Patents by Inventor Mary J. Savage

Mary J. Savage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies, kit and method for detecting amyloid beta oligomers
    Patent number: 9310383
    Abstract: This invention is a selective A? oligomer kit and immunoassay method capable of reliably and sensitively detecting A? oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-A? oligomer antibodies, as capture and detection antibodies, to detect and quantify A? oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: April 12, 2016
    Assignees: Acumen Pharmaceuticals, Inc., Merck Sharp & Dohme Corp.
    Inventors: William F. Goure, Renee C. Gaspar, Alexander McCampbell, Mary J. Savage, Paul J. Shughrue, Fubao Wang, Weirong Wang, Abigail L. Wolfe, Ningyan Zhang, Wei-Qin Zhao, Min Xu
  • Antibodies, kit and method for detecting amyloid beta oligomers
    Patent number: 9176151
    Abstract: This invention is a selective A? oligomer kit and immunoassay method capable of reliably and sensitively detecting A? oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-A? oligomer antibodies, as capture and detection antibodies, to detect and quantify A? oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: November 3, 2015
    Assignee: Acumen Pharmaceuticals, Inc.
    Inventors: William F. Goure, Renee C. Gaspar, Alexander McCampbell, Mary J. Savage, Paul J. Shughrue, Fubao Wang, Weirong Wang, Abigail L. Wolfe, Nigyan Zhang, Wei-Qin Zhao
  • ANTIBODIES, KIT AND METHOD FOR DETECTING AMYLOID BETA OLIGOMERS
    Publication number: 20150260731
    Abstract: This invention is a selective A? oligomer kit and immunoassay method capable of reliably and sensitively detecting A? oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-A? oligomer antibodies, as capture and detection antibodies, to detect and quantify A? oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
    Type: Application
    Filed: June 3, 2015
    Publication date: September 17, 2015
    Inventors: William F. Goure, Renee C. Gaspar, Alexander McCampbell, Mary J. Savage, Paul J. Shughrue, Fubao Wang, Weirong Wang, Abigail L. Wolfe, Nigyan Zhang, Wei-Qin Zhao
  • METHOD FOR DETECTION OF AMYLOIDS BETA OLIGOMERS IN A FLUID SAMPLE AND USES THEREOF
    Publication number: 20140120037
    Abstract: The invention herein is directed to a selective A? oligomer immunoassay capable of reliably and sensitively detecting A? oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-A? oligomer antibodies, 19.3 and 82E1, to detect and quantify A? oligomers in a cerebrospinal fluid (CSF) sample. The inventive assay can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease. The inventive assay can also be used as a target engagement assay that can measure bound A? oligomers as a surrogate end-point for the assessment of therapeutic efficacy and/or target engagement.
    Type: Application
    Filed: December 20, 2013
    Publication date: May 1, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Mary J. Savage, Paul J. Shughrue, Alexander McCampbell, Abigail L. Wolfe
  • VACCINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20110002949
    Abstract: The invention provides a method for the treatment of a patient having a more severe form of Alzheimer's disease (AD), where the severe form of AD is characterized by pathogenic deposits of amyloid beta peptide (A?), comprising the administration of an immunogenic fragment of A? capable of inducing an immune response in the form of antibodies to specific to the pathogenic deposits of A? and, in particular, to neurotoxic forms of A? including N-terminally truncated forms of A?. The invention further provides a method for selecting a suitable immunogenic fragment of A? for the treatment of a more severe form of AD.
    Type: Application
    Filed: July 2, 2009
    Publication date: January 6, 2011
    Inventors: Mary J. Savage, Gene G. Kinney, Xiaoping Liang, Michael Citron, Laura B. Rosen