Abstract: Therapeutic polypeptides, compositions thereof and methods of use thereof for activating NK cells and treating tumors are provided. The therapeutic polypeptides can include a first domain for binding NKG2D and a second domain for binding a tumor target.

Abstract: Compositions and methods for treatment of autoimmune and inflammatory conditions which include Orthopox Major Histocompatibility complex (MHC) class I-like protein (OMCP) or a variant thereof.

Abstract: A photo-medicine device may include a housing having: a mounting member and an application member including an aperture. An LED array having at least one LED configured to emit light through the aperture at a first wavelength and at least one LED configured to emit light through the aperture at a second wavelength may be mounted to the mounting member. The LED array may be in thermal communication with the mounting member such that the housing functions as a heat sink for the LED array. In some embodiments, the first wavelength comprises approximately 415 nm and the second wavelength comprises approximately 660 nm. In some embodiments, the housing has a heat dissipation surface area of at least three square inches per LED watt.

Abstract: A foot-operated control system for use with a multi-function device includes a movable foot control device, one embodiment of the device comprising a pedal mounted on a base to pivot azimuthally with respect to the base and also downwardly in elevation with respect to the base. When the pedal is pivoted in azimuth, the foot control device provides selection signals to a selector including a function menu. The selector in turn, selects a menu segment from the function menu which corresponds to the desired function of the multi-function device. Pivoting the pedal to the left or to the right moves a menu indicator or icon through the various menu segments until the indicator indicates the segment corresponding to the desired function as indicated. The foot pedal is then returned to a central position and is moved in elevation to actuate the multi-function device to perform the selected function.