Patents by Inventor Masaaki Kosaka
Masaaki Kosaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11973312Abstract: A semiconductor laser device comprises a stem serving as a base; a laser diode LD submount having surface electrodes arranged thereon and joined to the surface of the stem; an LD chip joined to the surface electrode and connected with the surface electrode; and leads fixed in through holes formed in the stem by means of sealing parts and electrically connected to the surface electrodes via embedded layers in via holes formed in the LD submount, wherein grooves are formed in portions of the sealing parts or in portions of the LD submount around the connections between the leads and the embedded layers, to obtain a good modulated light waveform.Type: GrantFiled: July 2, 2019Date of Patent: April 30, 2024Assignee: Mitsubishi Electric CorporationInventors: Naoki Kosaka, Ayumi Fuchida, Masaaki Shimada, Go Sakaino, Tadashi Takase
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Patent number: 8834876Abstract: An inducing agent or enhancing agent, for the expression of HM1.24 antigen in hematopoietic tumor cells, comprising interferon ?, interferon ?, or the IRF-2 protein as an active ingredient, as well as an antitumor agent for hematopoietic tumors which comprises a combination of said inducing agent or enhancing agent and an antibody against HM1.24.Type: GrantFiled: April 13, 2011Date of Patent: September 16, 2014Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masaaki Kosaka, Shuji Ozaki, Yuji Wakahara
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Patent number: 8652839Abstract: A cancer vaccine containing as an active ingredient an antigen-specific dendritic cell pulsed by an HM1.24 protein, HM1.24 peptide or transduced with an HM1.24-encoding gene, or HM1.24 protein-encoding DNA or RNA.Type: GrantFiled: October 30, 2003Date of Patent: February 18, 2014Assignees: Chugai Seiyaku Kabushiki Kaisha, University College LondonInventors: Yong Kwee, Masaaki Kosaka, Yasuo Koishihara
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Patent number: 8287863Abstract: An enhancer of expression, in the myeloma cell, of HM1.24 antigen, said enhancer comprising interferon-? or interferon-?, or IRF-2 protein as an active ingredient. Interferon-? or interferon-? is expected to enhance the expression of HM1.24 antigen by activating the promoter of a gene encoding HM1.24 antigen.Type: GrantFiled: April 13, 2006Date of Patent: October 16, 2012Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masaaki Kosaka, Shuji Ozaki, Yuji Wakahara
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Publication number: 20110223133Abstract: An inducing agent or enhancing agent, for the expression of HM1.24 antigen in hematopoietic tumor cells, comprising interferon ?, interferon ?, or the IRF-2 protein as an active ingredient, as well as an antitumor agent for hematopoietic tumors which comprises a combination of said inducing agent or enhancing agent and an antibody against HM1.24.Type: ApplicationFiled: April 13, 2011Publication date: September 15, 2011Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Masaaki KOSAKA, Shuji Ozaki, Yuji Wakahara
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Patent number: 7931897Abstract: An inducing agent or enhancing agent, for the expression of HM1.24 antigen in hematopoietic tumor cells, comprising interferon ?, interferon ?, or the IRF-2 protein as an active ingredient, as well as an anti-tumor agent for hematopoietic tumors which comprises a combination of said inducing agent or enhancing agent and an antibody against HM1.24.Type: GrantFiled: February 6, 2002Date of Patent: April 26, 2011Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masaaki Kosaka, Shuji Ozaki, Yuji Wakahara
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Patent number: 7892543Abstract: The invention provides a reshaped human anti-HM 1.24 antibody having: (A) an L chain having (1) the C region of a human L chain, and (2) the V region of an L chain having the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain having (1) the C region of a human H chain, and (2) the V region of an H chain having the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. This reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, and the reshaped human antibody of the present invention has a low antigenicity and can be used for medical treatment.Type: GrantFiled: August 13, 2002Date of Patent: February 22, 2011Assignee: Chugai Seiyako Kabushiki KaishaInventors: Koichiro Ono, Toshihiko Ohtomo, Masayuki Tsuchiya, Yasushi Yoshimura, Yasuo Koishihara, Masaaki Kosaka
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Patent number: 7790152Abstract: An enhancer, for treatment of lymphocytic tumors, of an antibody that specifically binds to protein having the amino acid sequence as set forth in SEQ ID NO: 1 and that has a cytotoxic activity, said enhancer comprising a biological response modifier as an active ingredient.Type: GrantFiled: May 2, 2003Date of Patent: September 7, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masaaki Kosaka, Yasuo Koishihara
