Abstract: Various implementations include peripherally inserted central catheters (PICCs) and methods for using PICCs. In a particular implementation, a PICC includes: a lumen having an innermost layer, at least one middle layer, an outermost layer, and a proximal end for inserting into a vessel, where the lumen is puncture resistant; a luer locking mechanism coupled to a distal end of the lumen, the luer locking mechanism having at least one injection port for mating with an external injectable medical device; and a housing unit at least partially surrounding the luer locking mechanism and preventing access to the at least one injection port.