Abstract: The present invention provides uses of a polypeptide having a ligand activity to a sensory epithelium neuropeptide-like receptor (SENR) which is a G protein-coupled receptor protein, and a DNA encoding the same. More specifically, the present invention provides an anti-attention-deficit-disorder or anti-narcolepsy agent, which comprises a polypeptide having a ligand activity for SENR or a salt thereof, as well as a method for screening compounds having an anti-attention-deficit-disorder or anti-narcolepsy activity or compounds having an anti-anxiety, anti-depression, anti-insomnia, anti-schizophrenia or anti-fear activity or salts thereof, which comprises using the above polypeptide or a precursor protein of the polypeptide or a salt thereof.

Abstract: The present invention intends to provide a novel protein useful for a screening of agonists/antagonists. Specifically, the present invention provides rat- and mouse-derived protein or its salt, DNA encoding the protein, a determination method of ligand to the protein, a screening method and a screening kit for a compound that alters a binding property between ligand and the protein, a compound or its salt obtainable by the screening, and the like.

Abstract: According to the present invention, there are provided compounds represented by formula (I): 1

Abstract: A prophylactic or therapeutic agent for central nervous system diseases based on amyloid &bgr;40 secretion inhibitory activity of a compound having urotensin II receptor antagonistic activity or a salt thereof.

Abstract: In an isotopic gas analyzer, a gas injector (21) is provided for pressurizing a gas specimen in cells (11a,11b). The pressurization of the gas specimen virtually produces the same effect as increasing the concentration of carbon dioxide in the gas specimen, thereby improving an S/N ratio for the analysis and hence data reproducibility.

Abstract: A vasoactive drug is provided which comprises a compound having GPR14-antagonizing activity or salts thereof.

Abstract: In a test strip measuring method in which a coloration measurement is conducted while a test strip (4) is being moved, there are detected the optical characteristics R of the ground of a test strip and the optical characteristics T of a test line (4b) which has appeared on the test strip, and the test strip is judged based on the difference or ratio between R and T. Even though the ground of the test strip presents variations in optical characteristics, and even though there are variations among samples or among test strips, such variations can be absorbed, thus assuring an accurate judgment.

Abstract: A portable terminal device of an advertisement medium in an advertisement providing system has the function of storing advertising information and the function of performing wireless communications such as Bluetooth, etc. When a consumer finds a person having interesting goods on or with him or her, the consumer requests to transmit information by wireless through a portable terminal. The portable terminal device of an advertisement medium receives the request to transmit the advertising information, and transmits the advertising information about the goods the advertisement medium has on or with. The advertisement medium has gained user entry in advance. Thus, the consumer can immediately obtain the advertising information about the goods which has been found in the street and interested the consumer.

Abstract: A test gas sample containing carbon dioxide 13CO2 as a component gas is introduced into a cell, then the absorbance of light transmitted therethrough at a wavelength suitable for the component gas 13CO2 is determined, and the concentration of the component gas is determined on the basis of a calibration curve prepared through measurement on test gas samples each containing the component gas in a known concentration. Further, the concentration of water vapor contained in the test gas sample is measured, and the concentration of the component gas in the test gas sample is corrected in accordance with the measured water vapor concentration on the basis of a correction curve prepared through measurement on the test gas samples each containing water vapor in a known concentration (FIG. 4). With the spectrometry, the concentration ratio of the component gas can precisely be determined and corrected by measuring the moisture content in the test gas sample.

Abstract: A test gas sample containing carbon dioxide 13CO2 as a component gas is introduced into a cell, then the absorbance of light transmitted therethrough at a wavelength suitable for the component gas 13CO2 is determined, and the concentration of the component gas is determined on the basis of a calibration curve prepared through measurement on test gas samples each containing the component gas in a known concentration. Further, the concentration of water vapor contained in the test gas sample is measured, and the concentration of the component gas in the test gas sample is corrected in accordance with the measured water vapor concentration on the basis of a correction curve prepared through measurement on the test gas samples each containing water vapor in a known concentration (FIG. 4). With the spectrometry, the concentration ratio of the component gas can precisely be determined and corrected by measuring the moisture content in the test gas sample.

Abstract: An electronic mail system that is used to send electronic mail with an attached file reliably regardless of the status of mail servers on a transmission path. In this electronic mail system, if an attached file is added to electronic mail sent from a mail client, being a sender, an attached file separating section separates the attached file from the electronic mail. An attached file transferring section transfers the attached file separated from the electronic mail by the attached file separating section to an FTP server. A store location information adding section adds store location information indicating a location where the attached file transferred by the attached file transferring section is stored to the electronic mail. The electronic mail to which the store location information has been added is sent to a receiver mail server.

Abstract: In accordance with the present invention, a test gas sample containing carbon dioxide 13CO2 as a component gas is introduced into a cell, then the absorbance of light transmitted therethrough at a wavelength suitable for the component gas 13CO2 is determined, and the concentration of the component gas is determined on the basis of a calibration curve prepared through measurement on test gas samples each containing the component gas in a known concentration. Further, the concentration of water vapor contained in the test gas sample is measured, and the concentration of the component gas in the test gas sample is corrected in accordance with the measured water vapor concentration on the basis of a correction curve prepared through measurement on the test gas samples each containing water vapor in a known concentration. With the spectrometry, the concentration ratio of the component gas can precisely be determined and corrected by measuring the moisture content in the test gas sample.

