Patents by Inventor Mary Ellen K. Salyan

Mary Ellen K. Salyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system
    Patent number: 6133239
    Abstract: An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: October 17, 2000
    Assignees: The Biomembrane Institute, Seikagaku Corporation
    Inventors: Kazuko Handa, Mary Ellen K. Salyan, Mark R. Stroud, Sen-itiroh Hakomori
  • Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof
    Patent number: 5876715
    Abstract: The invention relates to antibodies that specifically bind a myelorollin comprising an unbranched polylactosamine comprising at least 10 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except the penultimate N-acetylglucosamine residue. The invention also relates to a method of using such antibodies to inhibit E-selectin-dependent rolling of a cell on another cell, wherein one of the cells expresses a myelorollin that binds the antibodies.
    Type: Grant
    Filed: April 22, 1996
    Date of Patent: March 2, 1999
    Assignees: The Biomembrane Institute, Seikagaku Corporation
    Inventors: Kazuko Handa, Mary Ellen K. Salyan, Mark R. Stroud, Sen-itiroh Hakomori
  • Naturally occurring gangliosides containing de-N-acetyl-sialic acid and their applications as modifiers of cell physiology
    Patent number: 5272138
    Abstract: A method for preparing de-N-acylated forms of an N-acyl sugar-containing glycosphingolipid and lyso forms of glycosphingolipid comprising hydrolyzing the glycosphingolipids under mild alkaline conditions such that the N-acyl group of the sugar moiety is preferentially hydrolyzed. Substantially pure gangliosides containing de-N-acetyl-sialic acid isolated from natural sources. A culture medium for stimulating growth of human and animal cells comprising: essential nutrients for cell growth, and a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A method for stimulating growth of human and animal cells cultured in vitro with a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: December 21, 1993
    Assignee: The Biomembrane Institute
    Inventors: Sen-itiroh Hakomori, Gustavo A. Nores, Nobuo Hanai, Taeko Dohi, Steven B. Levery, Mary Ellen K. Salyan, Hisao Nojiri