Patents by Inventor Mary Ellen Warchal-Windham
Mary Ellen Warchal-Windham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11268925Abstract: Devices and methods for determining one or more analyte concentrations in a sample, determining a sample type, and/or accounting for interference species in a sample are disclosed that include intertwining a first input signal, via a first electrode having a reagent, with a second input signal, via a second electrode lacking a reagent, by applying to the sample the first input signal having at least two excitations and a relaxation, and applying to the sample the second input signal having at least two excitations and a relaxation, such that the excitations of the first input signal are nonconcurrent with the excitations of the second input signal. The method further includes measuring a first output signal responsive to the first input signal and a second output signal responsive to the second input signal.Type: GrantFiled: July 7, 2017Date of Patent: March 8, 2022Assignee: ASCENSIA DIABETES CARE HOLDINGS AGInventors: Huan-Ping Wu, Mary Ellen Warchal-Windham, Bern Everett Harrison, Nicole D. Ellis
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Patent number: 11180790Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: GrantFiled: May 13, 2020Date of Patent: November 23, 2021Assignee: Ascensia Diabetes Care Holdings AGInventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Publication number: 20200270668Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: ApplicationFiled: May 13, 2020Publication date: August 27, 2020Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Patent number: 10696998Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: GrantFiled: August 21, 2017Date of Patent: June 30, 2020Assignee: ASCENSIA DIABETES CARE HOLDINGS AGInventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Publication number: 20190293594Abstract: Devices and methods for determining one or more analyte concentrations in a sample, determining a sample type, and/or accounting for interference species in a sample are disclosed that include intertwining a first input signal, via a first electrode having a reagent, with a second input signal, via a second electrode lacking a reagent, by applying to the sample the first input signal having at least two excitations and a relaxation, and applying to the sample the second input signal having at least two excitations and a relaxation, such that the excitations of the first input signal are nonconcurrent with the excitations of the second input signal. The method further includes measuring a first output signal responsive to the first input signal and a second output signal responsive to the second input signal.Type: ApplicationFiled: July 7, 2017Publication date: September 26, 2019Inventors: Huan-Ping Wu, Mary Ellen Warchal-Windham, Bern Everett Harrison, Nicole D. Ellis
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Publication number: 20170349929Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: ApplicationFiled: August 21, 2017Publication date: December 7, 2017Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Patent number: 9664638Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: GrantFiled: December 3, 2015Date of Patent: May 30, 2017Assignee: Ascensia Diabetes Care Holdings AGInventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Publication number: 20160084790Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: ApplicationFiled: December 3, 2015Publication date: March 24, 2016Inventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Patent number: 9233788Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: GrantFiled: July 19, 2012Date of Patent: January 12, 2016Assignee: Bayer HealthCare LLCInventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Publication number: 20130186755Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: ApplicationFiled: July 19, 2012Publication date: July 25, 2013Applicant: BAYER HEALTHCARE LLC - DIABETES CAREInventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Patent number: 8184273Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence.Type: GrantFiled: January 10, 2011Date of Patent: May 22, 2012Assignee: Bayer Healthcare LLCInventors: Andrew J. Dosmann, Christine D. Nelson, Mary Ellen Warchal-Windham
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Publication number: 20110102768Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence.Type: ApplicationFiled: January 10, 2011Publication date: May 5, 2011Applicant: BAYER HEALTHCARE LLCInventors: Andrew J. Dosmann, Christine D. Nelson, Mary Ellen Warchal-Windham
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Patent number: 7867728Abstract: The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor, a tetrazolium salt indicator, but in the absence of a mediator.Type: GrantFiled: August 22, 2005Date of Patent: January 11, 2011Assignee: Bayer HealthCare LLCInventors: Karen L. Marfurt, Mary Ellen Warchal-Windham
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Patent number: 7869009Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence.Type: GrantFiled: July 12, 2010Date of Patent: January 11, 2011Assignee: Bayer Healthcare LLCInventors: Andrew J. Dosmann, Christine D. Nelson, Mary Ellen Warchal-Windham
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Publication number: 20100279326Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence.Type: ApplicationFiled: July 12, 2010Publication date: November 4, 2010Applicant: Bayer HealthCare LLCInventors: Andrew J. Dosmann, Christine D. Nelson, Mary Ellen Warchal-Windham
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Patent number: 7787109Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence.Type: GrantFiled: December 12, 2005Date of Patent: August 31, 2010Assignee: Bayer Healthcare LLCInventors: Andrew J. Dosmann, Christine D. Nelson, Mary Ellen Warchal-Windham
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Publication number: 20090145775Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: ApplicationFiled: December 10, 2008Publication date: June 11, 2009Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Publication number: 20080248581Abstract: A device and method for determining a correction factor for correcting the blood glucose assay bias based on sample hematocrit interference in a testing device using the blood hemoglobin concentration. The hemoglobin assay and the glucose assay may be performed using a single combination monitoring device.Type: ApplicationFiled: March 26, 2008Publication date: October 9, 2008Inventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Publication number: 20080198360Abstract: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be analyzed. The sample cell receiving area is constructed of a substantially optically clear material. The collimating lens is adapted to receive light from the light source and adapted to illuminate the sample cell receiving area with a substantially collimated beam of light. The first lens is adapted to receive regular and scattered light transmitted through the sample at a first angle of divergence. The first lens receives light having a first angle of acceptance. The first lens outputs light having a second angle of divergence. The second angle of divergence is less than the first angle of divergence.Type: ApplicationFiled: December 12, 2005Publication date: August 21, 2008Applicant: BAYER HEALTHCARE LLCInventors: Andrew J. Dosmann, Christine D. Nelson, Mary Ellen Warchal-Windham
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Patent number: 7163616Abstract: Reagents for detecting an analyte are described. A reagent comprises (a) an enzyme selected from the group consisting of a flavoprotein, a quinoprotein, and a combination thereof; and (b) a mediator selected from the group consisting of a phenothiazine, a phenoxazine, and a combination thereof. In addition, reagents having good stability to radiation sterilization are described. Electrochemical sensors and sampling devices comprising such reagents, methods of producing a sterilized device including such reagents, and methods for detecting an analyte which utilize such reagents are described as well.Type: GrantFiled: September 3, 2002Date of Patent: January 16, 2007Assignee: Bayer CorporationInventors: Mark S. Vreeke, Mary Ellen Warchal-Windham, Christina Blaschke, Barbara J. Mikel, Howard A. Cooper