Patents by Inventor Mary K. BALACONIS

Mary K. BALACONIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-analyte sensing tissue-integrating sensors
    Patent number: 11903702
    Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: February 20, 2024
    Assignee: Profusa, Inc.
    Inventors: Mary K. Balaconis, Scott Nichols, Sierra Guidry, Yu Zhang, Ryan Schweller, Soya Gamsey, Jacob William Clary, Sulolit Pradhan, Natalie Wisniewski
  • Oxidase-based sensors and methods of using
    Patent number: 11534503
    Abstract: Oxidase-based sensors and methods of using the sensors are provided.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: December 27, 2022
    Assignee: Profusa, Inc.
    Inventors: Mary K. Balaconis, Scott Nichols
  • MULTI-ANALYTE SENSING TISSUE-INTEGRATING SENSORS
    Publication number: 20210128035
    Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.
    Type: Application
    Filed: September 14, 2020
    Publication date: May 6, 2021
    Applicant: Profusa, Inc.
    Inventors: Mary K. BALACONIS, Scott NICHOLS, Sierra GUIDRY, Yu ZHANG, Ryan SCHWELLER, Soya GAMSEY, Jacob William CLARY, Sulolit PRADHAN, Natalie WISNIEWSKI
  • Multi-analyte sensing tissue-integrating sensors
    Patent number: 10772546
    Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: September 15, 2020
    Assignee: Profusa, Inc.
    Inventors: Mary K. Balaconis, Scott Nichols, Sierra Guidry, Yu Zhang, Ryan Schweller, Soya Gamsey, Jacob William Clary, Sulolit Pradhan, Natalie Wisniewski
  • OXIDASE-BASED SENSORS AND METHODS OF USING
    Publication number: 20200023079
    Abstract: Oxidase-based sensors and methods of using the sensors are provided.
    Type: Application
    Filed: December 28, 2018
    Publication date: January 23, 2020
    Inventors: Mary K. BALACONIS, Scott NICHOLS
  • Compositions and methods for measurement of analytes
    Patent number: 10197498
    Abstract: Disclosed herein sensor matrices comprising nanofibers and one or more sensor components, wherein the one or more sensor components detect an analyte. In addition, methods of making and detecting the sensor matrices are disclosed. For example, a nanofiber with a shell and coaxial core may be made with a sensor in the shell.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: February 5, 2019
    Assignee: Northeastern University
    Inventors: Timothy T. Ruckh, Mary K. Balaconis, Heather A. Clark, Christopher Skipwith
  • COMPOSITIONS AND METHODS FOR MEASUREMENT OF ANALYTES
    Publication number: 20160274030
    Abstract: Disclosed herein sensor matrices comprising nanofibers and one or more sensor components, wherein the one or more sensor components detect an analyte. In addition, methods of making and detecting the sensor matrices are disclosed. For example, a nanofiber with a shell and coaxial core may be made with a sensor in the shell.
    Type: Application
    Filed: October 21, 2014
    Publication date: September 22, 2016
    Applicant: Northeastern University
    Inventors: Timothy T. RUCKH, Mary K. BALACONIS, Heather A. CLARK, Christopher SKIPWITH