Patents by Inventor Mary Margaret Mader

Mary Margaret Mader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF EZH2
    Publication number: 20170066780
    Abstract: The present invention relates to compounds that inhibit activity of the histone lysine methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors.
    Type: Application
    Filed: August 22, 2016
    Publication date: March 9, 2017
    Inventors: Esteban DOMINGUEZ, Deqi GUO, Mary Margaret MADER, Anh-Quan Hannah NGUYEN, Miriam DEL PRADO, Michael Enrico RICHETT, Michael John RODRIGUEZ, Yvonne Yee Mai YIP, Kuo-Long YU
  • PI3 kinase/mTOR dual inhibitor
    Patent number: 8658668
    Abstract: The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: February 25, 2014
    Assignee: Eli Lilly and Company
    Inventors: David Anthony Barda, Mary Margaret Mader
  • PI3 KINASE/mTOR DUAL INHIBITOR
    Publication number: 20130237562
    Abstract: The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
    Type: Application
    Filed: April 16, 2013
    Publication date: September 12, 2013
    Applicant: Eli Lilly and Company
    Inventors: David Anthony Barda, Mary Margaret Mader
  • PI3 kinase/mTOR dual inhibitor
    Patent number: 8440829
    Abstract: The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: May 14, 2013
    Assignee: Eli Lilly and Company
    Inventors: David Anthony Barda, Mary Margaret Mader
  • PI3 KINASE/mTOR DUAL INHIBITOR
    Publication number: 20120184577
    Abstract: The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 19, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: David Anthony Barda, Mary Margaret Mader
  • Kinase inhibitors
    Patent number: 7652015
    Abstract: The present invention provides kinase inhibitors of Formula (I). Wherein R1, R2, X and Z are as described herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: January 26, 2010
    Assignee: Eli Lilly and Company
    Inventors: Jolie Anne Bastian, Jesus Andres Blas de Blas, Alfonso De Dios, Kevin John Hudziak, Tiechao Li, Beatriz López De Uralde-Garmendia, Mary Margaret Mader, Michael Ray Myers, Mark Andrew Pobanz, Chuan Shih, Boyu Zhong
  • KINASE INHIBITORS
    Publication number: 20090318443
    Abstract: The present invention provides kinase inhibitors of Formula I.
    Type: Application
    Filed: July 27, 2009
    Publication date: December 24, 2009
    Inventors: Rosanne Bonjouklian, Chafiq Hamdouchi Hamdouchi, Chuan Shih, Alfonso De Dios, Miriam Filadelfa Del Prado, Carlos Jaramillo Aguado, Pramila Kotiyan, Mary Margaret Mader, Sheila Pleite Selgas, Concepcion Sanchez-Martinez
  • Kinase inhibitors
    Patent number: 7582652
    Abstract: The present invention provides kinase inhibitors of Formula I.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: September 1, 2009
    Assignee: Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Chafiq Hamdouchi, Chuan Shih, Alfonso De Dios, Miriam Filadelfa del Prado, Carlos Jaramillo Aguado, Pramila Kotiyan, Mary Margaret Mader, Sheila Pleite Selgas, Concepcion Sanchez-Martinez
  • Pyrazole-isoquinoline urea derivatives as p38 kinase inhibitors
    Patent number: 7582638
    Abstract: The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: September 1, 2009
    Assignee: Eli Lilly and Company
    Inventors: Alfonso De Dios, Cristina Garcia-Paredes, Beatriz López de Uralde Garmendia, Mary Margaret Mader, Mark Andrew Pobanz, Chuan Shih, Boyu Zhong
  • ANTITUMOR BENZOYLSULFONAMIDES
    Publication number: 20090118323
    Abstract: The present invention provides antitumor compounds of the formula (I); and antitumor methods.
