Patents by Inventor Mary J. Donovan

Mary J. Donovan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of improving the yield of heterologous proteins produced by Streptomyces lividans
    Patent number: 5223418
    Abstract: A method is provided for improving the yield of the heterologous proteins sCD4 and derivatives of sCD4, produced by recombinant Streptomyces lividans by the addition of casamino acids to the nutrient medium in which the bacteria are cultured. Also provided by this invention is a method for improving the half-life of heterologous proteins in a cell free culture supernatant by the addition of casamino acids to the supernatant. Complex media are also provided.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: June 29, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Edward J. Arcuri, Mary E. Brawner, Mary J. Donovan, Robert G. Gerber, John A. Keller