Patents by Inventor Mary Jo Donovan

Mary Jo Donovan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective reduction of substituted acetophenone
    Patent number: 6800477
    Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: October 5, 2004
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ramesh Patel, Animesh Goswami, Linda N. Chu, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Mary Jo Donovan, K. David Mirfakhrae
  • Stereoselective reduction of substituted acetophenone
    Publication number: 20030068811
    Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.
    Type: Application
    Filed: March 6, 2002
    Publication date: April 10, 2003
    Inventors: Ramesh Patel, Animesh Goswami, Linda N. Chu, Venkata B. Nanduri, Steven L. Goldberg, Robert M. Johnston, Mary Jo Donovan, K. David Mirfakhrae
  • Stereoselective reductive amination of ketones
    Patent number: 6468781
    Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 22, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Hanson, Mary Jo Donovan, Steven Goldberg, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, Laszlo J. Szarka, John J. Venit
  • Stereoselective reductive amination of ketones
    Patent number: 6140088
    Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: October 31, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Hanson, Mary Jo Donovan, Steven Goldberg, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, Laszlo J. Szarka, John J. Venit