Patents by Inventor Mary L. Bouxsein

Mary L. Bouxsein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated cell comprising a nucleic acid encoding antibody inhibitors of gdf-8 and uses thereof
    Patent number: 9505831
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: November 29, 2016
    Assignee: Wyeth LLC
    Inventors: Jane Aghajanian, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • Antibody Inhibitors of GDF-8 and Uses Thereof
    Publication number: 20150024484
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Application
    Filed: April 18, 2014
    Publication date: January 22, 2015
    Applicant: Wyeth LLC
    Inventors: Jane Aghajanian, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity
    Patent number: 8710202
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: April 29, 2014
    Assignee: Wyeth LLC
    Inventors: Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein, William J. Dunham
  • Antibody Inhibitors of GDF-8 and Uses Thereof
    Publication number: 20120107928
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 3, 2012
    Applicant: Wyeth LLC
    Inventors: Jane Aghajanian, William J. Dunham, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8
    Patent number: 8092798
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: January 10, 2012
    Assignee: Wyeth LLC
    Inventors: Jane Aghajanian, William J. Dunham, legal representative, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • ActRIIB FUSION POLYPEPTIDES AND USES THEREFOR
    Publication number: 20110250198
    Abstract: Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis.
    Type: Application
    Filed: December 10, 2010
    Publication date: October 13, 2011
    Applicant: Wyeth LLC
    Inventors: Neil M. Wolfman, Mary L. Bouxsein
  • ANTIBODY INHIBITORS OF GDF-8 AND USES THEREOF
    Publication number: 20110020330
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Application
    Filed: May 24, 2010
    Publication date: January 27, 2011
    Applicant: Wyeth
    Inventors: Jane Aghajanian, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein, William J. Dunham
  • Methods of increasing muscle mass or muscle strength using antibody inhibitors of GDF-8
    Patent number: 7731961
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: June 8, 2010
    Assignee: Wyeth
    Inventors: Jane Aghajanian, William J. Dunham, legal representative, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • ActRIIB Fusion Polypeptides and Uses Therefor
    Publication number: 20090087375
    Abstract: Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis.
    Type: Application
    Filed: August 7, 2007
    Publication date: April 2, 2009
    Applicant: Wyeth
    Inventors: Neil M. Wolfman, Mary L. Bouxsein
  • ActRIIB Fusion Polypeptides and Uses Therefor
    Publication number: 20090087433
    Abstract: Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis.
    Type: Application
    Filed: August 7, 2007
    Publication date: April 2, 2009
    Applicant: Wyeth
    Inventors: Neil M. Wolfman, Mary L. Bouxsein
  • ActRIIB fusion polypeptides and uses therefor
    Publication number: 20040223966
    Abstract: Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis.
    Type: Application
    Filed: October 22, 2003
    Publication date: November 11, 2004
    Inventors: Neil M. Wolfman, Mary L. Bouxsein
  • Antibody inhibitors of GDF-8 and uses thereof
    Publication number: 20030138422
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Application
    Filed: September 25, 2002
    Publication date: July 24, 2003
    Inventors: Jane Aghajanian, William J. Dunham, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein