Patents by Inventor Masaaki Hirose
Masaaki Hirose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230312570Abstract: Provided is a method which is for preparing a morphinan derivative having a diaryl ether skeleton represented by general formula (III) (In the formula, R1 represents a hydrogen atom, etc., R2, R3, and R4 are the same or different and each represent a hydrogen atom, or an arbitrary substituent, etc., R5 represent a hydrogen atom, a hydroxy group, etc., R14 and R15 are the same or different and each represent a hydrogen atom, or an arbitrary substituent, etc.), and in which a phenyl group is introduced into the 4-position phenol of a morphinan derivative through the Ullmann reaction of a system using a monovalent copper compound or a novel catalytic system simultaneously using a monovalent copper compound and zero-valent metallic copper.Type: ApplicationFiled: August 27, 2021Publication date: October 5, 2023Applicant: NIPPON CHEMIPHAR CO., LTD.Inventor: Masaaki HIROSE
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Publication number: 20230159530Abstract: A morphinan derivative represented by the following general formula (I): wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R2; R3, R4, and R5 represent hydrogen, hydroxy, etc.; R6a and R6b represent hydrogen, etc.; R7 and R8 represent hydrogen, etc.; R9 and R10, which are the same or different, represent hydrogen, etc.; X represents O or CH2; and Y represents C(?O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.Type: ApplicationFiled: January 9, 2023Publication date: May 25, 2023Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
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Patent number: 11643411Abstract: A morphinan derivative represented by the following general formula (I): wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R2; R3, R4, and R5 represent hydrogen, hydroxy, etc.; R6a and R6b represent hydrogen, etc.; R7 and R8 represent hydrogen, etc.; R9 and R10, which are the same or different, represent hydrogen, etc.; X represents O or CH2; and Y represents C(?O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.Type: GrantFiled: October 13, 2020Date of Patent: May 9, 2023Assignee: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi Nagase, Hideaki Fujii, Akiyoshi Saitoh, Eriko Nakata, Masaaki Hirose, Isao Ooi, Kohei Hayashida
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Publication number: 20230132191Abstract: A method for therapeutic treatment of pain-associated anxiety or depression in a mammalian subject in need thereof, that includes administering to the subject an effective amount of a pharmaceutical composition containing a morphinan derivative that exhibits an opioid ? receptor agonist activity.Type: ApplicationFiled: December 15, 2022Publication date: April 27, 2023Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
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Patent number: 11633392Abstract: The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid ? receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid ? receptor-related diseases (for example, headache) can be treated or prevented.Type: GrantFiled: September 15, 2017Date of Patent: April 25, 2023Assignee: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi Nagase, Hideaki Fujii, Akiyoshi Saitoh, Eriko Nakata, Masaaki Hirose, Isao Ooi, Kohei Hayashida
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Publication number: 20220289748Abstract: Provided is a method for producing a phenol derivative represented by General Formula (B) and the like, including the step of: allowing metal lithium and liquid ammonia or a primary amine to act on a compound represented by General Formula (A) and the like: wherein Rp1 represents a C6-10 aryl group optionally having a substituent, Rp2 represents a lower alkyl group and the like, and Rq1, Rq2, Rq3, and Rq4 represent a hydrogen atom or any substituent, or adjacent two of Rq1, Rq2, Rq3, and Rq4 optionally form a ring.Type: ApplicationFiled: July 17, 2020Publication date: September 15, 2022Applicant: NIPPON CHEMIPHAR CO., LTD.Inventor: Masaaki HIROSE
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Patent number: 11420944Abstract: A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: wherein A represents a 5-membered heteroaryl group or a fused ring of a 5-membered or 6-membered heterocyclic ring with a benzene ring or a pyridine ring, each of which may have a substituent; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent, or the like; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2.Type: GrantFiled: January 12, 2017Date of Patent: August 23, 2022Assignees: Nippon Chemiphar Co., Ltd., Kinki UniversityInventors: Hiroto Tanaka, Isao Ooi, Yuzo Mogi, Masaaki Hirose, Tsuyoshi Endo, Toru Ogawa, Atsufumi Kawabata
