Patents by Inventor Marzia Monica Giuliani

Marzia Monica Giuliani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION NEISSERIAL COMPOSITIONS
    Publication number: 20150174231
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
    Type: Application
    Filed: May 21, 2014
    Publication date: June 25, 2015
    Applicant: NOVARTIS AG
    Inventors: Marzia Monica GIULIANI, Mariagrazia PIZZA, Rino RAPPUOLI
  • Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
    Patent number: 9057716
    Abstract: The disclosure provides compositions, methods and kits for assessing immunogenicity, potency, or both, of meningococcal capsular saccharide vaccines. The assessment is based upon measurement of binding of a bactericidal antibody to a capsular saccharide component in the vaccine.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: June 16, 2015
    Assignee: Novartis AG
    Inventors: Cristiana Balocchi, Enrico Luzzi, Marilena Paludi, Marzia Monica Giuliani, John Donnelly, Elena Mori
  • HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS
    Publication number: 20140363462
    Abstract: Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae are disclosed. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
    Type: Application
    Filed: July 31, 2014
    Publication date: December 11, 2014
    Inventors: Maria ARICÒ, Maurizio COMANDUCCI, Cesira GALEOTTI, Vega MASIGNANI, Marzia Monica GIULIANI, Mariagrazia PIZZA
  • HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS
    Publication number: 20140294885
    Abstract: Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae are disclosed. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 2, 2014
    Applicant: NOVARTIS AG
    Inventors: Maria Beatrice ARICO, Maurizio COMANDUCCI, Cesira GALEOTTI, Vega MASIGNANI, Marzia Monica GIULIANI, Mariagrazia PIZZA
  • COMBINATION NEISSERIAL COMPOSITIONS
    Publication number: 20140037668
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
    Type: Application
    Filed: June 18, 2013
    Publication date: February 6, 2014
    Inventors: Marzia Monica GIULIANI, Mariagrazia PIZZA, Rino RAPPUOLI
  • BACTERICIDAL ANTIBODY ASSAYS TO ASSESS IMMUNOGENICITY AND POTENCY OF MENINGOCOCCAL CAPSULAR SACCHARIDE VACCINES
    Publication number: 20130196352
    Abstract: The disclosure provides compositions, methods and kits for assessing immunogenicity, potency, or both, of meningococcal capsular saccharide vaccines. The assessment is based upon measurement of binding of a bactericidal antibody to a capsular saccharide component in the vaccine.
    Type: Application
    Filed: September 2, 2011
    Publication date: August 1, 2013
    Applicant: NOVARTIS AG
    Inventors: Cristiana Balocchi, Enrico Luzzi, Marilena Paludi, Marzia Monica Giuliani, John Donnelly, Elena Mori
  • Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870
    Patent number: 8398999
    Abstract: NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: March 19, 2013
    Assignee: Novartis AG
    Inventors: Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani
  • OUTER MEMBRANE VESICLE (OMV) VACCINE COMPRISING N. MENINGITIDIS SEROGROUP B OUTER MEMBRANE PROTEINS
    Publication number: 20120328643
    Abstract: A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.
    Type: Application
    Filed: August 21, 2012
    Publication date: December 27, 2012
    Applicant: NOVARTIS AG
    Inventors: Mariagrazia Pizza, Rino Rappuoli, Marzia Monica Giuliani
  • CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870
    Publication number: 20120283413
    Abstract: NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
    Type: Application
    Filed: July 23, 2012
    Publication date: November 8, 2012
    Applicant: NOVARTIS AG
    Inventors: Vega MASIGNANI, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani
  • Outer membrane vesicle (OMV) vaccine comprising serogroup B outer membrane proteins
    Patent number: 8273360
    Abstract: A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: September 25, 2012
    Assignee: Novartis AG
    Inventors: Mariagrazia Pizza, Rino Rappuoli, Marzia Monica Giuliani
  • Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870
    Patent number: 8226960
    Abstract: NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: July 24, 2012
    Assignee: Novartis AG
    Inventors: Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani
  • COMBINATION NEISSERIAL COMPOSITIONS
    Publication number: 20120135026
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 31, 2012
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Marzia Monica Giuliani, Mariagrazia Pizza, Rino Rappuoli
  • COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEIN AND PNEUMOCOCCAL SACCHARIDE CONJUGATES
    Publication number: 20120064103
    Abstract: An immunogenic composition comprising: (i) a conjugated pneumococcal capsular saccharide; and (ii) a meningococcal factor H binding protein (fHBP) antigen, and not including meningococcal outer membrane vesicles, is useful for immunising a subject against bacterial meningitis.
    Type: Application
    Filed: March 24, 2010
    Publication date: March 15, 2012
    Applicant: Novartis AG
    Inventors: Marzia Monica Giuliani, Paolo Ruggiero
  • CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870
    Publication number: 20110166323
    Abstract: NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
    Type: Application
    Filed: November 27, 2006
    Publication date: July 7, 2011
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani
  • COMBINATION NEISSERIAL COMPOSITIONS
    Publication number: 20110104193
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
    Type: Application
    Filed: December 27, 2010
    Publication date: May 5, 2011
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Marzia Monica GIULIANI, Mariagrazia PIZZA, Rino RAPPUOLI
  • Hybrid Polypeptides Including Meningococcal fHBP Sequences
    Publication number: 20110076300
    Abstract: fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
    Type: Application
    Filed: August 27, 2010
    Publication date: March 31, 2011
    Inventors: Mariagrazia Pizza, Maria Scarselli, Marzia Monica Giuliani, Maria Arico, Rino Rappuoli
  • MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20110020390
    Abstract: fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.
    Type: Application
    Filed: February 20, 2009
    Publication date: January 27, 2011
    Inventors: Mariagrazia Pizza, Maria Scarselli, Marzia Monica Giuliani, Maria Arico, Rino Rappuoli
  • Methods and Compositions Relating to Adhesins as Adjuvants
    Publication number: 20110008279
    Abstract: This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells.
    Type: Application
    Filed: December 6, 2006
    Publication date: January 13, 2011
    Inventors: Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani
  • Combination neisserial compositions
    Patent number: 7862827
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: January 4, 2011
    Assignee: Novartis Vaccines and Diagnostics SRL
    Inventors: Marzia Monica Giuliani, Mariagrazia Pizza, Rino Rappuoli
  • 85kDa neisserial antigen
    Patent number: 7700119
    Abstract: An 85 kDa antigen from Neisseria meningitidis and Neisseria gonorrhoeae has been cloned, sequenced and expressed. The antigen is common to diverse strains, serogroups and serotypes of N. meningitidis, and also to N. gonorrhoeae, N. polysaccharia and N. lactamica. The protein sequences of N. meningitidis (serogroups A and B) and N. gonorrhoeae are highly homologous.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: April 20, 2010
    Assignee: Novartis Vaccines and Diagnostics SRL
    Inventors: Marzia Monica Giuliani, Mariagrazia Pizza, Rino Rappuoli, Johan Holst