Abstract: Provided herein are methods for approximating transcription factor (TF) activity in a cell. The methods can approximate changes in TF activity resulting from a stimulus, such as a drug or cell differentiation. Some methods for approximating TF activity in a cell are laboratory methods. Some methods may be used to identify diagnostic signatures of transcription factor activity, and identify cell type or disease state. Computer-based systems for evaluating the effect of a stimulus on TF activity in a cell are also provided.

Abstract: A method for teaching a person, such as a child, to read aloud is disclosed. The method is implemented as a voice activated, visual software application that provides a visual display of a story as the person reads the words of the story. The method provides pronunciation assistance to the person, which in the software includes a simulated “teacher” that helps the person with assistance in reading the story. The method progresses through a sequence of story passages which together represent the entire story. The method progresses to each story passage upon successful completion of the current story passage by the person reading the story, such that the method will not allow the visual story to progress for the reader if a word is not read correctly out loud.

Abstract: Provided herein are methods for approximating transcription factor (TF) activity in a cell. The methods can approximate changes in TF activity resulting from a stimulus, such as a drug or cell differentiation. Some methods for approximating TF activity in a cell are laboratory methods. Some methods may be used to identify diagnostic signatures of transcription factor activity, and identify cell type or disease state. Computer-based systems for evaluating the effect of a stimulus on TF activity in a cell are also provided.

Abstract: A method for teaching a person, such as a child, to read aloud is disclosed. The method is implemented as a voice activated, visual software application that provides a visual display of a story as the person reads the words of the story. The method provides pronunciation assistance to the person, which in the software includes a simulated “teacher” that helps the person with assistance in reading the story. The method progresses through a sequence of story passages which together represent the entire story. The method progresses to each story passage upon successful completion of the current story passage by the person reading the story, such that the method will not allow the visual story to progress for the reader if a word is not read correctly out loud.

Abstract: This invention relates to an automated process for performing two or more consecutive reactions in a reaction vessel, said reaction vessel comprising an outlet at the base of said reaction vessel, and said process comprising: i) performing a first reaction is said reaction vessel, said first reaction comprising reacting one or more first reactants in the presence of a first catalyst, ii) uploading the reaction vessel of material therein through the outlet at the base of said reaction vessel and into a collecting vessel, iii) weighing the collecting vessel with the material therein, iv) calculating the mass of material collected, v) comparing the expected mass of material from the reaction to the value from step (iv), and vi) if the values correlate, subsequently performing a second reaction in said reaction vessel, said second reaction comprising reacting one or more second reactants in the presence of a second catalyst.

Abstract: The invention is generally related to the field of drug delivery systems comprising micelles. These systems may be used to deliver a photosensitizer as a pharmaceutical, agricultural, or industrial agent. The photosensitizer-containing formulations and compositions of the invention comprise one or more PEG-containing phospholipids. Furthermore, the invention relates to processes for the production of, and application of, said formulations and compositions as a drug delivery system.

Abstract: A hand puncture protector (10) including a pivoting shell which covers susceptible areas on the back and sides of the wearer's thumb (53), index finger (52) and thenar web space to reduce the risk of injury or infection from accidental punctures from needles and other sharp instruments ("SHARPS"). The pivoting shell is formed of a SHARP impervious material, such as thermoplastic, and has separate thumb (11) and index finger (12) components which are preferably fastened together by a single rivet (30) placed above the thenar web space region. VELCRO straps (20, 21) are affixed to the thumb and index finger regions of the molded shell at about the interphalange joint of the thumb and middle phalanx of the index finger to secure the hand protector to the user's hand. A method of protecting health care professionals from injury or infection by accidental punctures is also disclosed.