Patents by Inventor Masaaki Murakami

Masaaki Murakami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210405011
    Abstract: The present invention pertains to a medicine, said medicine comprising as an active ingredient a substance which suppresses the expression of at least one molecule selected from the group consisting of TMEM5, VSTM2L, C2CDD4D, VSTM2A, LY6G6C and ADRA2C or inhibits the activity thereof, for preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death. Also, the present invention pertains to a method for screening a substance, which is capable of preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death, with the use of the expression or activity of the aforesaid molecule as an index.
    Type: Application
    Filed: September 2, 2019
    Publication date: December 30, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Masaaki Murakami, Daisuke Kamimura
  • Publication number: 20210274679
    Abstract: A fan-equipped heatsink includes: a heat receiving substrate made of metal; a centrifugal fan disposed on an upper surface side of the heat receiving substrate; a plate-shaped wall that is made of metal, is provided so as to stand at a position, on the upper surface of the heat receiving substrate, which is around and opposed to an outer peripheral portion having an air discharge opening of the centrifugal fan, and are provided with a plurality of through-holes that are open in a plate surface opposed to the centrifugal fan; and a lid member fixed to an upper end of the plate-shaped wall 4 and configured to close a space on the inner side of the plate-shaped wall.
    Type: Application
    Filed: September 4, 2019
    Publication date: September 2, 2021
    Applicant: Lotus Thermal Solution Inc.
    Inventors: Takuya IDE, Masaaki MURAKAMI, Tomiyuki NUMATA
  • Publication number: 20210032633
    Abstract: [Problem] The purpose of the present invention is to provide new treatment targets and treatment methods for chronic inflammatory disease based on a molecular biological mechanism relating to the onset of keloid. [Solution] The present invention relates to a drug for the prevention and/or treatment of chronic inflammatory disease that contains as an active ingredient a substance that suppresses the expression and/or inhibits the activity of a specific NEDD4 splicing variant protein.
    Type: Application
    Filed: February 4, 2018
    Publication date: February 4, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Masaaki Murakami, Daisuke Kamimura, Munekumi Fujita
  • Publication number: 20200148986
    Abstract: This ultrasonic-wave vibration imparting device is configured so as to be attachable to a container that retains a beverage and that has a spout on an upper part thereof. The ultrasonic-wave vibration imparting device includes: an annular engagement part configured so as to engage with the upper part of the container; and an ultrasonic wave generating unit configured so as to be disposed at a position at which the unit comes into contact with a side surface of the container below the spout, as a result of the engagement between the container and the engagement part.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 14, 2020
    Inventors: Hiroaki KANO, Kotaro KAWANO, Masaaki MURAKAMI
  • Publication number: 20200049696
    Abstract: [Problem] The objectives of the present invention are to provide a method for making an animal that has been stressed, in particular, chronically stressed, affect or develop a specific disease or symptom, and, through elucidating the process from loading stress to affection or onset of the disease or symptom, to provide a useful tool for research and development of preventing or treating methods of the disease or symptom. [Solution] The present invention relates to a method for producing a disease modeling non-human animal having cerebrovascular inflammation, the disease modeling non-human animal, a method for screening a drug using the disease modeling non-human animal, a method for determining the risk of a disease using the presence of cerebrovascular inflammation as an indicator, and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like.
