Patents by Inventor Mary N. Teruel

Mary N. Teruel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and apparatus for the high through-put detection of binding interactions in vivo
    Patent number: 6682927
    Abstract: An apparatus for screening for translocation of a first protein of interest in vivo in a plurality of cells comprises (a) a thin unitary total internal reflection member having a surface portion, (b) a plurality cell contacted to said surface portion by the plasma membrane of said cell, said cell containing said first protein of interest, the protein of interest having a fluorescent group conjugated thereto; (c) a light source operatively associated with the total internal reflection member and positioned for directing a source light into the member to produce an evanescent field adjacent the surface portion, with the evanescent field extending into a first portion of the cell adjacent the plasma membrane, the evanescent field being weaker in a second portion of the cell, the fluorescent group emitting light when in the first portion of the cell and emitting less light when in the second portion of the cell; (d) coupling means for coupling the light source to the thin unitary total internal reflection member
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: January 27, 2004
    Assignees: Duke University, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tobias Meyer, Mary N. Teruel
  • Methods and apparatus for the high through-put detection of binding interactions in VIVO
    Publication number: 20020076729
    Abstract: An apparatus for screening for translocation of a first protein of interest in vivo in a plurality of cells comprises (a) a thin unitary total internal reflection member having a surface portion, (b) a plurality cell contacted to said surface portion by the plasma membrane of said cell, said cell containing said first protein of interest, the protein of interest having a fluorescent group conjugated thereto; (c) a light source operatively associated with the total internal reflection member and positioned for directing a source light into the member to produce an evanescent field adjacent the surface portion, with the evanescent field extending into a first portion of the cell adjacent the plasma membrane, the evanescent field being weaker in a second portion of the cell, the fluorescent group emitting light when in the first portion of the cell and emitting less light when in the second portion of the cell; (d) coupling means for coupling the light source to the thin unitary total internal reflection member
    Type: Application
    Filed: April 5, 2001
    Publication date: June 20, 2002
    Inventors: Tobias Meyer, Mary N. Teruel