Abstract: A mesh implant is disclosed and comprises a single sheet, highly porous, adhesion-resistant, tensile surgical implant composed of a gradually biodegradable synthetic polymer material that is electrospun into nanofibers and randomly stacked to form a three-dimensional (3D) mesh. The mesh implant is for tissue repair and hernia repair. The single-sheet design reduces the foreign material that make up the mesh implant, which minimizes mesh implant rejection. The gradually biodegradable nature of the mesh implant guarantees that the mesh stays in place and supports the repaired site long enough until a proper scar tissue has built up, after which the mesh implant disappears from the body, therefore preventing pain and irritability. The 3D design of the nanofibrous network and the high porosity of the mesh implant facilitate cell attachment, infiltration, and proliferation, all necessary for scar tissue formation, mesh integration, wound healing, and proper defect closure.

Abstract: As disclosed herein, the invention relates to a method of screening for a therapeutic for chronic myeloid leukemia. In an aspect, the invention relates to transgenic Drosophila. In an aspect, the invention relates to a Drosophila system for screening compounds treating chronic myeloid leukemia.

Abstract: There is provided a method and use of hematopoietic stem cells for the treatment of various diseases. The differentiation of autologueous hematopoietic stem cells into myeloid lineages is used for reintroduction into a patient in addition to undifferentiated stem cells for the purpose of reconstituting both the defence and long-term engraftment.

Abstract: There is provided co-culture bioreactor systems that can maintain stem cells and differentiated cell types in physically isolated environments but can allow biochemical communication between these cells. For instance, a co-culture bioreactor system of the present invention can include a first culture chamber that defines a first inlet and a first outlet such that fluid can flow through the culture chamber. The system can also include a second culture chamber defining a second inlet and a second outlet allowing a second fluid flow through this second chamber. The system can also include a semi-permeable membrane. The semi-permeable membrane can be located between the first culture chamber and the second culture chamber.