Patents by Inventor Mary Jackson

Mary Jackson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11154977
    Abstract: A system, method, and apparatus may be provided for gripping a handheld instrument. A spherical body may be configured to support at least a portion of the handheld instrument. A working portion of the handheld instrument may be oriented below a body of the gripping device. A top opening may be provided at a top of the gripping device, wherein the top opening may be configured to receive a portion of the handheld instrument. A bottom opening at the bottom of the gripping device may be provided, wherein the bottom opening may be configured to receive a portion of the handheld instrument. A convex surface may receive a palmar surface of a user's fingers, thumb, and/or hand.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: October 26, 2021
    Inventor: Janet Mary Jackson-Coty
  • Publication number: 20210031355
    Abstract: A system, method, and apparatus may be provided for gripping a handheld instrument. A spherical body may be configured to support at least a portion of the handheld instrument. A working portion of the handheld instrument may be oriented below a body of the gripping device. A top opening may be provided at a top of the gripping device, wherein the top opening may be configured to receive a portion of the handheld instrument. A bottom opening at the bottom of the gripping device may be provided, wherein the bottom opening may be configured to receive a portion of the handheld instrument. A convex surface may receive a palmar surface of a user's fingers, thumb, and/or hand.
    Type: Application
    Filed: August 1, 2019
    Publication date: February 4, 2021
    Inventor: Janet Mary Jackson-Coty
  • Publication number: 20200331897
    Abstract: The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.
    Type: Application
    Filed: February 21, 2020
    Publication date: October 22, 2020
    Applicants: Creighton University, Colorado State University Research Foundation
    Inventors: Jeffrey North, Amitkumar Navinchandra Pandya, Mary Jackson, Wei Li, Mercedes Gonzalez-Juarrero
  • Patent number: 7527788
    Abstract: Antibodies that bind to the M. tuberculosis Des protein are provided.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: May 5, 2009
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Patent number: 7264815
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: September 4, 2007
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20060241291
    Abstract: Antibodies that bind to the M. Tuberculosis des gene are provided.
    Type: Application
    Filed: February 21, 2006
    Publication date: October 26, 2006
    Inventors: Mary Jackson, Brigitte Gicquel
  • Patent number: 7071320
    Abstract: The use of genetic methodology based on the fusion of the proteins with the alcaline phosphatase (Lim et al., 1995) has allowed the isolation of a new exported protein of M. tuberculosis. In the present article, first of all the isolation of a gene encoding this exported protein called DES is described as well as its characterization and its distribution among the different mycrobacterial species. It is notably shown that the protein has in its primary sequence amino acids only found at the level of active sites of enzymes of class II diiron-oxo proteins family. Among the proteins of this family, DES protein of M. tuberculosis does not present significative homologies with stearoyl ACP desaturases. Secondly, the antigenic feature of this protein has been studied. For this, DES protein of M. tuberculosis has been overexpressed in E. coli under recombinant and purified protein form from this bacterium. The reactivity of tuberculous patients sera infected by M. tuberculosis or M.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: July 4, 2006
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Patent number: 7067136
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Grant
    Filed: August 10, 2004
    Date of Patent: June 27, 2006
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20060099221
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Application
    Filed: January 4, 2006
    Publication date: May 11, 2006
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20050244840
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Application
    Filed: August 10, 2004
    Publication date: November 3, 2005
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20050032107
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Application
    Filed: August 10, 2004
    Publication date: February 10, 2005
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20040142332
    Abstract: The use of genetic methodology based on the fusion of the proteins with the alcaline phosphatase (Lim et al., 1995) has allowed the isolation of a new exported protein of M. tuberculosis. In the present article, first of all the isolation of a gene encoding this exported protein called DES is described as well as its characterization and its destribution among the different microbacterial species. It is notably shown that the protein has in its primary sequence amino acids only found at the level of active sites of enzymes of class II diiron-oxo proteins family. Among the proteins of this family, DES protein of M. tuberculosis does not present significative homologies with stearoyl ACP desaturases. Secondly, the antigenic feature of this protein has been studied. For this, DES protein of M. tuberculosis has been overexpressed in E. coli under recombinant and purified protein from from this bacterium. The reactivity of tuberculous patients sera infected by M. tuberculosis or M.
