Patents by Inventor Mary E. Vaman Rao

Mary E. Vaman Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF R-a-LIPOIC ACID BY FERMENTATION USING GENETICALLY ENGINEERED MICROORGANISMS
    Publication number: 20110262976
    Abstract: This application provides systems and methods for the production of R-?-lipoic acid. Lipoic acid synthesis genes may be expressed in an acid-tolerant microorganism, such as Gluconobacter oxydans. The lipoic acid synthesis proteins may include LipA and SufE. The genetically engineered strain may be cultured under suitable culture conditions, such as in a mannitol medium with an acidic pH.
    Type: Application
    Filed: January 16, 2009
    Publication date: October 27, 2011
    Applicant: Indigene Pharmaceuticals, Inc.
    Inventors: Mahesh Kandula, Mary E. Vaman Rao
  • COMPOSITIONS AND METHODS FOR TREATING NOS-ASSOCIATED DISEASES
    Publication number: 20110213021
    Abstract: The disclosures herein provide lipoic acid salts, as well as polymorphs, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, or injection. Such compositions may be used to treat NOS-associated diseases such as inflammatory diseases, metabolic diseases and neurodegenerative diseases.
    Type: Application
    Filed: March 3, 2009
    Publication date: September 1, 2011
    Applicant: Indigene Pharmaceuticals, Inc.
    Inventors: Mahesh Kandula, Mary E. Vaman Rao
  • Antidiabetic agent for control of diabetic hyperglycemia and diabetic complications
    Patent number: 7973073
    Abstract: Described herein is a compound of Formula I, which is the metformin salt of the naturally occurring endogenous biological compound, (R)-(+) ? lipoic acid, pharmaceutical compositions containing the compound of Formula I, and methods of treatment of diabetes or diabetic complications with the compound of Formula I.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: July 5, 2011
    Assignee: Indigene Pharmaceuticals, Inc.
    Inventors: Banavara L. Mylari, Mary E. Vaman Rao