Patents by Inventor Mary Ann DeMaria

Mary Ann DeMaria has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for labeling intracytoplasmic molecules
    Patent number: 5648220
    Abstract: The invention features a method of labeling a cell containing an intracytoplasmic target molecule involving (1) permeabilizing the plasma membrane of the cell so that (a) a reagent capable of detectably labeling the intracytoplasmic target molecule can traverse the plasma membrane into the cytoplasm of the cell; and (b) substantially all of the intracytoplasmic target molecule and the DNA of the cell remain in the cell; and (2) contacting the cell with the reagent to label the intracytoplasmic target molecule. The method may further involve detecting the label in the cell, and isolating the cell on the basis of detecting the label in the cell. The invention also includes cells permeabilized using the method of the invention.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: July 15, 1997
    Assignee: New England Medical Center Hospitals, Inc.
    Inventors: Diana W. Bianchi, Mary Ann DeMaria