    Type: Application
    Filed: February 20, 2003
    Publication date: July 22, 2004
    Applicant: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20030157589
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Application
    Filed: March 10, 2003
    Publication date: August 21, 2003
    Inventors: Mary Jackson, Brigitte Gicquel
  • Patent number: 6582925
    Abstract: The use of genetic methodology based on the fusion of the proteins with the alcaline phosphatase (Lim et al., 1995) has allowed the isolation of a new exported protein of M. tuberculosis. In the present article, first of all the isolation of a gene encoding this exported protein called DES is described as well as its characterization and its distribution among the different mycobacterial species. It is notably shown that the protein has in its primary sequence amino acids only found at the level of active sites of enzymes of class II diiron-oxo proteins family. Among the proteins of this family, DES protein of M. tuberculosis does not present significative homologies with stearoyl ACP desaturases. Secondly, the antigenic feature of this protein has been studied. For this, DES protein of M. tuberculosis has been overexpressed in E. coli under recombinant and purified protein form from this bacterium. The reactivity of tuberculous patients sera infected by M. tuberculosis or M.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: June 24, 2003
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Patent number: 6573064
    Abstract: This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic exchange experiments, indicate that the des gene may be essential to the survival of mycobacteria. These results coupled with the surface localization, the unique structure of DES, and the fact this antigen is expressed in vivo, and DES protein induces a humoral response in human patients, indicate that the DES protein provides a new target for the design of anti-mycobacterial drugs. This invention provides methods of screening molecules that can inhibit the DES enzyme activity of purified DES protein, in order to identify antibiotic molecules that are capable of inhibiting the growth or survival of mycobacteria.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: June 3, 2003
    Inventors: Mary Jackson, Brigitte Gicquel
  • Patent number: 6551808
    Abstract: The present invention relates to the isolation of a new gene, des, which encodes a M. tuberculosis protein named DES. The des gene appears to be conserved among different Mycobacteria species. The amino acid sequence of the DES protein contains two sets of motifs that are characteristic of the active sites of enzymes from the class II diiron-oxo protein family. Among this family of proteins, DES shares significant homology with soluble stearoyl-ACP desaturases. DES is a highly antigenic protein, which is recognized by human sera from patients infected with M. tuberculosis and M. leprae but not by sera from tuberculous cattle. Thus, the DES protein provides a useful tool for the serodiagnostic analysis of tuberculosis.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: April 22, 2003
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20020192781
    Abstract: The present invention relates to the isolation of a new gene, des, which encodes a M. tuberculosis protein named DES. The des gene appears to be conserved among different Mycobacteria species. The amino acid sequence of the DES protein contains two sets of motifs that are characteristic of the active sites of enzymes from the class II diiron-oxo protein family. Among this family of proteins, DES shares significant homology with soluble stearoyl-ACP desaturases. DES is a highly antigenic protein, which is recognized by human sera from patients infected with M. tuberculosis and M. leprae but not by sera from tuberculous cattle. Thus, the DES protein provides a useful tool for the serodiagnostic analysis of tuberculosis.
    Type: Application
    Filed: December 7, 2000
    Publication date: December 19, 2002
    Applicant: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel
  • Publication number: 20010024653
    Abstract: This invention provides recombinant mycobacterium strains of pathogenic origin that have been attenuated by the inactivation of a gene coding for a metabolic protein, specifically a gene coding for a protein necessary for the biosynthesis of a purine or a pyrimidine base, and more precisely, the purC gene that codes for an enzyme of the metabolic pathway of purine biosynthesis. The recombinant mycobacterium of this invention have a reduced capacity to propagate in a mammalian host, but remain viable in the host for a period of time sufficient to induce an protective immune response against the natural pathogenic mycobacterium counterpart.
    Type: Application
    Filed: May 9, 2001
    Publication date: September 27, 2001
    Applicant: Institut Pasteur
    Inventors: Bridgitte Gicquel, Christophe Guilhot, Mary Jackson
  • Patent number: 6261568
    Abstract: This invention provides recombinant mycobacterium strains of pathogenic origin that have been attenuated by the inactivation of a gene coding for a metabolic protein, specifically a gene coding for a protein necessary for the biosynthesis of a purine or a pyrimidine base, and more precisely, the purC gene that codes for an enzyme of the metabolic pathway of purine biosynthesis. The recombinant mycobacterium of this invention have a reduced capacity to propagate in a mammalian host, but remain viable in the host for a period of time sufficient to induce an protective immune response against the natural pathogenic mycobacterium counterpart.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: July 17, 2001
    Assignee: Institut Pasteur
    Inventors: Bridgitte Gicquel, Christophe Guilhot, Mary Jackson
  • Patent number: 6204038
    Abstract: The present invention relates to the isolation of a new gene, des, which encodes a M. tuberculosis protein named DES. The des gene appears to be conserved among different Mycobacteria species. The amino acid sequence of the DES protein contains two sets of motifs that are characteristic of the active sites of enzymes from the class II diiron-oxo protein family. Among this family of proteins, DES shares significant homology with soluble stearoyl-ACP desaturases. DES is a highly antigenic protein, which is recognized by human sera from patients infected with M. tuberculosis and M. leprae but not by sera from tuberculous cattle. Thus, the DES protein provides a useful tool for the serodiagnostic analysis of tuberculosis.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: March 20, 2001
    Assignee: Institut Pasteur
    Inventors: Mary Jackson, Brigitte Gicquel