Abstract: A correction curve (FIG. 19) is prepared by plotting 12CO2 concentrations and 13CO2/12CO2 concentration ratios which are determined on the basis of a calibration curve and 13CO2 and 12CO2 absorbances of gaseous samples having the same 13CO2/12CO2 concentration ratio but known different 12CO2 concentrations. A gaseous test sample containing 13CO2 and 12CO2 as component gases is introduced into a cell, and spectrometrically measured. A 12CO2 concentration of the gaseous test sample is determined by way of the spectrometric measurement. A concentration ratio correction value is obtained on the basis of the correction curve and the 12CO2 concentration of the gaseous test sample thus determined. A measured 13CO2/12CO2 concentration ratio is divided by the concentration ratio correction value thus obtained for correction of the 13CO2/12CO2 concentration ratio. Thus, the measurement accuracy of the concentration ratios of the component gases can be improved.

Abstract: A correction curve (FIG. 19) is prepared by plotting .sup.12 CO.sub.2 concentrations and .sup.13 CO.sub.2 /.sup.12 CO.sub.2 concentration ratios which are determined on the basis of a calibration curve and .sup.13 CO.sub.2 and .sup.12 CO.sub.2 absorbances of gaseous samples having the same .sup.13 CO.sub.2 /.sup.12 CO.sub.2 concentration ratio but known different .sup.12 CO.sub.2 concentrations. A gaseous test sample containing .sup.13 CO.sub.2 and .sup.12 CO.sub.2 as component gases is introduced into a cell, and spectrometrically measured. A .sup.12 CO.sub.2 concentration of the gaseous test sample is determined by way of the spectrometric measurement. A concentration ratio correction value is obtained on the basis of the correction curve and the .sup.12 CO.sub.2 concentration of the gaseous test sample thus determined. A measured .sup.13 CO.sub.2 /.sup.12 CO.sub.2 concentration ratio is divided by the concentration ratio correction value thus obtained for correction of the .sup.13 CO.sub.2 /.sup.12 CO.sub.

Abstract: An apparatus for automatically switching of connection of conduit pipes to clean the pipe lines in a liquid treating plant, to control centrally the automatically switching from a remote place, portions to be washed by a cleaning liquid and the other portions desired to be kept free from a cleaning liquid being separated, the apparatus comprizing a plurality of pipes (11a, 11b, 11c, 11d) of pipe lines which have openings on a circle on a fixed plate (10), switching pipes (17a, 17b) connecting the pipes (11a, 11b, 11c, 11d) to each other at the openings, nozzles (34) to spray a cleaning liquid toward the switching portions of pipes being located in an axis of the circle, the switching pipes and nozzles being substantially arranged in a body and covered with a cover (45), and on the opposite side of the fixed plate (10) where a spraying cleaning liquid is shut by the fixed plate, a drive mechanism (2) which switches the connection of pipes by linearly reciprocating and rotating the switching pipes and nozzles i

Abstract: A phosphonic acid derivative compound represented by formula [I ] or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R.sub.2 is unsubstituted methyl, ( 2 ) R.sub.3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R.sub.1 is benzyloxycarbonylaminomethyl, R.sub.2 is isobutyl and R.sub.3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.

Abstract: A system for driving a thermal print head including a plurality of heat-producing elements which are activated selectively in accordance with digital image data obtained from an analog image signal is provided. In one aspect, the driving system is so structured to insert additional data between any two adjacent image data whenever the space between the two exceeds a predetermined level thereby allowing to maintain the dot density at constant when printed. In another aspect, the driving system controls the time period of activation of each of the heat-producing elements in accordance with preheat control data obtained by carrying out AND processing between each of the digital image data of one print line and the corresponding each of the digital image data of the next following print line. In a further aspect, the present driving system has a structure such that a reference point in a print line may be set at a desired location along the print line.

Abstract: A pattern memory for use in a thermal printer system stores a temperature-compensated pattern of a character to be printed on recording paper using a thermal print head having a plurality of heat-producing elements arranged in a single array is provided. The pattern is defined in the form of a dot matrix, each dot containing two or more binary data, each of which, if having a predetermined one of the two possible states, is associated with a predetermined activation time period for activating one of the heat-producing elements. The binary state of each of the two or more data in each dot is determined such that a level of heat produced by any of the heat-producing elements may be maintained at constant. In one embodiment having two binary data in each dot, the pattern is determined such that the one of the two data of a dot has "0" and the other has "1" if this dot is to be printed for a second time or more by the same heat-producing element in succession.

Abstract: A system for driving a thermal print head including a plurality of heat-producing elements which are activated selectively in accordance with digital image data obtained from an analog image signal is provided. In one aspect, the driving system is so structured to insert additional data between any two adjacent image data whenever the space between the two exceeds a predetermined level thereby allowing to maintain the dot density at constant when printed. In another aspect, the driving system controls the time period of activation of each of the heat-producing elements in accordance with preheat control data obtained by carrying out AND processing between each of the digital image data of one print line and the corresponding each of the digital image data of the next following print line. In a further aspect, the present driving system has a structure such that a reference point in a print line may be set at a desired location along the print line.

Abstract: A phosphonic acid derivative compound represented by formula ?I ! or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R.sub.2 is unsubstituted methyl, ( 2 ) R.sub.3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R.sub.1 is benzyloxycarbonylaminomethyl, R.sub.2 is isobutyl and R.sub.3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.This is a Reissue of a Patent which was the subject of a Reexamination Certificate No. B1 5,330,978, dated Jun. 18, 1996, Request No. 90/00400, Oct. 18, 1995.