Abstract: A position obtaining device includes a processor. The processor, in response to a condition being met, derives a first attitude angle as an attitude angle of the device based on first light sources and positions thereof on an image obtained by a first camera; in response to the attitude angle of the device being known, derives a three-dimensional position of the device based on two or more second light sources and positions thereof on an image obtained by a second camera, and in response to a predetermined number of second light sources or more being captured in the image, derives the three-dimensional position and a second attitude angle as the attitude angle of the device; and integrates a result of the first attitude angle and a result of the three-dimensional position and the second attitude angle to estimate the attitude angle and the three-dimensional position of the device.

Abstract: This ultrasonic-wave vibration imparting device is configured so as to be attachable to a container that retains a beverage and that has a spout on an upper part thereof. The ultrasonic-wave vibration imparting device includes: an annular engagement part configured so as to engage with the upper part of the container; and an ultrasonic wave generating unit configured so as to be disposed at a position at which the unit comes into contact with a side surface of the container below the spout, as a result of the engagement between the container and the engagement part.

Abstract: [Problem] The objectives of the present invention are to provide a method for making an animal that has been stressed, in particular, chronically stressed, affect or develop a specific disease or symptom, and, through elucidating the process from loading stress to affection or onset of the disease or symptom, to provide a useful tool for research and development of preventing or treating methods of the disease or symptom. [Solution] The present invention relates to a method for producing a disease modeling non-human animal having cerebrovascular inflammation, the disease modeling non-human animal, a method for screening a drug using the disease modeling non-human animal, a method for determining the risk of a disease using the presence of cerebrovascular inflammation as an indicator, and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like.

Abstract: The present invention provides a method for assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease in a test subject, by using, as an indicator, the level of SYT17 protein in a urine-derived specimen collected from the test subject. The present invention also provides: a pharmaceutical composition for preventing and/or treating chronic kidney allograft rejection or chronic kidney disease, the pharmaceutical composition including at least one substance selected from the group consisting of a specific antibody to SYT17, a derivative of the specific antibody, and an inhibitory nucleic acid against SYT17; and a test kit for use in assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease, the test kit including a specific antibody to SYT17 or a derivative of the specific antibody.

Abstract: A fan-equipped heatsink includes: a heat receiving substrate made of metal; a centrifugal fan disposed on an upper surface side of the heat receiving substrate; a plate-shaped wall that is made of metal, is provided so as to stand at a position, on the upper surface of the heat receiving substrate, which is around and opposed to an outer peripheral portion having an air discharge opening of the centrifugal fan, and are provided with a plurality of through-holes that are open in a plate surface opposed to the centrifugal fan; and a lid member fixed to an upper end of the plate-shaped wall 4 and configured to close a space on the inner side of the plate-shaped wall.

Abstract: The present invention pertains to a medicine, said medicine comprising as an active ingredient a substance which suppresses the expression of at least one molecule selected from the group consisting of TMEM5, VSTM2L, C2CDD4D, VSTM2A, LY6G6C and ADRA2C or inhibits the activity thereof, for preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death. Also, the present invention pertains to a method for screening a substance, which is capable of preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death, with the use of the expression or activity of the aforesaid molecule as an index.

Abstract: A fan-equipped heatsink includes: a heat receiving substrate made of metal; a centrifugal fan disposed on an upper surface side of the heat receiving substrate; a plate-shaped wall that is made of metal, is provided so as to stand at a position, on the upper surface of the heat receiving substrate, which is around and opposed to an outer peripheral portion having an air discharge opening of the centrifugal fan, and are provided with a plurality of through-holes that are open in a plate surface opposed to the centrifugal fan; and a lid member fixed to an upper end of the plate-shaped wall 4 and configured to close a space on the inner side of the plate-shaped wall.

Abstract: [Problem] The purpose of the present invention is to provide new treatment targets and treatment methods for chronic inflammatory disease based on a molecular biological mechanism relating to the onset of keloid. [Solution] The present invention relates to a drug for the prevention and/or treatment of chronic inflammatory disease that contains as an active ingredient a substance that suppresses the expression and/or inhibits the activity of a specific NEDD4 splicing variant protein.

Abstract: This ultrasonic-wave vibration imparting device is configured so as to be attachable to a container that retains a beverage and that has a spout on an upper part thereof. The ultrasonic-wave vibration imparting device includes: an annular engagement part configured so as to engage with the upper part of the container; and an ultrasonic wave generating unit configured so as to be disposed at a position at which the unit comes into contact with a side surface of the container below the spout, as a result of the engagement between the container and the engagement part.

