Patents by Inventor Mary Louise Morgan

Mary Louise Morgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modifying the permeability of physiological barriers
    Publication number: 20020142943
    Abstract: The degree of phosphorylation of serine and threonine residues of p100/p120 can affect the permeability of physiological barriers and also cell-cell adhesion properties. By changing physiological levels, various disorders can be treated, including multiple sclerosis, cancer, head injuries, oedema, stroke, inflammation and gastric ulcers. Furthermore, drugs can be allowed to pass across physiological barriers and the barriers can then be closed.
    Type: Application
    Filed: May 24, 2002
    Publication date: October 3, 2002
    Applicant: Eisai Co., Limited
    Inventors: James Martin Staddon, Mary Louise Morgan, Marianne Jennifer Ratcliffe
  • Modifying the permeability of physiological barriers
    Patent number: 6407058
    Abstract: The degree of phosphorylation of serine and threonine residues of p100/p120 can affect the permeability of physiological barriers and also cell—cell adhesion properties. By changing physiological levels, various disorders can be treated, including multiple sclerosis, cancer, head injuries, oedema, stroke, inflammation and gastric ulcers. Furthermore, drugs can be allowed to pass across physiological barriers and the barriers can then be closed.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: June 18, 2002
    Assignee: Eisai Co., Limited
    Inventors: James Martin Staddon, Mary Louise Morgan, Marianne Jennifer Ratcliffe
  • Modulating the permeability of a physiological barrier with an agent that modulates tyrosine phosphorylation
    Patent number: 6312686
    Abstract: Permeability of the blood-brain barrier and other physiological barriers can be modulated by the degree of tyrosine phosphorylation of proteins. Agents which promote tyrosine protein dephosphorylation reduce the permeability of the blood-brain barrier and those which promote phosphorylation increase permeability. Increasing blood-brain barrier permeability is useful in delivering drugs having a desired effect upon the central nervous system; decreasing blood-brain barrier permeability and other physiological barrier permeability is useful in preventing undesired compounds reaching the CNS and in certain clinical conditions.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: November 6, 2001
    Assignee: Eisai Co., Ltd.
    Inventors: James Martin Staddon, Lee Laurence Rubin, Kurt Herrenknecht, Mary Louise Morgan