Patents by Inventor Mary E. Brawner

Mary E. Brawner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mouse CC-CKR5 receptor polypeptide
    Patent number: 6388055
    Abstract: Mouse CC-CKR5 polypeptides and DNA (RNA) encoding such mouse CC-CKR5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such mouse CC-CKR5 in the development of gene knockout mice for use as a model for human immunodeficiency virus.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: May 14, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Mary E. Brawner, Usman Shabon
  • Attachment enhanced 293 cells
    Patent number: 5863798
    Abstract: Attachment enhanced human embryonic kidney cells, 293, are provided. These cells have been modified to contain a selected mammalian scavenger gene, which has been found to improve the ability of these cells to attach in culture. The improved cells of the invention are useful in assays in which the unmodified 293 cells could be used.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: January 26, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul G. Lysko, Nabil A. Elshourbagy, Mary E. Brawner
  • Attachment enhanced 293 cells
    Patent number: 5683903
    Abstract: Attachment enhanced human embryonic kidney cells, 293, are provided. These cells have been modified to contain a selected mammalian scavenger gene, which has been found to improve the ability of these cells to attach in culture. The improved cells of the invention are useful in assays in which the unmodified 293 cells could be used.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: November 4, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul G. Lysko, Nabil A. Elshourbagy, Mary E. Brawner
  • Gal operon of streptomyces
    Patent number: 5435730
    Abstract: A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter; P2 promoter; P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: July 25, 1995
    Inventors: Craig W. Adams, Mary E. Brawner, James A. Fornwald, Francis J. Schmidt
  • Gal operon of streptomyces
    Patent number: 5242809
    Abstract: A recombinant DNA molecule comprising the Streptomyces gal operon galK gene; galE gene; galT gene; P1 promoter, P2 promoter, P2 promoter expression unit; P1 promoter regulated region; or the entire Streptomyces gal operon.
    Type: Grant
    Filed: October 27, 1992
    Date of Patent: September 7, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Craig W. Adams, Mary E. Brawner, James A. Fornwald, Francis J. Schmidt
  • Method of improving the yield of heterologous proteins produced by Streptomyces lividans
    Patent number: 5223418
    Abstract: A method is provided for improving the yield of the heterologous proteins sCD4 and derivatives of sCD4, produced by recombinant Streptomyces lividans by the addition of casamino acids to the nutrient medium in which the bacteria are cultured. Also provided by this invention is a method for improving the half-life of heterologous proteins in a cell free culture supernatant by the addition of casamino acids to the supernatant. Complex media are also provided.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: June 29, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Edward J. Arcuri, Mary E. Brawner, Mary J. Donovan, Robert G. Gerber, John A. Keller
  • Cloned streptomycete lividans excretable .beta.-galactosidase gene
    Patent number: 4717666
    Abstract: A DNA fragment from Streptomyces sp. which contains a gene which can code for an excretable protein is isolated, inserted into a plamid vector and used to transform other Streptomycetes.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: January 5, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Mary E. Brawner, Thomas G. Eckhardt, Louis R. Fare