Abstract: [Problem] The objectives of the present invention are to provide a method for making an animal that has been stressed, in particular, chronically stressed, affect or develop a specific disease or symptom, and, through elucidating the process from loading stress to affection or onset of the disease or symptom, to provide a useful tool for research and development of preventing or treating methods of the disease or symptom. [Solution] The present invention relates to a method for producing a disease modeling non-human animal having cerebrovascular inflammation, the disease modeling non-human animal, a method for screening a drug using the disease modeling non-human animal, a method for determining the risk of a disease using the presence of cerebrovascular inflammation as an indicator, and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like.

Abstract: Provide is a construction machine allowing an air cleaner to be located entirely low while securing dust-discharge function thereof, with no risk of adverse effects such as diffusion of dusts and complication in structure. The construction machine includes an engine and an air cleaner connected to an intake-side portion of the engine to filter intake air. The air cleaner includes an air-cleaner main body which filters the intake air and an evacuator which discharges dusts separated from the intake air and protrudes downward beyond the air-cleaner main body. The air-cleaner main body is placed on an air-cleaner placement surface, the evacuator protruding downward beyond the air-cleaner placement surface at a position deviated outward from the air-cleaner placement surface.

Abstract: Provided is a construction machine having a central foothold and a maintenance access passage with high safety. The construction machine includes an upper slewing body including: an upper frame, an engine compartment, a cabin on a right or left region of the upper frame, a central foothold immediately forward of the engine compartment and on a central region of the upper frame widthwise of the upper frame, and a maintenance access passage extending rearward while elevated to guide a worker from the ground forward of the upper frame to the central foothold on a side opposite to the cabin. Widthwise of the upper frame, an inward edge of an upper end portion of the maintenance access passage is located inward of one edge of the central foothold, to thereby form a transit zone between the maintenance access passage and the central foothold.

Abstract: Provided is a construction machine including: an upper slewing body including an upper frame; an engine room on the rear portion of the upper frame; a cabin on the front portion on the right or left side of the upper frame; a plurality of tanks including a fuel tank and a hydraulic tank installed on the upper frame; an air cleaner; a center foothold on the intermediate portion in the width direction of the upper frame and forward of the engine room; and a climbing step at the opposite side to the cabin. A first tank of the plurality of tanks is placed on a portion on the right or left side of the upper frame, and a second tank is arranged on a portion between the cabin and the engine room on the opposite side to the first tank. The air cleaner is superposed on the second tank.

Abstract: Provided is a construction machine having a central foothold and a maintenance access passage with high safety. The construction machine includes an upper slewing body including: an upper frame, an engine compartment, a cabin on a right or left region of the upper frame, a central foothold immediately forward of the engine compartment and on a central region of the upper frame widthwise of the upper frame, and a maintenance access passage extending rearward while elevated to guide a worker from the ground forward of the upper frame to the central foothold on a side opposite to the cabin. Widthwise of the upper frame, an inward edge of an upper end portion of the maintenance access passage is located inward of one edge of the central foothold, to thereby form a transit zone between the maintenance access passage and the central foothold.

Abstract: Provide is a construction machine allowing an air cleaner to be located entirely low while securing dust-discharge function thereof, with no risk of adverse effects such as diffusion of dusts and complication in structure. The construction machine includes an engine and an air cleaner connected to an intake-side portion of the engine to filter intake air. The air cleaner includes an air-cleaner main body which filters the intake air and an evacuator which discharges dusts separated from the intake air and protrudes downward beyond the air-cleaner main body. The air-cleaner main body is placed on an air-cleaner placement surface, the evacuator protruding downward beyond the air-cleaner placement surface at a position deviated outward from the air-cleaner placement surface.

Abstract: Provided is a construction machine including: an upper slewing body including an upper frame; an engine room on the rear portion of the upper frame; a cabin on the front portion on the right or left side of the upper frame; a plurality of tanks including a fuel tank and a hydraulic tank installed on the upper frame; an air cleaner; a center foothold on the intermediate portion in the width direction of the upper frame and forward of the engine room; and a climbing step at the opposite side to the cabin. A first tank of the plurality of tanks is placed on a portion on the right or left side of the upper frame, and a second tank is arranged on a portion between the cabin and the engine room on the opposite side to the first tank. The air cleaner is superposed on the second tank.