Patents by Inventor Mary Jean Sparks

Mary Jean Sparks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO
    Publication number: 20120272341
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.
    Type: Application
    Filed: May 16, 2012
    Publication date: October 25, 2012
    Inventors: Katherin E. Combs, Ling Ling Culbertson, Juan Delmas-Mata, Frederic de Sauvage, Liangfen Fan, Gretchen Frantz, Leslie Jane Green, Erin Marie Massey, Dina Rebecca McLain, Charles Montgomery, Bobby Joe Payne, Franklin Peale, Heidi Phillips, Michelle Rohrer, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Ching-Yun Wang, Wen Xiong, Peter Vogel
  • Novel gene disruptions, compositions and methods relating thereto
    Publication number: 20120210450
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes.
    Type: Application
    Filed: April 8, 2011
    Publication date: August 16, 2012
    Inventors: Fred de Sauvage, Dorothy French, Lino Gonzalez, Asja Praetor, Weilan Ye, Katherin E. Combs, Zhiyong Ding, Allison Anne Byers Horner, Erin Marie Massey, Charles Montgomery, Laurie Jeanette Minze, Carolina Rangel, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Peter Vogel
  • Methods of identifying agents that ameliorate or modulate effects of PRO1328 gene disruptions
    Patent number: 8227661
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: July 24, 2012
    Assignee: Lexicon Genetics, Inc.
    Inventors: Joel A. Edwards, Wenhu Huang, Charles Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Oox
  • Novel PRO1199 gene disruptions, and methods relating thereto
    Publication number: 20120174239
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: October 27, 2011
    Publication date: July 5, 2012
    Inventors: Stephen Jay Anderson, Jane Brennan, Frederic J. de Sauvage, Zhiyong Ding, Joel Edwards, Nelda A. Fikes, Wenhu Huang, Wenjun Ouyang, Carolina Rangel, Mamta Sangha, Zheng-Zheng Shi, Mary Jean Sparks, Joseph Trackey, Melissa Vetter, Ching-Yun Wang, Jessica Woodings
  • Gene disruptions, compositions and methods relating thereto
    Patent number: 8207396
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: June 26, 2012
    Assignee: Genentech, Inc.
    Inventors: Bobby Joe Payne, Mary Jean Sparks, Wen Xiong
  • NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO
    Publication number: 20120030776
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes.
    Type: Application
    Filed: October 22, 2010
    Publication date: February 2, 2012
    Inventors: Katherin E. Combs, Ling Ling Culbertson, Frederic de Sauvage, Zhiyong Ding, Joel Edwards, Rosemary Girgis, Allison Anne Byers Horner, Harald Junge, Jagath Reddy Junutula, Erin Marie Massey, Dina Rebecca McLain, Charles Montgomery, Bobby Joe Payne, Heidi Phillips, Ni Nancy Qian, Carolina Rangel, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Peter Vogel, Weilan Ye
  • Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide
    Publication number: 20120005766
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes.
    Type: Application
    Filed: August 9, 2011
    Publication date: January 5, 2012
    Inventors: Kristi Rae Bollinger, Katherin E. Combs, Jaime-Jo Cunningham, Ling Ling Culbertson, Frederic J. de Sauvage, Joel Edwards, Leslie Jane Green, Rosemary Girgis, Allison Anne Byers Horner, Dina Rebecca McLain, Charles Montgomery, Laurie Jeanette Minze, Bobby Joe Payne, Heidi Phillips, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Teresa Gail Townsend, Peter Vogel
  • Novel gene disruptions, compositions and methods relating thereto
    Publication number: 20110252485
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO844, PRO1131 or PRO5992 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: June 13, 2011
    Publication date: October 13, 2011
    Inventors: Frederic de Sauvage, Ellen Filvaroff, Jagath Reddy Junutula, Bobby Joe Payne, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel
  • Novel Gene Disruptions, Compositions and Methods Relating Thereto
    Publication number: 20110191865
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: June 3, 2009
    Publication date: August 4, 2011
    Applicants: Genentech, Inc., Lexicon Genetics Incorporated
    Inventors: Joel A. Edwards, Wenhu Huang, Charles A. Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Westbrook
  • NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO
    Publication number: 20110182883
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes.
