Patents by Inventor Mary E. Dyszlewski

Mary E. Dyszlewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
    Publication number: 20020147316
    Abstract: The invention relates to novel aminocarboxylate ligands that are suitable for completing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes.
    Type: Application
    Filed: January 24, 2002
    Publication date: October 10, 2002
    Applicant: Mallinckrodt Inc.
    Inventors: David W. Pipes, Mary E. Dyszlewski, Elizabeth G. Webb
  • Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
    Patent number: 6359119
    Abstract: The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula fac-[M(CO)3(OH2)3]+  (I) wherein M is Mn, 99mTc, 186Re or 188Re, involves reacting a metal in permetallate form with carbon monoxide and stannous ion. The compound of formula (I) can be reacted with a ligand Lx to form a compound of the formula fac-[M(CO)3Lx]n  (II) wherein M is as defined above, Lx is a monodentate or multidentate ligand or a mixture of these ligands, and n is a charge of the ligand Lx increased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: March 19, 2002
    Assignee: Mallinckrodt Inc.
    Inventors: David W. Pipes, Mary E. Dyszlewski, Elizabeth G. Webb