Patents by Inventor Mary P. Hall

Mary P. Hall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COELENTERAZINE ANALOGUES
    Publication number: 20240059697
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: May 19, 2023
    Publication date: February 22, 2024
    Inventors: Joel R. Walker, Thomas A. Kirkland, Wenhui Zhou, Mary P. Hall, Harry Tetsuo Uyeda
  • NANOLUC SUICIDE SUBSTRATES
    Publication number: 20230382908
    Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.
    Type: Application
    Filed: April 5, 2023
    Publication date: November 30, 2023
    Inventors: Brock Binkowski, Mary P. Hall, Thomas Machleidt, Joel Walker, Wenhui Zhou
  • Coelenterazine analogues
    Patent number: 11691976
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 4, 2023
    Assignee: Promega Corporation
    Inventors: Joel R. Walker, Thomas A. Kirkland, Wenhui Zhou, Mary P. Hall, Harry Tetsuo Uyeda
  • Nanoluc suicide substrates
    Patent number: 11655247
    Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 23, 2023
    Assignee: Promega Corporation
    Inventors: Brock Binkowski, Mary P. Hall, Thomas Machleidt, Joel Walker, Wenhui Zhou
  • NOVEL LUCIFERASE SEQUENCES UTILIZING INFRARED-EMITTING SUBSTRATES TO PRODUCE ENHANCED LUMINESCENCE
    Publication number: 20220186287
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Application
    Filed: March 1, 2022
    Publication date: June 16, 2022
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
    Patent number: 11293047
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: April 5, 2022
    Assignee: Promega Corporation
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • Compositions and methods for stabilizing benzothiazole luciferin analogs
    Patent number: 11136615
    Abstract: Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: October 5, 2021
    Assignee: PROMEGA CORPORATION
    Inventors: Ce Shi, Mary P. Hall, Thomas A. Kirkland, Lance P. Encell, Poncho Meisenheimer, Wenhui Zhou
  • 5,5-disubstituted luciferins and their use in luciferase-based assays
    Patent number: 10913972
    Abstract: Described are luciferin analogues, methods for making the analogues, kits including the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: February 9, 2021
    Assignee: Promega Corporation
    Inventors: Lance P. Encell, Mary P. Hall, Michael Killoran, Thomas A. Kirkland, Poncho Meisenheimer, Ce Shi
  • NOVEL LUCIFERASE SEQUENCES UTILIZING INFRARED-EMITTING SUBSTRATES TO PRODUCE ENHANCED LUMINESCENCE
    Publication number: 20200115735
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Application
    Filed: December 23, 2019
    Publication date: April 16, 2020
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • COELENTERAZINE ANALOGUES
    Publication number: 20200062766
    Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: August 22, 2019
    Publication date: February 27, 2020
    Inventors: Joel R. Walker, Thomas A. Kirkland, Wenhui Zhou, Mary P. Hall, Harry Tetsuo Uyeda
  • Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
    Patent number: 10550420
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: February 4, 2020
    Assignee: Promega Corporation
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • NANOLUC SUICIDE SUBSTRATES
    Publication number: 20190337939
    Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.
    Type: Application
    Filed: April 30, 2019
    Publication date: November 7, 2019
    Inventors: Brock Binkowski, Mary P. Hall, Thomas Machleidt, Joel Walker, Wenhui Zhou
  • 5,5-DISUBSTITUTED LUCIFERINS AND THEIR USE IN LUCIFERASE-BASED ASSAYS
    Publication number: 20190338340
    Abstract: Described are luciferin analogues, methods for making the analogues, kits including the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: July 19, 2019
    Publication date: November 7, 2019
    Inventors: Lance P. Encell, Mary P. Hall, Michael Killoran, Thomas A. Kirkland, Poncho Meisenheimer, Ce Shi
  • 5,5-disubstituted luciferins and their use in luciferase-based assays
    Patent number: 10400264
    Abstract: Described are luciferin analogs, methods for making the analogs, kits including the analogs, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: September 3, 2019
    Assignee: PROMEGA CORPORATION
    Inventors: Lance P. Encell, Mary P. Hall, Michael Killoran, Thomas A. Kirkland, Poncho Meisenheimer, Ce Shi
  • COMPOSITIONS AND METHODS FOR STABILIZING BENZOTHIAZOLE LUCIFERIN ANALOGS
    Publication number: 20190040449
    Abstract: Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of formula (I), and a liquid medium, in which the thionucleobase is present in an amount effective to stabilize the luminogenic composition against decomposition. The methods provided herein may stabilize the benzothiazole luciferin analog against decomposition by contacting the benzothiazole luciferin analog with an effective amount of the thionucleobase compound in the presence of a liquid medium. Also provided herein is a kit containing the composition.
    Type: Application
    Filed: August 2, 2018
    Publication date: February 7, 2019
    Inventors: Ce Shi, Mary P. Hall, Thomas A. Kirkland, Lance P. Encell, Poncho Meisenheimer, Wenhui Zhou
  • 5,5-DISUBSTITUTED LUCIFERINS AND THEIR USE IN LUCIFERASE-BASED ASSAYS
    Publication number: 20180155762
    Abstract: Described are luciferin analogues, methods for making the analogues, kits including the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 7, 2018
    Inventors: Lance P. Encell, Mary P. Hall, Michael Killoran, Thomas A. Kirkland, Poncho Meisenheimer, Ce Shi
  • NOVEL LUCIFERASE SEQUENCES UTILIZING INFRARED-EMITTING SUBSTRATES TO PRODUCE ENHANCED LUMINESCENCE
    Publication number: 20170314061
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Application
    Filed: July 10, 2017
    Publication date: November 2, 2017
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
    Patent number: 9732373
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: August 15, 2017
    Assignee: Promega Corporation
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • NOVEL LUCIFERASE SEQUENCES UTILIZING INFRARED-EMITTING SUBSTRATES TO PRODUCE ENHANCED LUMINESCENCE
    Publication number: 20160076079
    Abstract: Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
    Type: Application
    Filed: September 11, 2015
    Publication date: March 17, 2016
    Inventors: Lance P. Encell, Mary P. Hall, Keith V. Wood, Monika G. Wood
  • Thermostable luciferases and methods of production
    Patent number: 8822170
    Abstract: Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive mutagenesis. The luciferases are used in conventional methods, some employing kits.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: September 2, 2014
    Assignee: Promega Corporation
    Inventors: Keith V. Wood, Monika G. Wood, Mary P. Hall