Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: This invention relates to a panty hose garment worn by a dancer or entertainer who is also wearing a revealing costume such as a G-string. This invention avoids the problem of having to roll down the top edge of the panty hose garment to be hidden underneath the dancer's or entertainer's costume. When the dancer or entertainer puts on the panty hose garment, according to this invention, it is stretched to a point such that the edges of the panty hose garment ride on the dancer's or entertainer's hips. The front slopes down in a V-shaped configuration following the contours of the G-string costume such that the edge is completely concealed by the G-string. The panty hose garment further includes a teardrop shaped crotch panel, such that the edges of the crotch panel do not extend over the edges of the G-string costume.