    Type: Application
    Filed: September 11, 2007
    Publication date: May 7, 2009
    Inventors: Mary Margaret Mader, Luisa Maria Martin-Cabrejas, Michael Enrico Richett
  • Mixed lineage kinase modulators
    Patent number: 7511065
    Abstract: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: March 31, 2009
    Assignee: Eli Lilly and Company
    Inventors: Theodore Goodson, Jr., Mary Margaret Mader, John Eldon Toth, Arindam Chatterjee, Jason Scott Sawyer
  • KINASE INHIBITORS
    Publication number: 20090036445
    Abstract: The present invention provides kinase inhibitors of Formula I.
    Type: Application
    Filed: January 25, 2005
    Publication date: February 5, 2009
    Inventors: Rosanne Bonjouklian, Chafiq Hamdouchi, Chuan Shih, Alfonso De Dios, Miriam Filadelfa del Prado, Carlos Jaramillo Aguado, Pramila Kotiyan, Mary Margaret Mader, Sheila Pleite Selgas, Concepcion Sanchez-Martinez
  • Pyrazole-Isoquinoline Urea Derivatives as P38 Kinase Inhibitors
    Publication number: 20080275056
    Abstract: The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 23, 2006
    Publication date: November 6, 2008
    Inventors: Alfonso De Dios, Cristina Garcia-Paredes, Beatriz Lopez Uralde Garmendia, Mary Margaret Mader, Mark Andrew Pobanz, Chuan Shih, Boyu Zhong
  • Kinase Inhibitors
    Publication number: 20080269244
    Abstract: The present invention provides kinase inhibitors of Formula (I). Wherein R1, R2, X and Z are as described herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 25, 2006
    Publication date: October 30, 2008
    Inventors: Jolie Anne Bastian, Jesus Andres Blas de Blas, Alfonso De Dios, Kevin John Hudziak, Tiechao Li, Beatriz Lopez De Uralde-Garmendia, Mary Margaret Mader, Michael Ray Myers, Mark Andrew Pobanz, Chuan Shih, Boyu Zhong
  • Mixed Lineage Kinase Modulators
    Publication number: 20080113977
    Abstract: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
    Type: Application
    Filed: November 12, 2003
    Publication date: May 15, 2008
    Inventors: Arindam Chatterjee, Theodore Goodson Jr, Mary Margaret Mader, John Eldon Toth
  • Antitumor benzoylsulfonamides
    Patent number: 7282595
    Abstract: The present invention provides antitumor compounds of the formula (I); and antitumor methods.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: October 16, 2007
    Assignee: Eli Lilly and Company
    Inventors: Mary Margaret Mader, Luisa Maria Martin-Cabrejas, Michael Enrico Richett
  • Thiophene-and thiazolesulfonamides as antineoplastic agents
    Patent number: 7250430
    Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: July 31, 2007
    Assignee: Eli Lilly and Company
    Inventors: Cora Sue Grossman, Philip Arthur Hipskind, Ho-Shen Lin, Karen Lynn Lobb, Beatriz Lopez de Uralde Garmendia, Jose Eduardo Lopez, Mary Margaret Mader, Michael Enrico Richett, Chuan Shih, Alfonso De Dios
  • Thiophene-amd thiazolesulfonamides as antineoplastic agents
    Patent number: 7084170
    Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: August 1, 2006
    Assignee: Eli Lilly and Company
    Inventors: Cora Sue Grossman, Philip Arthur Hipskind, Ho-Shen Lin, Karen Lynn Lobb, Beatriz Lopez de Uralde Garmendia, Jose Eduardo Lopez, Mary Margaret Mader, Michael Enrico Richett, Chuan Shih, Alfonso De Dios
  • Thiophene-amd thiazolesulfonamides as antineoplastic agents
    Publication number: 20040198784
    Abstract: The present invention provides antineoplastic compounds of the formula (D).
    Type: Application
    Filed: March 26, 2004
    Publication date: October 7, 2004
    Inventors: Cora Sue Grossman, Philip Arthur Hipskind, Ho-Shen Lin, Karen Lynn Lobb, Beatriz Lopez de Uralde Garmendia, Jose Eduardo Lopez, Mary Margaret Mader, Michael Enrico Richett, Chuan Shih, Alfonso de Dios