Patents by Inventor Mary L. Disis

Mary L. Disis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE
    Publication number: 20230357718
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Application
    Filed: July 13, 2023
    Publication date: November 9, 2023
    Applicants: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Peter A. Cohen, JR., Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • Methods and materials for expanding antigen-specific T cells in culture
    Patent number: 11739296
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 29, 2023
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • METHODS AND VACCINES FOR INDUCING IMMUNE RESPONSES TO MULTIPLE DIFFERENT MHC MOLECULES
    Publication number: 20230098624
    Abstract: This document provides methods and materials relating to isolated polypeptides, polypeptide preparations, vaccine preparations (e.g., anti-cancer vaccine preparations), and methods for vaccinating mammals. For example, polypeptides (e.g., CMV, MUC1, HER2, Mesothelin (MESO), TRAG-3, or CALR polypeptides) having the ability to be processed into different polypeptides such that the processed polypeptides as a group are capable of being presented by different MHC molecules present in a particular mammalian population are provided.
    Type: Application
    Filed: August 24, 2022
    Publication date: March 30, 2023
    Inventors: Dustin B. McCurry, Peter A. Cohen, Latha B. Pathangey, Sandra J. Gendler, Mary L. Disis
  • Methods and vaccines for inducing immune responses to multiple different MHC molecules
    Patent number: 11464839
    Abstract: This document provides methods and materials relating to isolated polypeptides, polypeptide preparations, vaccine preparations (e.g., anti-cancer vaccine preparations), and methods for vaccinating mammals. For example, polypeptides (e.g., CMV, MUC1, HER2, Mesothelin (MESO), TRAG-3, or CALR polypeptides) having the ability to be processed into different polypeptides such that the processed polypeptides as a group are capable of being presented by different MHC molecules present in a particular mammalian population are provided.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: October 11, 2022
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Dustin B. McCurry, Peter A. Cohen, Latha B. Pathangey, Sandra J. Gendler, Mary L. Disis
  • BREAST AND OVARIAN CANCER VACCINES
    Publication number: 20220040275
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Application
    Filed: October 20, 2021
    Publication date: February 10, 2022
    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Mary L. DISIS, Denise Cecil, Meredith Slota
  • Breast and ovarian cancer vaccines
    Patent number: 11185578
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: November 30, 2021
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Mary L. Disis, Denise Cecil, Meredith Slota
  • BREAST AND OVARIAN CANCER VACCINES
    Publication number: 20210346480
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Application
    Filed: June 25, 2021
    Publication date: November 11, 2021
    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Mary L. DISIS, Denise CECIL, Meredith SLOTA
  • Breast and ovarian cancer vaccines
    Patent number: 11160853
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: November 2, 2021
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATON
    Inventors: Mary L. Disis, Denise Cecil, Meredith Slota
  • Cancer vaccine compositions and methods of use thereof
    Patent number: 10759836
    Abstract: The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include nucleic acids. The present application also describes compositions that include peptides. Also described herein are methods that include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: September 1, 2020
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Mary L. Disis, Elizabeth Broussard
  • METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE
    Publication number: 20200248140
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Application
    Filed: April 14, 2020
    Publication date: August 6, 2020
    Inventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • Methods and materials for expanding antigen-specific T cells in culture
    Patent number: 10647961
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: May 12, 2020
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • BREAST AND OVARIAN CANCER VACCINES
    Publication number: 20200054725
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Application
    Filed: March 29, 2019
    Publication date: February 20, 2020
    Inventors: Mary L. Disis, Denise Cecil, Meredith Slota
  • HLA-DR binding peptides and their uses
    Patent number: 10556943
    Abstract: The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 11, 2020
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Keith L. Knutson, Mary L. Disis, John D. Fikes, Melanie Beebe, Glenn Ishioka
  • Breast and ovarian cancer vaccines
    Patent number: 10293035
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: May 21, 2019
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Mary L. Disis, Denise Cecil, Meredith Slota
  • METHODS AND VACCINES FOR INDUCING IMMUNE RESPONSES TO MULTIPLE DIFFERENT MHC MOLECULES
    Publication number: 20190000948
    Abstract: This document provides methods and materials relating to isolated polypeptides, polypeptide preparations, vaccine preparations (e.g., anti-cancer vaccine preparations), and methods for vaccinating mammals. For example, polypeptides (e.g., CMV, MUC1, HER2, Mesothelin (MESO), TRAG-3, or CALR polypeptides) having the ability to be processed into different polypeptides such that the processed polypeptides as a group are capable of being presented by different MHC molecules present in a particular mammalian population are provided.
    Type: Application
    Filed: December 2, 2016
    Publication date: January 3, 2019
    Inventors: Dustin B. McCurry, Peter A. Cohen, Latha B. Pathangey, Sandra J. Gendler, Mary L. Disis
  • METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE
    Publication number: 20180245042
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Application
    Filed: August 12, 2016
    Publication date: August 30, 2018
    Inventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • HLA-DR BINDING PEPTIDES AND THEIR USES
    Publication number: 20170342126
    Abstract: The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.
    Type: Application
    Filed: December 16, 2016
    Publication date: November 30, 2017
    Inventors: Keith L. Knutson, Mary L. Disis, John D. Fikes, Melanie Beebe, Glenn Ishioka
  • CANCER VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170283475
    Abstract: The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include nucleic acids. The present application also describes compositions that include peptides. Also described herein are methods that include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Application
    Filed: July 17, 2015
    Publication date: October 5, 2017
    Applicant: University of Washington
    Inventors: Mary L. DISIS, Elizabeth BROUSSARD
  • METHODS OF IDENTIFYING ANTIGENS FOR VACCINES
    Publication number: 20170266269
    Abstract: The methods, processes, and systems described herein include identifying an epitope of a peptide that may elicit an immune response in a subject. Often the methods, systems and processes may include designing and producing a composition comprising an epitope of a peptide identified using the methods or processes described herein.
    Type: Application
    Filed: March 27, 2015
    Publication date: September 21, 2017
    Inventors: Mary L. DISIS, Denise CECIL, Meredith SLOTA
  • BREAST AND OVARIAN CANCER VACCINES
    Publication number: 20170182137
    Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.
    Type: Application
    Filed: March 27, 2015
    Publication date: June 29, 2017
    Inventors: Mary L. DISIS, Denise CECIL, Meredith SLOTA