    Type: Application
    Filed: March 1, 2018
    Publication date: February 13, 2020
    Applicant: National University Corporation Hokkaido University
    Inventors: Masaaki Murakami, Daisuke Kamimura, Yasunobu Arima
  • Patent number: 9453482
    Abstract: Provide is a construction machine allowing an air cleaner to be located entirely low while securing dust-discharge function thereof, with no risk of adverse effects such as diffusion of dusts and complication in structure. The construction machine includes an engine and an air cleaner connected to an intake-side portion of the engine to filter intake air. The air cleaner includes an air-cleaner main body which filters the intake air and an evacuator which discharges dusts separated from the intake air and protrudes downward beyond the air-cleaner main body. The air-cleaner main body is placed on an air-cleaner placement surface, the evacuator protruding downward beyond the air-cleaner placement surface at a position deviated outward from the air-cleaner placement surface.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: September 27, 2016
    Assignee: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Jumpei Yokota, Masaaki Murakami, Tomotaka Kita, Yoshihiko Ueda
  • Patent number: 9428882
    Abstract: Provided is a construction machine having a central foothold and a maintenance access passage with high safety. The construction machine includes an upper slewing body including: an upper frame, an engine compartment, a cabin on a right or left region of the upper frame, a central foothold immediately forward of the engine compartment and on a central region of the upper frame widthwise of the upper frame, and a maintenance access passage extending rearward while elevated to guide a worker from the ground forward of the upper frame to the central foothold on a side opposite to the cabin. Widthwise of the upper frame, an inward edge of an upper end portion of the maintenance access passage is located inward of one edge of the central foothold, to thereby form a transit zone between the maintenance access passage and the central foothold.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: August 30, 2016
    Assignee: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Masaaki Murakami, Hironori Tsukamoto, Tsuyoshi Noda
  • Patent number: 9212466
    Abstract: Provided is a construction machine including: an upper slewing body including an upper frame; an engine room on the rear portion of the upper frame; a cabin on the front portion on the right or left side of the upper frame; a plurality of tanks including a fuel tank and a hydraulic tank installed on the upper frame; an air cleaner; a center foothold on the intermediate portion in the width direction of the upper frame and forward of the engine room; and a climbing step at the opposite side to the cabin. A first tank of the plurality of tanks is placed on a portion on the right or left side of the upper frame, and a second tank is arranged on a portion between the cabin and the engine room on the opposite side to the first tank. The air cleaner is superposed on the second tank.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: December 15, 2015
    Assignee: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Jumpei Yokota, Masaaki Murakami, Tomotaka Kita, Yoshihiko Ueda
  • Publication number: 20150176245
    Abstract: Provided is a construction machine having a central foothold and a maintenance access passage with high safety. The construction machine includes an upper slewing body including: an upper frame, an engine compartment, a cabin on a right or left region of the upper frame, a central foothold immediately forward of the engine compartment and on a central region of the upper frame widthwise of the upper frame, and a maintenance access passage extending rearward while elevated to guide a worker from the ground forward of the upper frame to the central foothold on a side opposite to the cabin. Widthwise of the upper frame, an inward edge of an upper end portion of the maintenance access passage is located inward of one edge of the central foothold, to thereby form a transit zone between the maintenance access passage and the central foothold.
    Type: Application
    Filed: December 4, 2014
    Publication date: June 25, 2015
    Applicant: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Masaaki MURAKAMI, Hironori TSUKAMOTO, Tsuyoshi NODA
  • Publication number: 20150136503
    Abstract: Provide is a construction machine allowing an air cleaner to be located entirely low while securing dust-discharge function thereof, with no risk of adverse effects such as diffusion of dusts and complication in structure. The construction machine includes an engine and an air cleaner connected to an intake-side portion of the engine to filter intake air. The air cleaner includes an air-cleaner main body which filters the intake air and an evacuator which discharges dusts separated from the intake air and protrudes downward beyond the air-cleaner main body. The air-cleaner main body is placed on an air-cleaner placement surface, the evacuator protruding downward beyond the air-cleaner placement surface at a position deviated outward from the air-cleaner placement surface.
    Type: Application
    Filed: October 22, 2014
    Publication date: May 21, 2015
    Applicant: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Jumpei Yokota, Masaaki Murakami, Tomotaka Kita, Yoshihiko Ueda
  • Publication number: 20150136502
    Abstract: Provided is a construction machine including: an upper slewing body including an upper frame; an engine room on the rear portion of the upper frame; a cabin on the front portion on the right or left side of the upper frame; a plurality of tanks including a fuel tank and a hydraulic tank installed on the upper frame; an air cleaner; a center foothold on the intermediate portion in the width direction of the upper frame and forward of the engine room; and a climbing step at the opposite side to the cabin. A first tank of the plurality of tanks is placed on a portion on the right or left side of the upper frame, and a second tank is arranged on a portion between the cabin and the engine room on the opposite side to the first tank. The air cleaner is superposed on the second tank.
