Patents by Inventor Mary K. Hondalus

Mary K. Hondalus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated vaccines
    Patent number: 7758874
    Abstract: Non-naturally occurring mycobacteria in the Mycobacterium tuberculosis complex are provided. These mycobacteria have a deletion of an RD1 region or a region controlling production of a vitamin, and exhibit attenuated virulence in a mammal when compared to the mycobacteria without the deletion. Also provided are non-naturally occurring mycobacteria that have a deletion of a region controlling production of lysine, and mycobacteria comprising two attenuating deletions. Vaccines comprising these mycobacteria are also provided, as are methods of protecting mammals from virulent mycobacteria using the vaccines. Also provided are methods of preparing these vaccines which include the step of deleting an RD1 region or a region controlling production of a vitamin or the amino acids leucine and lysine from a mycobacterium in the M. tuberculosis complex. Embodiments of these mycobacteria, vaccines and methods, encompassing mycobacteria comprising a leucine auxotrophy and a pantothenate auxotrophy, are also provided.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: July 20, 2010
    Assignees: Albert Einstein College of Medicine of Yeshiva University, President and Fellows of Harvard College
    Inventors: William R. Jacobs, Jr., Barry Bloom, Mary K. Hondalus, Samantha Sampson, Vasan Sambandamurthy
  • Recombinant M. tuberculosis auxotrophic for leucine and vaccines using same
    Patent number: 6562348
    Abstract: The present invention provides a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine. The present invention also provides a vaccine comprising a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine, as well as a method for treating or preventing tuberculosis in a subject comprising administering to the subject a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine in an amount effective to treat or prevent tuberculosis in the subject.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: May 13, 2003
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Mary K. Hondalus, Barry R. Bloom, William R. Jacobs, Jr.
  • RECOMBINATION M. TUBERCULOSIS MYCOBACTERIUM AUXOTROPHIC FOR LEUCINE AND VACCINES USING SAME
    Publication number: 20020068067
    Abstract: The present invention provides a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine. The present invention also provides a vaccine comprising a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine, as well as a method for treating or preventing tuberculosis in a subject comprising administering to the subject a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine in an amount effective to treat or prevent tuberculosis in the subject.
    Type: Application
    Filed: July 8, 1999
    Publication date: June 6, 2002
    Inventors: MARY K. HONDALUS, BARRY R. BLOOM, WILLIAM R. JACOBS