Patents by Inventor Mary Angelica Oba MAGSOMBOL-KARAAN

Mary Angelica Oba MAGSOMBOL-KARAAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOPICAL FORMULATIONS OF 5-ALPHA-REDUCTASE INHIBITORS AND USES THEREOF
    Publication number: 20230021330
    Abstract: Disclosed herein are topical compositions of 5-? reductase inhibitors, such as dutasteride or finasteride, or a pharmaceutically acceptable salt, ester, or derivative thereof and the use of the compositions for the treatment of hair loss secondary to endocrine therapy in patients with breast cancer (Endocrine Therapy-Induced Alopecia or ETIA), androgenetic alopecia (AGA), alopecia areata, and hirsutism. The topical composition is advantageous over the existing oral compositions of 5-? reductase inhibitors because the topical composition is safer and more effective. The topical formulation may allow for a slow release of the active ingredient dutasteride, better penetration at the therapeutically effective amount of dutasteride with an improved safety profile because it does not need to travel through the bloodstream to be efficacious, thereby minimizing the risk of systemic side effects.
    Type: Application
    Filed: March 31, 2022
    Publication date: January 26, 2023
    Inventors: Vinay K. JINDAL, Manu GUJRATI, Mary Angelica Oba MAGSOMBOL-KARAAN
  • Topical dutasteride emulsions for treating endocrine therapy-induced alopecia
    Patent number: 11311556
    Abstract: The invention features topical dutasteride emulsions for local delivery to the dermis of a subject suffering from hair loss, such as hair loss secondary to endocrine therapy in patients with breast cancer.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: April 26, 2022
    Assignee: Varsona Therapeutics, Inc.
    Inventors: Vinay Kumar Jindal, Manu Gujrati, Mary Angelica Oba Magsombol-Karaan
  • Topical formulations of 5-?-reductase inhibitors and uses thereof
    Patent number: 11311529
    Abstract: Disclosed herein are topical compositions of 5-? reductase inhibitors, such as dutasteride or finasteride, or a pharmaceutically acceptable salt, ester, or derivative thereof and the use of the compositions for the treatment of hair loss secondary to endocrine therapy in patients with breast cancer (Endocrine Therapy-Induced Alopecia or ETIA), androgenetic alopecia (AGA), alopecia areata, and hirsutism. The topical composition is advantageous over the existing oral compositions of 5-? reductase inhibitors because the topical composition is safer and more effective. The topical formulation may allow for a slow release of the active ingredient dutasteride, better penetration at the therapeutically effective amount of dutasteride with an improved safety profile because it does not need to travel through the bloodstream to be efficacious, thereby minimizing the risk of systemic side effects.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: April 26, 2022
    Assignee: Varsona Therapeutics, Inc.
    Inventors: Vinay K. Jindal, Manu Gujrati, Mary Angelica Oba Magsombol-Karaan
  • TOPICAL DUTASTERIDE EMULSIONS FOR TREATING ENDOCRINE THERAPY-INDUCED ALOPECIA
    Publication number: 20210353643
    Abstract: The invention features topical dutasteride emulsions for local delivery to the dermis of a subject suffering from hair loss, such as hair loss secondary to endocrine therapy in patients with breast cancer.
    Type: Application
    Filed: June 2, 2020
    Publication date: November 18, 2021
    Inventors: Vinay Kumar JINDAL, Manu GUJRATI, Mary Angelica Oba MAGSOMBOL-KARAAN