Patents by Inventor Mary Christine Zink

Mary Christine Zink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detection and quantitation of full-length thioredoxin (TRX) and truncated thioredoxin (TRX 80) in complex samples
    Patent number: 8512963
    Abstract: The present invention relates, e.g., to a method for detecting a full-length protein and a truncated form (e.g., a naturally occurring cleavage product) thereof, in a sample, comprising optionally denaturing and reducing proteins in the sample, cleaving the proteins into smaller peptides, and detecting a unique peptide identifier for the full-length protein and/or a unique peptide identifier for the truncated protein, in the sample. In one embodiment of the invention, the full-length protein is thioredoxin (TRX), and the truncated form thereof is its biologically active, C-terminal truncated, 10 kDa cleavage product, TRX 80.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: August 20, 2013
    Assignee: The Johns Hopkins University
    Inventors: David Raymond Graham, Susan Christine Trow, Mary Christine Zink
  • DETECTION AND QUANTITATION OF FULL-LENGTH THIOREDOXIN (TRX) AND TRUNCATED THIOREDOXIN (TRX 80) IN COMPLEX SAMPLES
    Publication number: 20110143379
    Abstract: The present invention relates, e.g., to a method for detecting a full-length protein and a truncated form (e.g., a naturally occurring cleavage product) thereof, in a sample, comprising optionally denaturing and reducing proteins in the sample, cleaving the proteins into smaller peptides, and detecting a unique peptide identifier for the full-length protein and/or a unique peptide identifier for the truncated protein, in the sample. In one embodiment of the invention, the full-length protein is thioredoxin (TRX), and the truncated form thereof is its biologically active, C-terminal truncated, 10 kDa cleavage product, TRX 80.
    Type: Application
    Filed: November 23, 2010
    Publication date: June 16, 2011
    Applicant: The Johns Hopkins University
    Inventors: David Raymond Graham, Susan Christine Trow, Mary Christine Zink