Patents by Inventor Mary Lynn Trawick

Mary Lynn Trawick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS
    Publication number: 20190010173
    Abstract: This present disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin L, cathepsin K, and/or cathepsin B, will be therapeutically useful. Formula I: or a solvate or pharmaceutically acceptable salt thereof. Each of R1-R10 are independently selected from the group consisting of: hydrogen, alkoxy, halo, hydroxy, phosphate, phosphate salts, disodium phosphate, diphosphate dimer, diphosphate dimer salt, and sodium diphosphate dimer with at least one of R1-R10 is a phosphate or diphosphate dimer group.
    Type: Application
    Filed: August 12, 2016
    Publication date: January 10, 2019
    Applicants: Mateon Therapeutics, Inc., Baylor University
    Inventors: Kevin G. Pinney, Mary Lynn Trawick, Erica N. Parker, David J. Chaplin
  • Compositions and methods for inhibition of cathepsins
    Patent number: 9873668
    Abstract: This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: January 23, 2018
    Assignees: Mateon Therapeutics, Inc., Baylor University
    Inventors: David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick
  • COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS
    Publication number: 20160368869
    Abstract: This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.
    Type: Application
    Filed: August 31, 2016
    Publication date: December 22, 2016
    Inventors: David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick
  • Compositions and methods for inhibition of cathepsins
    Patent number: 8877967
    Abstract: This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: November 4, 2014
    Assignees: OXiGENE, Inc., Baylor University
    Inventors: David J. Chaplin, Kishore Kumar Gaddale Devanna, Erica Parker, Kevin G. Pinney, Jiangli Song, Mary Lynn Trawick
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 8173696
    Abstract: The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: May 8, 2012
    Assignee: Baylor University
    Inventors: Rogelio Siles, Ming Zhou, J. Freeland Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick
  • INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
    Publication number: 20090076076
    Abstract: The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
    Type: Application
    Filed: June 13, 2008
    Publication date: March 19, 2009
    Applicant: Baylor University
    Inventors: Rogelio Siles, Ming Zhou, J. Freeland Ackley, Kevin G. Pinney, Shen-En Chen, Wara Milenka Arispe-Angulo, Mary Lynn Trawick