Patents by Inventor Mary C. Betlach

Mary C. Betlach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant oleandolide polyketide synthase
    Publication number: 20030027287
    Abstract: Recombinant DNA compounds that encode all or a portion of the oleandolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of oleandolide, oleandolide derivatives, and polyketides that are useful as antibiotics and motilides.
    Type: Application
    Filed: March 14, 2001
    Publication date: February 6, 2003
    Inventors: Mary C. Betlach, Sanjay Krishnakant Shah, Robert McDaniel, Li Tang
  • Production of polyketides in plants
    Publication number: 20020002712
    Abstract: The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.
    Type: Application
    Filed: May 1, 2001
    Publication date: January 3, 2002
    Inventors: Mary C. Betlach, James T. Kealey, Neal Gutterson, Ed Ralston
  • Sorangium polyketide synthases and encoding DNA therefor
    Patent number: 6280999
    Abstract: Novel Sorangium polyketide synthases, and domains thereof, and polynucleotides encoding therefor. Additionally, chimeric polyketide synthases that include domains, or subsets of domains, patterned on said novel polyketide synthases. Methods to prepare polyketide combinatorial libraries are described, as are recombinant host cells in which polyketides are produced.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: August 28, 2001
    Assignee: Kosan Bioscience
    Inventors: Claes Gustafsson, Mary C. Betlach, Gary Ashley, Bryan Julien, Rainer Ziermann
  • Production of polyketides in plants
    Patent number: 6262340
    Abstract: The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: July 17, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Mary C. Betlach, James T. Kealey, Neal Gutterson, Ed Ralston
  • Recombinant oleandolide polyketide synthase
    Patent number: 6251636
    Abstract: Recombinant DNA compounds that encode all or a portion of the oleandolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of oleandolide, oleandolide derivatives, and polyketides that are useful as antibiotics and motilides.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: June 26, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Mary C. Betlach, Sanjay Krishnakant Shah, Robert McDaniel, Li Tang
  • Recombinant host cells for the production of polyketides
    Patent number: 6177262
    Abstract: Yields of polyketides produced in host cells such as Streptomyces can be increased by coexpression of the ptpA gene. The introduction of recombinant vectors encoding ptpA and polyketide synthase genes is more efficient and does not require methyl-free DNA if the host cell is a restriction/methylation deficient strain, such as Streptomyces lividans K4-114, K4-155, or K27-39.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: January 23, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Rainer Ziermann, Mary C. Betlach
  • Sorangium polyketide synthase
    Patent number: 6090601
    Abstract: Domains of epothilone polyketide synthase, and polynucleotides encoding therefor. Additionally, chimeric polyketide synthases that include domains, or subsets of domains, patterned on epothilone polyketide synthase. Methods to prepare epothilone in pharmaceutically useful quantitites are described, as are methods to prepare polyketide combinatorial libraries.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: July 18, 2000
    Assignee: Kosan Bioscience
    Inventors: Claes Gustafsson, Mary C. Betlach
  • Expression of heterologous polypeptides in halobacteria
    Patent number: 6010885
    Abstract: This invention relates to the preparation and use of expression systems capable of producing heterologous polypeptides in halobacterial hosts.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: January 4, 2000
    Assignee: The Regents of the University of California
    Inventors: George J. Turner, Mary C. Betlach
  • Expression of heterologous polypeptides in halobacteria
    Patent number: 5641650
    Abstract: This invention relates to the preparation and use of expression systems capable of producing heterologous polypeptides in halobacterial hosts.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: June 24, 1997
    Assignee: The Regents of the University of California
    Inventors: George J. Turner, Mary C. Betlach