Abstract: The present invention provides a composition containing an anti-acne effective amount of a combination of five components that work combinatorially to combat the acne condition as a whole. The compositions contain an anti-irritant component, an anti-inflammatory component, an adhesion inhibiting component, an sebum reducing component, and a sclareolide component. Both inflamed and non-inflamed lesions associated with the acne condition are reduced with a combination of the anti-irritant component, the anti-inflammatory component comprising at least a hoelen mushroom extract, the adhesion inhibiting component comprising at least a polysaccharide, the sebum reducing component comprising at least a pygeum extract, and the sclareolide component. The methods of the present invention treating the acne condition in a holistic manner.

Abstract: The present invention relates to a method of inhibiting angiogenesis in mammalian tissue which comprises supplying to the tissue a composition comprising an effective amount of epigallocatechin-gallate, epicatechin gallate or a combination thereof. The method is particularly useful in the treatment of angiogenesis-related skin conditions in which the catechin is applied topically, such as the treatment of various skin cancers, psoriasis, spider veins or undereye circles.

Abstract: The invention relates to topical cosmetic or pharmaceutical compositions comprising an anti-stinging effective amount of an amino acid selected from the group consisting of an amino butyric acid, glutamine, glycine, and derivatives thereof, or mixtures thereof, as well as methods of reducing or preventing stinging using such compositions.