Abstract: Provided are devices and related methods for weight loss. A size-varying gastric balloon is deployed in the stomach and a malabsorption sleeve is deployed in the small intestine. In some embodiments, the malabsorption sleeve is connected directly to the balloon. In other embodiments, the malabsorption sleeve is detached from the balloon and both are tethered to a transabdominal gastric cannula via a nutrient injection tube and a fluid conduit, respectively. The fluid conduit serves as pathway to introduce and remove fluid to/from the balloon as desired, and to tether the balloon in the stomach during use. The injection tube serves to facilitate controlled nutrition supply through the transabdominal gastric cannula to the small intestine, and to tether the malabsorption sleeve in the small intestine during use. Methods of using and deploying the devices described herein for weight-loss are also provided.

Abstract: Provided are devices and related methods for weight loss. A size-varying gastric balloon having a passage connected to an elongated sleeve forms a continuous pathway extension so that swallowed food is not absorbed by the body, thereby promoting weight loss. The connection of the sleeve to the gastric balloon avoids the need to directly anchor the proximal sleeve, with the balloon providing that anchoring function. Also provided are gastric balloons having a shape-controllable funnel to provide desired weight loss parameters tailored to the need of an individual and specially configured double lumen sleeves to facilitate controlled nutrition supply to a patient. Methods of deploying any of the devices described herein for weight-loss are also provided.

Abstract: Provided are devices and related methods for weight loss. A size-varying gastric balloon having a passage connected to an elongated sleeve forms a continuous pathway extension so that swallowed food is not absorbed by the body, thereby promoting weight loss. The connection of the sleeve to the gastric balloon avoids the need to directly anchor the proximal sleeve, with the balloon providing that anchoring function. Also provided are gastric balloons having a shape-controllable funnel to provide desired weight loss parameters tailored to the need of an individual and specially configured double lumen sleeves to facilitate controlled nutrition supply to a patient. Methods of deploying any of the devices described herein for weight-loss are also provided.