Patents by Inventor Mary N. Omstead

Mary N. Omstead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of farnesyl-protein transferase
    Patent number: 5510371
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: April 23, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Sheo B. Singh, George M. Garrity, Olga Genillourd, Russell B. Lingham, Isabel Martin, Mary N. Omstead, Keith C. Silverman, Deborah L. Zink
  • Process for forming cholesterol lowering compound using pseudodiplodia sp.
    Patent number: 5284758
    Abstract: This invention relates to a fungal microorganism Pseudodiplodia sp. (MF5767) isolated from bark discs of Hibiscus sp. and useful in a fermentation process to form compounds of formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: February 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Mary N. Omstead, Wendy H. Clapp, Fernando Pelaez
  • Directed biosynthesis of cholesterol lowering compounds
    Patent number: 5252471
    Abstract: Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthetase inhibitors useful as cholesterol-lowering agents.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: October 12, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Byrne, Louis Kaplan, Mary N. Omstead
  • Processes for preparing novel squalene synthetase inhibitors
    Patent number: 5250424
    Abstract: This invention relates to strains of the species Curvularia lunata isolated from tree bark and useful in a fermentation process to form compounds of formula (I): ##STR1##
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: October 5, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Maria T. Diez, Mary N. Omstead, Fernando Pelaez
  • Squalene synthetase inhibitors and processes therefrom
    Patent number: 5200342
    Abstract: This invention relates to strains of the species Curvularia lunata isolated from tree bark and useful in a fermentation process to form compounds of formula (I): ##STR1##
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: April 6, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Maria T. Diez, Mary N. Omstead, Fernando Pelaez
  • Process for producing FK-506
    Patent number: 5194378
    Abstract: Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp., (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: March 16, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gino M. Salituro, Francis Dumont, George M. Garrity, Leeyuan Huang, E. Tracy T. Jones, Mary N. Omstead, Isabel M. Fernandez, Teresa D. Matas
  • Process for the glycosylation of avermectin agylcones
    Patent number: 5188944
    Abstract: Avermectin aglycones are glycosylated by fermentation in a medium of a non-producing mutant of Streptomyces avermitilis MA-6078. The glycosylation produces the monosaccharide and disaccharide derivatives while leaving the remainder of the molecule intact. The microorganism glycosylates with the .alpha.-L-oleandrose moiety.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: February 23, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mary N. Omstead, Marvin D. Schulman, Noel M. Young