Patents by Inventor Mary E. Abreu

Mary E. Abreu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5,6,7,8,9,10-hexahydro-7 ,10-iminocyclohept[b]indole,-6,7,8,9,10-hexahydro-7,11-imino-5H-cyclooct[ b]indole and substituted derivatives
    Patent number: 5250537
    Abstract: 5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited liability to produce concomitant adverse extrapyramidal symptoms. These compounds are also useful for treating other central nervous system and cardiovascular disorders.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: October 5, 1993
    Assignee: Scios Nova Inc.
    Inventors: Richard E. Mewshaw, Carl Kaiser, Mary E. Abreu
  • Corticotropin-releasing factor antagonism compounds
    Patent number: 5063245
    Abstract: The present invention relates to a method of producing corticotropin-releasing factor (CRF) antagonist activity and thus provides a method of treating a wide range of stress-related disorders, including affective illnesses, such as depression and anxiety, as well as irritable bowel syndrome, anorexia nervosa, cardiovascular abnormalities and stress-induced immune suppression. The invention also relates to compounds (4-substituted thio-5-oxo-3-pyrazolines) and to pharmaceutical compositions suitable for use in such a method.
    Type: Grant
    Filed: March 28, 1990
    Date of Patent: November 5, 1991
    Assignee: Nova Pharmaceutical Corporation
    Inventors: Mary E. Abreu, Waclaw Rzeszotarski, Donald J. Kyle, Roger N. Hiner, Richard L. Elliott