Abstract: Incretin analogs are provided that have activity at each of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors. The incretin analogs have structural features resulting in balanced activity and extended duration of action at each of these receptors. Methods also are provided for treating diseases such as type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and obesity.

Abstract: The present disclosure relates to the field of medicine. More particularly, the disclosure is in the field of treatment of diabetes, obesity and/or chronic weight management, dyslipidemia and/or NASH. The disclosure relates to compounds that agonize the amylin receptor and can lower food intake, body weight, glucose and/or triglycerides, so can be used to treat diabetes, obesity, and/or dyslipidemia. The present disclosure also includes pharmaceutical compositions containing such compounds and therapeutic uses of such compounds and compositions.

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: Dielectric in situ heating of materials using a resonant, non-radiating transformer. The target material is strategically formed into a part of the capacitance of the resonant system. The system may be used to heat in situ materials such as oilsands.

Abstract: Embodiments of the present invention overcome the problems in the existing art described above by providing a secure digital content licensing system and method. Rental of the digital content occurs within an online environment including one or more user network-enabled devices and one or more server network devices connected by a communications link to the one or more user network-enabled devices. A user selects content displayed on a main website and requests download of the selected content to the user network-enabled device. To be able to access the content the user must obtain a license. The user's request for a license for specific content comprises information about a desired rental model, an expiration date for the rental model, and information that identifies the user's user network-enabled device, along with other information. A license for the content is generated which comprises the above information and also includes an encryption key for the selected movie.

Abstract: Network systems and processes for delivery of electronic content to recipient processors may be configured to facilitate the delivery of relatively large content items and/or a relatively large number of content items. In one example, a movie rental system and process delivers (downloads) movie files to customers across the Internet. System network architecture includes three or more layers of servers, including a main server supporting an interface for recipient processors to request content items, a plurality of parent servers, and a plurality of edge servers. Edge servers are distributed throughout a region in which the system provides content delivery services to recipient processors. Parent servers, spaced across the service region, support edge servers. A copy of each content item available through the service is distributed from the main server to each parent servers for storage.

Abstract: Embodiments of the present invention overcome the problems in the existing art described above by providing a secure digital content licensing system and method. Rental of the digital content occurs within an online environment including one or more user network-enabled devices and one or more server network devices connected by a communications link to the one or more user network-enabled devices. A user selects content displayed on a main website and requests download of the selected content to the user network-enabled device. To be able to access the content the user must obtain a license. The user's request for a license for specific content comprises information about a desired rental model, an expiration date for the rental model, and information that identifies the user's user network-enabled device, along with other information. A license for the content is generated which comprises the above information and also includes an encryption key for the selected movie.