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Publication number: 20210371422Abstract: A compound represented by the following general formula (I), wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms and the alkylene moiety has 1 to 5 carbon atoms, or the like, R2 represents a 4- to 7-membered saturated heterocycle containing one or two heteroatoms which may be the same or different and are selected from N, O, and S, and two or more carbon atoms as ring-constituting atoms, the heterocycle may be substituted with a substituent such as an oxo group, R2 binds to Y via a carbon atom as a ring-constituting atom of R2, R3, R4, and R5, which are the same or different, represent hydrogen; hydroxy; or the like, R6a and R6b, which are the same or different, represent hydrogen or the like, R7 and R8, which are the same or different, represent hydrogen or the like, R9 and R10, which are the same or different, represent hydrogen or the like, X represents O or CH2, and Y represents C(?O) or the like), a tautomer of the compound, a stereoisomeType: ApplicationFiled: August 8, 2017Publication date: December 2, 2021Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
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Patent number: 11176749Abstract: An imaging unit captures an image of a visual field. A detector detects a position of an eyeball and a sight line of an occupant. A visual point identifier identifies a position of a visual point of the occupant in the visual field, the eye position and the sight line direction. A measuring unit measures a position and a distance of an object included in the image of the visual field. An image generator generates display images based on the eye position and the position and the distance of the object. The display images are displayed on a virtual plane, fused on a fusion plane and displayed as a three-dimensional display on the visual field. The display images are generated to display the three-dimensional image at a given magnification ratio calculated by reducing a geometric display magnification ratio as the distance from the occupant increases.Type: GrantFiled: March 4, 2020Date of Patent: November 16, 2021Assignee: DENSO CORPORATIONInventors: Toshiyuki Kondo, Fumihiko Murase, Masaaki Hirose, Kazunori Higuchi, Yuji Muragishi
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Publication number: 20210300183Abstract: An in-vehicle display apparatus includes: an image generating unit, an emitting unit, and a reflecting unit. The image generating unit generates, for display information that is presented to a user, an image that includes a right-eye image and a left-eye image with a parallax. The emitting unit emits a projection light that is a light flux that contains the image. The reflecting unit reflects the projection light and forms a stereoscopic image that is superimposed on an outside view. The image generating unit generates the image in which a fusion distance of the stereoscopic image of the display information is changed, within a predetermined period of time, from a current visual distance to a target distance at which the display information is to be ultimately displayed.Type: ApplicationFiled: March 26, 2021Publication date: September 30, 2021Inventors: Toshiyuki KONDO, Fumihiko MURASE, Masaaki HIROSE, Kazunori HIGUCHI, Yuji MURAGISHI, Toshiyuki TAGUCHI, Yoshikazu HATTORI
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Patent number: 11011062Abstract: A target pedestrian who is present within a range of a predetermined distance from a roadway is detected. Whether or not the target pedestrian has gazed at a crossing destination and whether or not the target pedestrian has performed a safety confirmation regarding vehicles traveling on the roadway are determined based on a gaze direction of the target pedestrian. As a result, when the target pedestrian has performed one action of either of gazing at the crossing destination and the safety confirmation, and then performed the other action within a predetermined amount of time, the target pedestrian is detected as a pre-crossing pedestrian who has an intention to cross the roadway. Consequently, a pedestrian who is attempting to cross the roadway can be accurately detected at a stage before the pedestrian actually starts crossing.Type: GrantFiled: June 5, 2017Date of Patent: May 18, 2021Assignee: DENSO CORPORATIONInventors: Shinya Kitayama, Hirokazu Oyabu, Masaaki Hirose, Toshiyuki Kondo, Tadashi Kamada
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Patent number: 10995092Abstract: A morphinan derivative represented by the following general formula (I): wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R2; R3, R4, and R5 represent hydrogen, hydroxy, etc.; R6a and R6b represent hydrogen, etc.; R7 and R8 represent hydrogen, etc.; R9 and Rio, which are the same or different, represent hydrogen, etc.; X represents O or CH2; and Y represents C(?O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.Type: GrantFiled: July 19, 2019Date of Patent: May 4, 2021Assignee: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi Nagase, Eriko Nakata, Masaaki Hirose, Isao Ooi
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Publication number: 20210040094Abstract: A morphinan derivative represented by the following general formula (I): wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R2; R3, R4, and R5 represent hydrogen, hydroxy, etc.; R6a and R6b represent hydrogen, etc.; R7 and R9 represent hydrogen, etc.; R9 and R10, which are the same or different, represent hydrogen, etc.; X represents O or CH2; and Y represents C(?O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.Type: ApplicationFiled: October 13, 2020Publication date: February 11, 2021Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
