Patents by Inventor Mary Kay Pflum

Mary Kay Pflum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell permeable ATP analog for kinase-catalyzed biotinylation
    Patent number: 10429397
    Abstract: A cell permeable ATP analog has the following formula: or a physiologically acceptable salt thereof, wherein: R0 is n, o, p are each independently 1, 2, 3, 4, 5, or 6, m is 0, 1, 2, 3, 4, or 5; X is O, S, NH, or CH2. R1 is H or C1-6 alkyl, R2 is H, C1-6 alkyl, C6-30 aryl, C5-32 heteroaryl, or C7-32 alkylaryl; R3, R4 are each independently H, C1-6 alkyl, C6-30 aryl, C5-32 heteroaryl, or C7-32 alkylaryl, wherein R3, and R4 can be combined together to form a ring structure.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: October 1, 2019
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Mary Kay Pflum
  • Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity
    Patent number: 10259779
    Abstract: A compound having formula I for histone deacetylase inhibition is provided: or a pharmaceutically acceptable salt or hydrate thereof wherein R is alkyl, C6-18 aryl, C5-18 heteroaryl, C8-22 alkylaryl, C8-22 alkylheteroaryl, or halo.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: April 16, 2019
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Mary Kay Pflum
  • Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8 selectivity
    Publication number: 20180057448
    Abstract: A compound having formula I for histone deacetylase inhibition is provided: or a pharmaceutically acceptable salt or hydrate thereof wherein R is alkyl, C6-18 aryl, C5-18 heteroaryl, C8-22 alkylaryl, C8-22 alkylheteroaryl, or halo.
    Type: Application
    Filed: August 25, 2017
    Publication date: March 1, 2018
    Inventor: MARY KAY PFLUM
  • CELL PERMEABLE ATP ANALOG FOR KINASE-CATALYZED BIOTINYLATION
    Publication number: 20160377626
    Abstract: A cell permeable ATP analog has the following formula: or a physiologically acceptable salt thereof, wherein: R0 is n, o, p are each independently 1, 2, 3, 4, 5, or 6, m is 0, 1, 2, 3, 4, or 5; X is O, S, NH, or CH2. R1 is H or C1-6 alkyl, R2 is H, C1-6 alkyl, C6-30 aryl, C5-32 heteroaryl, or C7-32 alkylaryl; R3, R4 are each independently H, C1-6 alkyl, C6-30 aryl, C5-32 heteroaryl, or C7-32 alkylaryl, wherein R3, and R4 can be combined together to form a ring structure.
    Type: Application
    Filed: June 20, 2016
    Publication date: December 29, 2016
    Inventor: MARY KAY PFLUM
  • CROSS-LINKING ATP ANALOGS
    Publication number: 20120258481
    Abstract: An adenosine 5?-triphosphate analogs modified at the gamma-phosphate with a reactive reagent. A method of forming the analog by activating a 4-amino benzoic acid, incubating the activated acid to obtain an amine, and coupling the amine with ATP in the presence of water soluble EDCI. A method of detecting the efficacy of a therapeutic by adding a gamma-phosphate modified ATP analog to a protein substrate, reacting the target proteins with the ATP analog, and analyzing the resulting cross-linked product, wherein the amount of product present correlates to the efficacy of the therapeutic is also provided.
    Type: Application
    Filed: January 19, 2012
    Publication date: October 11, 2012
    Applicant: WAYNE STATE UNIVERSITY
    Inventor: Mary Kay Pflum