Abstract: Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient or oral absorptivity or transcellular permeability of a compound by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the compound and comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

Abstract: Polydiacetylene (PDA) coatings are fabricated on porous membranes, specifically on membranes that have been pretreated or post treated by exposure to additional materials. In addition, the surface of the deposited diacetylene and PDA coatings can be modified.

Abstract: Supported three-dimensional arrays of a polydiacetylene backbone bonded to and supported by a solid support in a sample are provided. The bonding is achieved by providing a support having thiol and/or amine groups and epoxy groups and/or maleimide groups, and a polydiacetylene backbone containing the other of thiol and/or amine groups or the epoxy and/or maleimide groups for reacting with the corresponding thiol groups or epoxy groups and/or maleimide groups on the support; provided that when an amine is used the other group is an epoxy; and/or having a layer of a polyelectrolyte on the support; and/or having a multiple atom linker between the three-dimensional array of the polydiacetylene backbone and the solid support.

Abstract: Two-dimensional and/or three-dimensional polymeric or extended solid arrays comprising a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or ability of a compound to diffuse into cell membranes and/or transcellular permeability properties of a compound and/or the ionization state of a compound and/or the volume of distribution of a compound and/or the distribution of a compound into different tissues and/or the partitioning of a compound into cell organelles by monitoring the change in the fluorescence or phosphorescence upon exposure to the compound and optionally comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

Abstract: Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to screen a plurality of samples containing different species by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the sample and comparing it to a known change in fluorescence or phosphorescence, respectively.

Abstract: Two-dimensional and three-dimensional arrays of a polydiacetylene backbone having a substrate incorporated are used in chemical sensing methods to detect the interaction of an analyte with the substrate by monitoring the change in the fluorescence of the array.

Abstract: Two-dimensional and three-dimensional arrays of a polydiacetylene backbone having a substrate incorporated are used in chemical sensing methods to detect the interaction of an analyte with the substrate by monitoring the change in the fluorescence of the array.

Abstract: Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or transcellular permeability of a compound by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the compound and comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

Abstract: Two-dimensional and three-dimensional arrays of a polydiacetylene backbone having a substrate incorporated are used in chemical sensing methods to detect the interaction of an analyte with the substrate by monitoring the change in the fluorescence of the array.