Patents by Inventor Mary Ganley

Mary Ganley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled Release Microparticles
    Publication number: 20150037429
    Abstract: Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.
    Type: Application
    Filed: September 18, 2014
    Publication date: February 5, 2015
    Inventors: Kathleen M. Campbell, Pericles Calias, Gary P. Cook, Mary A. Ganley
  • Controlled release microparticles
    Patent number: 8877229
    Abstract: Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: November 4, 2014
    Assignee: Eyetech Inc.
    Inventors: Kathleen M. Campbell, Pericles Calias, Gary P. Cook, Mary A. Ganley
  • Controlled release microparticles
    Publication number: 20070292475
    Abstract: Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.
    Type: Application
    Filed: December 1, 2006
    Publication date: December 20, 2007
    Inventors: Kathleen Campbell, Pericles Calias, Gary Cook, Mary Ganley
  • Enhanced biologically active conjugates
    Publication number: 20050260651
    Abstract: The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.
    Type: Application
    Filed: April 13, 2005
    Publication date: November 24, 2005
    Inventors: Pericles Calias, Gary Cook, David Shima, Anthony Adamis, Yin-Shan Ng, Gregory Robinson, David Turner, Mary Ganley
  • Facilitation of iontophoresis using charged moieties
    Publication number: 20050260153
    Abstract: The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.
    Type: Application
    Filed: April 13, 2005
    Publication date: November 24, 2005
    Inventors: Pericles Calias, Gary Cook, David Shima, David Turner, Mary Ganley