 67-121 complex). The individual components are designated Antibiotic 67-121A, Antibiotic 67-121B, Antibiotic 67-121C and Antibiotic 67-121D. The individual components have ultraviolet spectra characteristic of heptaenes. Further, they are orally active against a variety of strains of Candida albicans including many clinical isolates thereof.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: May 31, 1977
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Mahesh G. Patel
  • Semi-synthetic aminocyclitol aminoglycoside antibiotics and methods for the preparation thereof
    Patent number: 4011390
    Abstract: Micromonospora inyoensis strain 1550F-1G NRRL 5742 is incapable of producing antibiotics unless an aminocyclitol is added to the fermentation medium. When such a compound is added, mutamicins are produced, said mutamicins being analogs of known aminoglycoside antibiotics differing therefrom with respect to the aminocyclitol subunit.
    Type: Grant
    Filed: June 5, 1974
    Date of Patent: March 8, 1977
    Assignee: Schering-Plough Corporation
    Inventors: Marvin J. Weinstein, Peter J. L. Daniels, Gerald H. Wagman, Raymond Testa
  • Antibiotic G-52 and method for the production thereof
    Patent number: 4001209
    Abstract: A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods for producing, isolating and using the antibiotics.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: January 4, 1977
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic G-418 and the production thereof
    Patent number: 3997403
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: October 10, 1975
    Date of Patent: December 14, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antibiotics sisomicin and verdamicin I and complex containing same
    Patent number: 3988316
    Abstract: A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of which Verdamicin I is a novel basic antibiotic possessing a broad antibacterial spectrum. The other components have been produced previously.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: October 26, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Antibiotic G-418 and the production thereof
    Patent number: 3959254
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: November 8, 1973
    Date of Patent: May 25, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antibiotic G-52 and method for the production thereof
    Patent number: 3956068
    Abstract: A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods for producing, isolating and using the antibiotics.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: May 11, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez
  • Actinomycin complex from micromonospora
    Patent number: 3954970
    Abstract: An antibiotic complex consisting of about 25 components herein designated antibiotic 70591 complex is produced by Micromonospora floridensis, a novel microorganism. The antibiotic complex has been classified as an actinomycin and has been found to exhibit a broad spectrum of antibacterial activity.
    Type: Grant
    Filed: May 24, 1974
    Date of Patent: May 4, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Paul D. Watkins
  • Antibiotics and process for their manufacture
    Patent number: 3951746
    Abstract: A novel composition having antibiotic activity is produced by fermentation of the new species of microorganism, Micromonospora grisea. The antibiotic complex is composed of four components, Verdamicin I, sisomicin, Antibiotic G-418, and gentamicin A, of which Verdamicin I is a novel basic antibiotic possessing a broad antibacterial spectrum. The other components have been produced previously.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: April 20, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez