Patents by Inventor Mary M. Rozenman

Mary M. Rozenman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reaction discovery system
    Patent number: 8691729
    Abstract: A novel reaction discovery system that does not depend on DNA duplex formation is provided. The advantages of this system include exploring reactions conditions not possible where DNA hybridization is required. For example, the inventive reaction discovery system allows for reaction conditions using organic solvents, higher temperatures, and water-insoluble reagents, catalysts, and ligands. The invention also provides single-stranded oligonucleotide templates with substrate pairs covalently attached and methods of screening for reaction conditions that result in a direct covalent bond between the substrates. Kits are also provided for practicing this novel reaction discovery system.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: April 8, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Matthew William Kanan, Mary M. Rozenman
  • REACTION DISCOVERY SYSTEM
    Publication number: 20110312507
    Abstract: A novel reaction discovery system that does not depend on DNA duplex formation is provided. The advantages of this system include exploring reactions conditions not possible where DNA hybridization is required. For example, the inventive reaction discovery system allows for reaction conditions using organic solvents, higher temperatures, and water-insoluble reagents, catalysts, and ligands. The invention also provides single-stranded oligonucleotide templates with substrate pairs covalently attached and methods of screening for reaction conditions that result in a direct covalent bond between the substrates. Kits are also provided for practicing this novel reaction discovery system.
    Type: Application
    Filed: January 9, 2008
    Publication date: December 22, 2011
    Applicant: President and Fellows of Harvard College
    Inventors: David R. Liu, Matthew William Kanan, Mary M. Rozenman
  • Palladium-catalyzed carbon-carbon bond forming reactions
    Patent number: 7851658
    Abstract: A novel palladium-mediated carbon-carbon bond forming reaction has been discovered using DNA-templated chemistry. The inventive reaction involves the palladium-mediated coupling of a terminal alkyne with an alkene to form an enone. A catalytic amount of palladium may be used in the reaction if an oxidant is present. The reactions is also compatible with a variety of organic solvent as well as aqueous solution. Both intermolecular and intramolecular reactions have been demonstrated. This novel carbon-carbon bond forming reaction is particularly useful in the synthesis of macrocycles. Kits, reagents, catalysts, solvents, oxidants, salts, acids, instructions, and other materials useful in the practice of the inventive reaction are also provided.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: December 14, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Matthew W. Kanan, Mary M. Rozenman
  • NUCLEIC ACID-TEMPLATED CHEMISTRY IN ORGANIC SOLVENTS
    Publication number: 20090035824
    Abstract: The present invention provides methods and compositions for performing nucleic acid mediated chemistry in a variety of organic solvents. A variety of nucleic acid mediated chemical reactions may be efficiently carried out in organic solvents.
    Type: Application
    Filed: June 16, 2006
    Publication date: February 5, 2009
    Inventors: David R. Liu, Mary M. Rozenman, Christopher T. Calderone