Patents by Inventor Mary C. Farach-Carson

Mary C. Farach-Carson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Implantable modular hydrogel for salivary gland restoration
    Patent number: 9642941
    Abstract: Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 9, 2017
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Robert L. Witt, Xinqiao Jia, Swati Pradham Bhatt, Mary C. Farach-Carson, Daniel A. Harrington
  • Injectable delivery system for heparan-binding growth factors
    Patent number: 9597412
    Abstract: A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: March 21, 2017
    Assignee: University of Delaware
    Inventors: Catherine E. Safran, Mary C. Farach-Carson, Xinqiao Jia, Padma P. Srinivasan, Amit Jha
  • IMPLANTABLE MODULAR HYDROGEL FOR SALIVARY GLAND RESTORATION
    Publication number: 20140294960
    Abstract: Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 2, 2014
    Inventors: Robert L. Witt, Xinqiao Jia, Swati Pradham Bhatt, Mary C. Farach-Carson, Daniel A. Harrington
  • INJECTABLE DELIVERY SYSTEM FOR HEPARAN-BINDING GROWTH FACTORS
    Publication number: 20140005111
    Abstract: A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.
    Type: Application
    Filed: March 16, 2012
    Publication date: January 2, 2014
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: Catherine B. Safran, Mary C. Farach-Carson, Xinqiao Jia, Padma P. Srinivasa, Amit Jha
  • Perlecan fragments as biomarkers of bone stromal lysis
    Patent number: 8481273
    Abstract: A method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit for detecting the presence of these biomarkers in a body fluid, such as serum or urine, is also described.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: July 9, 2013
    Assignee: University of Delaware
    Inventor: Mary C. Farach-Carson
  • COMPOSITIONS AND METHODS FOR REPAIR OF TISSUES
    Publication number: 20110082081
    Abstract: Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and a growth factor, and, optionally, collagen.
    Type: Application
    Filed: October 12, 2010
    Publication date: April 7, 2011
    Applicant: University of Delaware
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Weidong (William) Yang
  • Bioactive peptide for cell adhesion
    Patent number: 7897727
    Abstract: Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: March 1, 2011
    Assignee: University of Delaware
    Inventors: Mary C. Farach-Carson, Daniel D. Carson, Jeffrey B. Safran
  • Delivery system for heparin-binding growth factors
    Patent number: 7875591
    Abstract: A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce replication and/or differentiation of connective tissue cells and to repair tissue.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: January 25, 2011
    Assignee: University of Delaware
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Margaret French, Ronald Gomes
  • Bioactive peptide for cell adhesion
    Patent number: 7803905
    Abstract: The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scaffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: September 28, 2010
    Assignee: University of Delaware
    Inventors: Mary C. Farach-Carson, Daniel D. Carson, Jeffrey B. Safran
  • Delivery System For Heparin-Binding Growth Factors
    Publication number: 20100221302
    Abstract: A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce replication and/or differentiation of connective tissue cells and to repair tissue.
    Type: Application
    Filed: April 22, 2009
    Publication date: September 2, 2010
    Applicant: UNIVERSITY OF DELAWARE
    Inventors: DANIEL D. CARSON, MARY C. FARACH-CARSON, MARGARET FRENCH, RONALD GOMES
  • Delivery system for heparin-binding growth factors
    Patent number: 7671018
    Abstract: New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and scaffolds coated with such proteoglycans are disclosed. The proteoglycan of the invention is derived from domain I or perlecan.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: March 2, 2010
    Assignee: University of Delaware
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Margaret French, Ronald Gomes, Rupert Timpl
  • Perlecan Fragments as Biomarkers of Bone Stromal Lysis
    Publication number: 20100021934
    Abstract: A method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit for detecting the presence of these biomarkers in a body fluid, such as serum or urine, is also described.
    Type: Application
    Filed: June 16, 2009
    Publication date: January 28, 2010
    Applicant: University of Delaware
    Inventor: Mary C. Farach-Carson
  • BIOACTIVE PEPTIDE FOR CELL ADHESION
    Publication number: 20090239304
    Abstract: Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.
    Type: Application
    Filed: March 5, 2009
    Publication date: September 24, 2009
    Applicant: University of Delaware
    Inventors: Mary C. Farach-Carson, Daniel D. Carson, Jeffrey B. Safran
  • Compositions and methods for repair of tissues
    Publication number: 20090162436
    Abstract: Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and a growth factor, and, optionally, collagen.
    Type: Application
    Filed: June 7, 2007
    Publication date: June 25, 2009
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Weidong (William) Yang
  • Treatment of osteoporosis and autoimmune disease with astrogorgiadiol
    Patent number: 7345035
    Abstract: The invention provides methods of downregulating mRNA encoding osteopontin comprising administering to a cell or mammal an amount of astrogorgiadiol effective to downregulate production of mRNA encoding osteopontin. The invention also provides methods of treating osteoporosis and autoimmune disease comprising administering to a patient in need of such treatment a therapeutically effective amount of astrogorgiadiol. Pharmaceutical compositions comprising astrogorgiadiol and a pharmaceutically acceptable carrier or diluent are also provided.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 18, 2008
    Assignee: University of Delaware
    Inventors: Douglass F. Taber, Mary C. Farach-Carson, Scott C. Malcolm, Yihuan Xu
  • Treatment of osteoporosis and autoimmune disease with astrogorgiadiol
    Publication number: 20040242677
    Abstract: The invention provides methods of downregulating mRNA encoding osteopontin comprising administering to a cell or mammal an amount of astrogorgiadiol effective to downregulate production of mRNA encoding osteopontin. The invention also provides methods of treating osteoporosis and autoimmune disease comprising administering to a patient in need of such treatment a therapeutically effective amount of astrogorgiadiol. Pharmaceutical compositions comprising astrogorgiadiol and a pharmaceutically acceptable carrier or diluent are also provided.
    Type: Application
    Filed: May 28, 2003
    Publication date: December 2, 2004
    Inventors: Douglass F. Taber, Mary C. Farach-Carson, Scott C. Malcolm, Yihuan Xu
  • Delivery system for heparin-binding growth factors
    Publication number: 20040063619
    Abstract: New uses of proteoglycans to bind and present growth factors, methods of accelerating wound, tissue or bone repair using such proteoglycans, pharmaceutical compositions of such proteoglycans, and scaffolds coated with such proteoglycans are disclosed. The proteoglycan of the invention is derived from domain I or perlecan.
    Type: Application
    Filed: August 4, 2003
    Publication date: April 1, 2004
    Inventors: Daniel D. Carson, Mary C. Farach-Carson, Margaret French, Ronald Gomes, Rupert Timpl
  • Bioactive peptide for cell adhesion
    Publication number: 20040043450
    Abstract: The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scalffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.
    Type: Application
    Filed: July 7, 2003
    Publication date: March 4, 2004
    Inventors: Mary C Farach-Carson, Daniel D Carson, Jeffrey B Safran