Patents by Inventor Mary-Ann Siegert

Mary-Ann Siegert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of (2S,3R,4R)-4,5-dihydroxyisoleucine and derivatives
    Patent number: 11584708
    Abstract: The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: February 21, 2023
    Assignee: Heidelberg Pharma Research GmbH
    Inventors: Caroline Knittel, Mary-Ann Siegert, Roderich Süssmuth, Christoph Wink, Gerhard Jas
  • SYNTHESIS OF AMANIN AND ITS DERIVATIVES
    Publication number: 20230039142
    Abstract: The present invention relates to the chemical synthesis of amanin and its derivatives. The present invention also relates to intermediate products of the amanin synthesis.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 9, 2023
    Applicant: HEIDELBERG PHARMA RESEARCH GMBH
    Inventors: Mary-Ann SIEGERT, Caroline KNITTEL, Roderich SÜSSMUTH
  • SYNTHESIS OF A-AMANITIN AND ITS DERIVATIVES
    Publication number: 20220298204
    Abstract: The present invention relates to the chemical synthesis of ?-amanitin and its derivatives. The present invention also relates to intermediate products of the ?-amanitin synthesis.
    Type: Application
    Filed: July 3, 2020
    Publication date: September 22, 2022
    Applicant: PURE BIOORGANICS SIA
    Inventors: Mary-Ann SIEGERT, Caroline Herta KNITTEL, Roderich SÜSSMUTH
  • Synthesis of (2S,3R,4R)-4,5-Dihydroxyisoleucine and Derivatives
    Publication number: 20210009507
    Abstract: The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 14, 2021
    Applicants: Heidelberg Pharma Research GmbH, Corden Pharma International GmbH
    Inventors: Caroline Knittel, Mary-Ann Siegert, Roderich Süssmuth, Christoph Wink, Gerhard Jas