    Type: Application
    Filed: March 3, 2011
    Publication date: July 28, 2011
    Inventors: Katherin E. Combs, Frederic de Sauvage, Liangfen Fan, Ellen Filvaroff, Allison Anne Byers Horner, Bryan Irving, Jagath Reddy Junutula, Erin Marie Massey, Dina Rebecca Mclain, Laurie Jeanette Minze, Charles Montgomery, Bobby Joe Payne, Heidi Phillips, Carolina Rangel, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Teresa Gail Townsend, Peter Vogel
  • NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO
    Publication number: 20110173708
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.
    Type: Application
    Filed: February 18, 2011
    Publication date: July 14, 2011
    Inventors: Katherin E. Combs, Ling Ling Culbertson, Juan Delmas-Mata, Frederic de Sauvage, Liangfen Fan, Gretchen Frantz, Leslie Jane Green, Erin Marie Massey, Dina Rebecca McLain, Charles Montgomery, Bobby Joe Payne, Franklin Peale, Heidi Phillips, Michelle Rohrer, Tracy Ellen Willis Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Tracy Tzu-Ling Tang, Ching-Yun Wang, Wen Xiong, Peter Vogel
  • Gene disruptions, compositions and methods relating thereto
    Patent number: 7956237
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: June 7, 2011
    Assignee: Genentech, Inc.
    Inventors: Charles Montgomery, Zheng-Zheng Shi, Mary Jean Sparks
  • Gene disruptions, compositions and methods relating thereto
    Patent number: 7947866
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: May 24, 2011
    Assignee: Genentech, Inc.
    Inventor: Mary Jean Sparks
  • Novel Gene Disruptions, Compostitions and Methods Relating Thereto
    Publication number: 20110097330
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes.
    Type: Application
    Filed: February 27, 2006
    Publication date: April 28, 2011
    Applicants: Genentech, Inc., Lexicon Pharmaceuticals, Inc.
    Inventors: Allison Anne Byers Horner, Catherine Batac Clarke, Katherin E. Combs, Frederic J. de Sauvage, Joel Edwards, Paul Godowski, Deanna Grant Wilson, Wenhu Huang, Lorelei Diane Ketcherside, Erin Marie Massey, Charles Montgomery, Bobby Joe Payne, Andrew Peterson, Ni Nancy Qian, Jeffrey J. Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Colleen M. Viator, Peter Vogel, Weilan Ye, Jung-Hua Yeh, Zhiyong Ding
  • Gene disruptions, compositions and methods relating thereto
    Patent number: 7931902
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: April 26, 2011
    Assignee: Genentech, Inc.
    Inventors: Frederic J. de Sauvage, Gretchen Frantz, Charles Montgomery, Franklin Peale, Zheng-Zheng Shi, Mary Jean Sparks
  • Methods of identifying agents that ameliorate or modulate effects of PRO1328 gene disruptions
    Publication number: 20110093960
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: October 19, 2010
    Publication date: April 21, 2011
    Inventors: Joel A. Edwards, Wenhu Huang, Charles Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Oox
  • NOVEL PRO258 GENE DISRUPTIONS, AND METHODS RELATING THERETO
    Publication number: 20110061114
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Inventors: JOEL A. EDWARDS, Charles Montgomery, Zheng-Zheng Shi, Mary Jean Sparks
  • Gene disruptions, compositions and methods relating thereto
    Patent number: 7858843
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: December 28, 2010
    Assignee: Genentech, Inc.
    Inventors: Ling Ling Culbertson, Frederic J. de Sauvage, Charles Montgomery, Zheng-Zheng Shi, Mary Jean Sparks
  • Novel gene disruptions, compositions and methods relating thereto
    Publication number: 20100031378
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: August 4, 2008
    Publication date: February 4, 2010
    Inventors: Joel A. Edwards, Wenhu Huang, Charles Montgomery, Ni Nancy Qian, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel, Mindy Oox
  • Novel Gene Disruptions, Compositions and Methods Relating Thereto
    Publication number: 20090313707
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes.
    Type: Application
    Filed: May 18, 2006
    Publication date: December 17, 2009
    Applicants: Genentech, Inc., Lexicon Pharamaceuticals, Inc.
    Inventors: Katherin E. Combs, Ling Ling Culbertson, Frederic J. de Sauvage, Zhiyong Ding, Joel Edwards, Rosemary Girgis, Allison A. B. Horner, Harald Junge, Jagath Reddy Junutula, Erin Marie Massey, Dina R. McLain, Charles Montgomery, Bobby Joe Payne, Heidi Phillips, Ni Nancy Qian, Carolina Rangel, Tracy E. W. Sevaux, Zheng-Zheng Shi, Mary Jean Sparks, Joy Anne Stala, Peter Vogel, Weilan Ye