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Publication number: 20060193828Abstract: An enhancer of expression, in the myeloma cell, of HM1.24 antigen, said enhancer comprising interferon-? or interferon-?, or IRF-2 protein as an active ingredient. Interferon-? or interferon-? is expected to enhance the expression of HM1.24 antigen by activating the promoter of a gene encoding HM1.24 antigen.Type: ApplicationFiled: April 13, 2006Publication date: August 31, 2006Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Masaaki Kosaka, Shuji Ozaki, Yuji Wakahara
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Publication number: 20060153883Abstract: A cancer vaccine containing as an active ingredient an antigen-specific dendritic cell pulsed by an HM1.24 protein, HM1.24 peptide or transduced with an HM1.24-encoding gene, or HM1.24 protein-encoding DNA or RNA.Type: ApplicationFiled: October 30, 2003Publication date: July 13, 2006Inventors: Yong Kwee, Masaaki Kosaka, Yasuo Koishihara
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Publication number: 20060078539Abstract: An inducing agent or enhancing agent, for the expression of HM1.24 antigen in hematopoietic tumor cells, comprising interferon ?, interferon ?, or the IRF-2 protein as an active ingredient, as well as an anti-tumor agent for hematopoietic tumors which comprises a combination of said inducing agent or enhancing agent and an antibody against HM1.24.Type: ApplicationFiled: February 6, 2002Publication date: April 13, 2006Inventors: Masaaki Kosaka, Shuji Ozaki, Yuji Wakahara
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Patent number: 6908750Abstract: There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.Type: GrantFiled: April 25, 2003Date of Patent: June 21, 2005Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toshihiko Ohtomo, Masayuki Tsuchiya, Yasuo Koishihara, Masaaki Kosaka
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Patent number: 6699974Abstract: A reshaped human anti-HM 1.24 antibody comprising: (A) an L chain comprising (1) the C region of a human L chain, and (2) the V region of an L chain comprising the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain comprising (1) the C region of a human H chain, and (2) the V region of an H chain comprising the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. Since most of this reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, the reshaped human antibody of the present invention has a low antigenicity and, therefore, is expected to be-used for medical treatment.Type: GrantFiled: April 1, 1999Date of Patent: March 2, 2004Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Koichiro Ono, Toshihiko Ohtomo, Masayuki Tsuchiya, Yasushi Yoshimura, Yasuo Koishihara, Masaaki Kosaka
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Publication number: 20030180889Abstract: There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.Type: ApplicationFiled: April 25, 2003Publication date: September 25, 2003Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Toshihiko Ohtomo, Masayuki Tsuchiya, Yasuo Koishihara, Masaaki Kosaka
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Publication number: 20030175281Abstract: An enhancer, for treatment of lymphocytic tumors, of an antibody that specifically binds to protein having the amino acid sequence as set forth in SEQ ID NO: 1 and that has a cytotoxic activity, said enhancer comprising a biological response modifier as an active ingredient.Type: ApplicationFiled: May 2, 2003Publication date: September 18, 2003Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Masaaki Kosaka, Yasuo Koishihara
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Patent number: 6613546Abstract: There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.Type: GrantFiled: August 14, 2000Date of Patent: September 2, 2003Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toshihiko Ohtomo, Masayuki Tsuchiya, Yasuo Koishihara, Masaaki Kosaka
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Patent number: 6602663Abstract: A method of detecting or determining plasmacytoma cells in a sample, said method comprising amplifying a polynucleotide that is specifically or strongly expressed in said plasmacytoma cells, and then detecting or measuring the amplified product.Type: GrantFiled: March 16, 2001Date of Patent: August 5, 2003Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Shigeto Kawai, Yasuo Koishibara, Masaaki Kosaka
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Publication number: 20030129185Abstract: A reshaped human anti-HM 1.Type: ApplicationFiled: August 13, 2002Publication date: July 10, 2003Inventors: Koichiro Ono, Toshihiko Ohtomo, Masayuki Tsuchiya, Yasushi Yoshimura, Yasuo Koishihara, Masaaki Kosaka