Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Abstract: Apparatuses including spark gap structures for electrical overstress (EOS) monitoring or protection, and associated methods, are disclosed. In an aspect, a vertical spark gap device includes a substrate having a horizontal main surface and a plurality of pairs of conductive layers over the horizontal main surface. Different ones of the pairs are separated by different vertical distances such that each pair serves as an arcing electrode pair and different ones of the arcing electrode pairs are configured to arc discharge at different voltages.

Abstract: The present invention is directed to methods of producing algal biomass and algal cell cultures, and lipid compounds and compositions thereof, including fatty acids, carotenoids and fat soluble vitamins. The present invention is further directed to methods of preparing related food products and industrial and pharmaceutical compositions. In various exemplary embodiments, the methods comprise growing algae in a juice based medium, including a medium that contains natural nitrogen or a medium that is free of chemical additives and preservatives, to produce algal cell cultures, algal biomass, algae derived lipid compounds and compositions, and related products, all that can be certified organic.

Abstract: An armrest for a motorcycle passenger, which permits one or both armrests to swing out to a side thereby accommodating a boarding passenger. Optionally, the armrests can be pivoted to rearward-facing orientation in order to form a rack behind a sissy bar of a motorcycle.

Abstract: An armrest for a motorcycle passenger, which permits one or both armrests to swing out to a side thereby accommodating a boarding passenger. Optionally, the armrests can be pivoted to rearward-facing orientation in order to form a rack behind a sissy bar of a motorcycle.

Abstract: The present invention is directed to methods comprising administering a composition comprising a therapeutically effective amount of (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats, prevents and/or manages at least one condition having MT1 receptor, 5-HT2B receptor and L-type calcium channel activity and releases the (R)-verapamil, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a co-primary activity on the MT1 receptor, the 5-HT2B receptor, and the L-type calcium channel.

Abstract: The present invention is directed to compositions and to methods comprising a composition comprising a therapeutically effective amount of a pharmaceutically active agent such as (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats and/or manages at least one condition having MT1 receptor activity and releases the pharmaceutically active agent, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a primary activity on the MT1 receptor such as, exhibiting at least five times more activity on the MT1 receptor compared with the MT2 receptor.

Abstract: Compounds according to formula (I) wherein Z is S, SO, or SO2, may be prepared by a process that includes charging to a reactor hydrogen sulfide and an alkyl glycidyl ether according to formula (III), in the presence of a base. The compounds may also be prepared by contacting an alkoxychlorohydrin according to formula (II) with a sulfide source.

Abstract: An arm rest assembly for a motorcycle passenger seat includes a vertically adjustable mount secured to the typical backrest behind the passenger seat. A U-shaped tubular member includes a medial portion rotatably secured in the mount, and arm rest cushions secured to opposed side arm portions. The U-shaped member is rotatable through an arc of approximately 180° about the axis of the medial portion, the range being limited by stop members joined to the medial portion. The side arm portions extend rearwardly to support baggage, or rotated to an upwardly extending disposition in which the passenger may mount or dismount the passenger seat, to a forwardly extending disposition in which the side arm portions extend to support the arms of the passenger and to provide side support for the passenger.

Abstract: The present invention is directed to methods comprising administering a composition comprising a therapeutically effective amount of (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats, prevents and/or manages at least one condition having MT1 receptor, 5-HT2B receptor and L-type calcium channel activity and releases the (R)-verapamil, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a co-primary activity on the MT1 receptor, the 5-HT2B receptor, and the L-type calcium channel.

Abstract: Compounds according to formula (I) wherein Z is S, SO, or SO2, may be prepared by a process that includes charging to a reactor hydrogen sulfide and an alkyl glycidyl ether according to formula (III), in the presence of a base.

Abstract: A method for identifying a gene having a role in the presentation of diabetic nephropathy comprises culturing mesangial cells in the presence of a concentration of glucose sufficient to induce differential expression, especially up-regulation, of a gene susceptible to such differential expression and identifying the gene so induced. The cells are also optionally subjected to mechanical strain and/or TGF-?1 can be added to the culture medium. The differentially expressed genes can be identified by suppression subtractive hybridisation. The method has resulted in the Identification of novel genes which play a role in the presentation of diabetic nephropathy. The genes can be used as diagnostic markers for diabetic nephropathy and as the basis of drug development programmes.

Abstract: This invention concerns an aluminum alloy container and lid for transportation and handling of perishable products. It combines the ability to provide improved temperature control for the product, and in addition is reusable, nestable and recyclable. This container is comprised of two components, the box and the lid. The box is made from three separate pieces. The bottom and two sides are formed from the same piece of material. The two ends are formed separately and each are welded to the bottom and two sides. The lid is made from two separate pieces, the lid plate and the interface bracket. All parts are made of light aluminum alloy.

Abstract: This invention concerns an aluminum alloy container and lid for transportation and handling of perishable products. It combines the ability to provide improved temperature control for the product, and in addition is reusable, nestable and recyclable. This container is comprised of two components, the box and the lid. The box is made from three separate pieces. The bottom and two sides are formed from the same piece of material. The two ends are formed separately and each are welded to the bottom and two sides. The lid is made from two separate pieces, the lid plate and the interface bracket. All parts are made of light aluminum alloy.

Abstract: A garment (20) for controlling excessive hand activity comprises a body clothing means (22) and a pair of sleeve members (24, 26) which each comprise a control end (28, 30). The control ends (28, 30) each comprise a plurality of envelopes (46, 48, 50, 52, 54). The plurality of envelopes are disposed in substantially concentric relation to each other and each contain an opening thereto. Each of the openings are disposed in substantial alignment with the other and are positioned, configured and dimensioned to receive a portion of a person's arm, wrist and hand.

Abstract: This invention relates to a device to be used by patients who when confined to bed are required to use bedpans and in particular a device having an inflatable portion that is so located in relation to the patients body as to exert a lifting force adjacent the base of the patient's spine so as to raise the lower body portion of the patient's torso and thus to allow with or without some cooperation of the patient the insertion of a bedpan under the patient in a proper position for use by the patient. The device is characterized as being constructed to be placed on the body of the patient and be worn so to speak, by the patient throughout the day or night, or both, in a deflated state and be maintained at all times of possible need, in place and in a state of readiness to be inflated with air or gas from a source under pressure such as a tank, individual can or a pump so as to lift the patient's body as required without resorting to manual lifting.