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Publication number: 20200286292Abstract: An imaging unit captures an image of a visual field. A detector detects a position of an eyeball and a sight line of an occupant. A visual point identifier identifies a position of a visual point of the occupant in the visual field, the eye position and the sight line direction. A measuring unit measures a position and a distance of an object included in the image of the visual field. An image generator generates display images based on the eye position and the position and the distance of the object. The display images are displayed on a virtual plane, fused on a fusion plane and displayed as a three-dimensional display on the visual field. The display images are generated to display the three-dimensional image at a given magnification ratio calculated by reducing a geometric display magnification ratio as the distance from the occupant increases.Type: ApplicationFiled: March 4, 2020Publication date: September 10, 2020Inventors: Toshiyuki KONDO, Fumihiko MURASE, Masaaki HIROSE, Kazunori HIGUCHI, Yuji MURAGISHI
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Publication number: 20200079775Abstract: A morphinan derivative represented by the following general formula (I): wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc.; R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group; Y binds to a carbon atom as a ring-constituting atom of R2; R3, R4, and R5 represent hydrogen, hydroxy, etc.; R6a and R6b represent hydrogen, etc.; R7 and R8 represent hydrogen, etc.; R9 and Rio, which are the same or different, represent hydrogen, etc.; X represents O or CH2; and Y represents C(?O)); a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.Type: ApplicationFiled: July 19, 2019Publication date: March 12, 2020Applicant: NIPPON CHEMIPHAR CO., LTDInventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
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Publication number: 20190328725Abstract: The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid ? receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid ? receptor related diseases (for example, headache) can be treated or prevented.Type: ApplicationFiled: September 15, 2017Publication date: October 31, 2019Applicant: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
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Patent number: 10442802Abstract: A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(?O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.Type: GrantFiled: March 17, 2016Date of Patent: October 15, 2019Assignee: NIPPON CHEMIPHAR CO., LTD.Inventors: Hiroshi Nagase, Hideaki Fujii, Akiyoshi Saitoh, Eriko Nakata, Masaaki Hirose, Isao Ooi, Kohei Hayashida
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Publication number: 20190213887Abstract: A target pedestrian who is present within a range of a predetermined distance from a roadway is detected. Whether or not the target pedestrian has gazed at a crossing destination and whether or not the target pedestrian has performed a safety confirmation regarding vehicles traveling on the roadway are determined based on a gaze direction of the target pedestrian. As a result, when the target pedestrian has performed one action of either of gazing at the crossing destination and the safety confirmation, and then performed the other action within a predetermined amount of time, the target pedestrian is detected as a pre-crossing pedestrian who has an intention to cross the roadway. Consequently, a pedestrian who is attempting to cross the roadway can be accurately detected at a stage before the pedestrian actually starts crossing.Type: ApplicationFiled: June 5, 2017Publication date: July 11, 2019Applicant: DENSO CORPORATIONInventors: Shinya KITAYAMA, Hirokazu OYABU, Masaaki HIROSE, Toshiyuki KONDO, Tadashi KAMADA
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Publication number: 20190077767Abstract: A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: wherein A represents a fused ring which may have a substituent, the fused ring being composed of a 5-membered heteroaryl group or a 5-membered or 6-membered heterocyclic ring and a benzene ring or the like, the 5-membered heteroaryl group having one to three identical or different heteroatoms as a ring-constituting element(s) having at least one substituent such as an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 5 halogen atoms; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represType: ApplicationFiled: January 12, 2017Publication date: March 14, 2019Applicants: Nippon Chemiphar Co., Ltd., Kinki UniversityInventors: Hiroto TANAKA, Isao OOI, Yuzo MOGI, Masaaki HIROSE, Tsuyoshi ENDO, Toru OGAWA, Atsufumi KAWABATA
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Patent number: 10144742Abstract: This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R4, Rq, o, RA, and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease.Type: GrantFiled: April 17, 2015Date of Patent: December 4, 2018Assignee: Millennium Pharmaceuticals, Inc.Inventors: Kenneth M. Gigstad, David P. Cardin, Takaharu Hirayama, Masaaki Hirose, Yongbo Hu, Hiroyuki Kakei, Hong Myung Lee, Takashi Motoyaji, Noriyuki Nii, Zhan Shi, Stepan Vyskocil, Hiroyuki Watanabe