Patents by Inventor Marvin Whiteley

Marvin Whiteley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic lipid biology for combinatorial engineering of endotoxin
    Patent number: 8945587
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different species of lipid A on their surface. In one embodiment, the present disclosure provides for an engineered strain of E. coli according to Table 1. In another embodiment, the present disclosure provides for a lipopolysaccharide purified from an engineered strain of E. coli according to Table 1.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 3, 2015
    Assignee: The Board of Regents of The University of Texas System
    Inventors: M. Stephen Trent, Brittany Needham, David Giles, Marvin Whiteley
  • SYNTHETIC LIPID BIOLOGY FOR COMBINATORIAL ENGINEERING OF ENDOTOXIN
    Publication number: 20130230555
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different species of lipid A on their surface. In one embodiment, the present disclosure provides for an engineered strain of E. coli according to Table 1. In another embodiment, the present disclosure provides for a lipopolysaccharide purified from an engineered strain of E. coli according to Table 1.
    Type: Application
    Filed: February 28, 2013
    Publication date: September 5, 2013
    Applicant: Board of Regents, The University of Texas System
    Inventors: M. Stephen TRENT, Brittany Needham, David Giles, Marvin Whiteley
  • Quorum sensing signaling in bacteria
    Publication number: 20050227345
    Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.
    Type: Application
    Filed: December 15, 2004
    Publication date: October 13, 2005
    Applicants: Aurora Biosciences Corporation, UNIV OF IOWA RESEARCH FOUNDATION
    Inventors: Marvin Whiteley, Kimberly Lee, E. Greenberg, Ute Muh
  • Quorum sensing signaling in bacteria
    Patent number: 6855513
    Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: February 15, 2005
    Assignees: University of Iowa Research Foundation, Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Marvin Whiteley, Kimberly M. Lee, E. Peter Greenberg, Ute Muh
  • Methods and compositions for the modulation of biofilm formation
    Publication number: 20030113742
    Abstract: The present invention relates to methods for the modulation of biofilm formation and antibiotic resistance. Specifically, the present invention identifies the differential expression of biofilm-associated genes in biofilms, relative to their expression in non-biofilm producing bacterial cells. The present invention also identifies the differential expression of biofilm-associated genes in biofilms treated with antibiotic, relative to their expression in untreated biofilms. The present invention describes methods for the diagnostic evaluation of biofilm formation. The invention also provides methods for identifying a compound capable of modulating biofilm formation and antibiotic resistance. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of biofilm-associated diseases or disorders.
    Type: Application
    Filed: April 19, 2002
    Publication date: June 19, 2003
    Applicant: University of Iowa Research Foundation
    Inventors: Marvin Whiteley, M. Gita Bangera, Stephen Lory, Everett Peter Greenberg