Abstract: Methods of forming dispersible ferroelectric nanoparticles, including polyether-ylated barium titanate nanoparticles. Uses of the dispersible ferroelectric nanoparticles, including as a ferroelectric tracer material, optionally for detecting a presence and/or measuring a distribution of an oil or a hydrocarbon in a subsurface formation and/or flowback fluid. Compositions and methods involving an oil or hydrocarbon recovery fluid and the dispersible ferroelectric nanoparticles for detecting a presence, measuring a distribution, or both of an oil or a hydrocarbon in a subsurface formation and/or flowback fluid.

Abstract: The present invention relates to differentiation and tumorigenicity. The present invention more particularly relates to ligands which target CEA and CEACAM6 such that the adhesion, differentiation-Inhibitory activities and tumorigenic effects of Ig superfamily members, CEA and CEACAM6, can be reduced or blocked. More particularly, the present invention relates to CEA-binding agents which reverse CEA-mediated tumorigenic effects by declustering CEA and CEACAM6. In one embodiment the invention relates to methods of reducing, preventing or reversing a CEA-mediated tumorigenic effect comprising a use of a CEA-mediated tumorigenic effect reducing CEA-declustering agent. In one embodiment, the invention relates to compositions and use thereof for reversing CEA-mediated tumorigenic effects on human cancer cells and uses thereof.

Abstract: The present invention relates to a novel cancer therapy based on interference with the function or on downregulation of overproduced CEA/NCA, which plays an instrumental role in tumorigenesis and malignant progression through its differentiation-blocking activity. More precisely, there is provided three short amino acid sequence subdomains in the N domain of CEA and NCA that, when applied as peptides, peptide mimetics or anti-sudomain monoclonal antibodies to malignant tumors overproducing CEA/NCA, induce them to differentiate, thereby inhibiting their ability to grow and increasing the efficacy of other modes of treatment. Four other means of releasing the CEA/NCA-imposed differentiation block are also provided.