Patents by Inventor Mary Jo Rosovitz

Mary Jo Rosovitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant modified protective antigen for use in vaccines
    Patent number: 8394387
    Abstract: The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: March 12, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Stephen H. Leppla, Mary Jo Rosovitz, John B. Robbins, Rachel Schneerson, S. Dana Hsu, Joseph Shiloach, Delia M. Ramirez
  • RECOMBINANT MODIFIED BACILLUS ANTHRACIS PROTECTIVE ANTIGEN FOR USE IN VACCINES
    Publication number: 20130058967
    Abstract: The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
    Type: Application
    Filed: July 31, 2007
    Publication date: March 7, 2013
    Inventors: Stephen H. Leppla, Mary Jo Rosovitz, John B. Robbins, Rachel Schneerson, S. Dana Hsu, Joseph Shiloach, Delia M. Ramirez
  • Methods for preparing protective antigen for use in vaccines
    Patent number: 7763451
    Abstract: The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: July 27, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph Shiloach, Stephen H. Leppla, Delia M. Ramirez, Rachel Schneerson, John B. Robbins, S. Dana Hsu, Mary Jo Rosovitz
  • Recombinant modified protective antigen for use in vaccines
    Patent number: 7261900
    Abstract: The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: August 28, 2007
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Stephen H. Leppla, Mary Jo Rosovitz, John B. Robbins, Rachel Schneerson
  • Methods for preparing Bacillus anthracis sporulation deficient mutants and for producing recombinant Bacillus anthracis protective antigen for use in vaccines
    Publication number: 20040171121
    Abstract: The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
    Type: Application
    Filed: August 8, 2003
    Publication date: September 2, 2004
    Inventors: Stephen H. Leppla, Mary Jo Rosovitz, S. Dana Hsu