    Type: Application
    Filed: October 22, 2014
    Publication date: May 21, 2015
    Applicant: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Jumpei YOKOTA, Masaaki MURAKAMI, Tomotaka KITA, Yoshihiko UEDA
  • Patent number: 8661793
    Abstract: A construction machine including an engine, a fuel tank, and a liquid reductant tank. The construction machine further includes a tank cover, and the fuel tank has an upper surface including a high-position surface and a low-position surface located at a lower position than the high-position surface and adjacent to the high-position surface through a step. The tank cover is provided over the low-position surface and at a height position approximately equal to that of the high-position surface to define a liquid reductant tank installation space in cooperation with the low-position surface. The liquid reductant tank has a replenishment port, installed in the liquid reductant tank installation space so that the replenishment port is close to a lower surface of the tank cover.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: March 4, 2014
    Assignee: Kobelco Construction Machinery Co., Ltd.
    Inventors: Koji Yamashita, Masaaki Murakami, Takayuki Okunishi
  • Publication number: 20130236473
    Abstract: A major object of the present invention is to provide a novel therapeutic or prophylactic agent for at least one disease or symptom selected from the group consisting of autoimmune diseases, inflammatory diseases, allergic diseases, and symptoms accompanying organ transplants; the therapeutic or prophylactic agent artificially controls the activity of IL-6 amplifier, thus controlling immune reactions in living organisms. Another object of the present invention is to provide an immunosuppressant, an inflammatory cytokine production inhibitor, and an IL-6 amplifier inhibitor. The compound that inhibits expression of the function of a protein belonging to ErbB1 pathway provided as means for achieving the object is capable of suppressing the activity of IL-6 amplifier, thereby reducing production of inflammatory cytokine such as IL-6.
    Type: Application
    Filed: September 14, 2011
    Publication date: September 12, 2013
    Applicant: OSAKA UNIVERSITY
    Inventors: Toshio Hirano, Masaaki Murakami
  • Patent number: D725157
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: March 24, 2015
    Assignee: Kobelco Construction Machinery Co., Ltd.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Jumpei Yokota, Daisuke Mochizuki, Hironori Tsukamoto, Tsuyoshi Noda, Hiroshi Kanamaru, Kaoru Adachi
  • Patent number: D726779
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: April 14, 2015
    Assignee: Kobelco Construction Machinery Co., Ltd.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Jumpei Yokota, Daisuke Mochizuki, Hironori Tsukamoto, Tsuyoshi Noda, Hiroshi Kanamaru, Kaoru Adachi
  • Patent number: D727977
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: April 28, 2015
    Assignee: Kobelco Construction Machinery Co., Ltd.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Jumpei Yokota, Daisuke Mochizuki, Hironori Tsukamoto, Tsuyoshi Noda, Hiroshi Kanamaru, Kaoru Adachi
  • Patent number: D727978
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: April 28, 2015
    Assignee: Kobelco Construction Machinery Co., Ltd.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Koji Fujikawa, Masaru Ito
  • Patent number: D730948
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: June 2, 2015
    Assignee: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Koji Fujikawa, Masaru Ito
  • Patent number: D759127
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: June 14, 2016
    Assignee: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Jumpei Yokota, Daisuke Mochizuki, Hironori Tsukamoto, Tsuyoshi Noda, Hiroshi Kanamaru, Kaoru Adachi
  • Patent number: D778962
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: February 14, 2017
    Assignee: KOBELCO CONSTRUCTION MACHINERY CO., LTD.
    Inventors: Fumikazu Higuchi, Masaaki Murakami, Jumpei Yokota, Daisuke Mochizuki, Hironori Tsukamoto, Tsuyoshi Noda, Hiroshi Kanamaru, Kaoru Adachi