Patents by Inventor Masaaki Shimagaki
Masaaki Shimagaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190309245Abstract: A sealable vessel for cell isolation, culture and proliferation comprising a cell separation unit, comprising a cell separation membrane having fine pores capable of isolating cells; a primary culture unit, having a culture surface on which cells having passed through the cell separation membrane can be cultured and a releasing structure through which cells and a liquid held inside the primary culture unit can be freely released toward a unit having a culture surface for a subsequent step; and a main vessel unit, having a culture surface for cell proliferation on which cells that have been released from a culture unit for a preceding step can be cultured, the main vessel unit having a structure in which the cell separation unit and all of the culture unit/units for preceding step/steps can be stored.Type: ApplicationFiled: December 24, 2016Publication date: October 10, 2019Inventors: Masaaki Shimagaki, Kosho Suzuki, Yusuke Atsumi, Misako Nakashima
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Patent number: 9687794Abstract: A polysulfone-based hollow fiber membrane that purifies blood preparations, including a hydrophilic polymer on a surface thereof which contacts the blood preparation, wherein an abundance ratio of the hydrophilic polymer is from 40 to 60% by mass, and porosity at the surface is 8 to 30%.Type: GrantFiled: March 28, 2013Date of Patent: June 27, 2017Assignee: Toray Industries, Inc.Inventors: Masahiro Osabe, Tatsuya Kishikawa, Yoshiyuki Ueno, Masaaki Shimagaki
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Patent number: 9446074Abstract: A method of producing a platelet solution replaced with an artificial preservation solution includes a filtering step of carrying out cross-flow filtration of a platelet solution under the conditions of Formula (1) at an inlet wall shear rate of 25 to 1500 s?1 using a separation membrane whose surface which contacts with the platelet solution has an average pore size of not less than 0.1 ?m and less than 2.0 ?m, thereby obtaining a concentrated platelet solution; and a mixing step of mixing the concentrated platelet solution with an artificial preservation solution to obtain the platelet solution replaced with an artificial preservation solution: 1.0×1011<(A×B)/(?×?P)?2.5×1013 (platelets/(hr·m2·Pa))??(1) A: Concentration of platelets contained in the platelet solution (platelets/mL; with the proviso that the range is 8.0×107 to 200×107 platelets/mL) B: Filtration flow rate per unit area (mL/hr/m2) ?: Inlet wall shear rate (s?1) ?P: Viscosity of the platelet solution (Pa·s).Type: GrantFiled: November 27, 2013Date of Patent: September 20, 2016Assignee: Toray Industries, Inc.Inventors: Tatsuya Kishikawa, Masahiro Osabe, Yoshiyuki Ueno, Masaaki Shimagaki, Shigenori Tanaka, Tomoya Hayashi
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Publication number: 20150313943Abstract: A method of producing a platelet solution replaced with an artificial preservation solution includes a filtering step of carrying out cross-flow filtration of a platelet solution under the conditions of Formula (1) at an inlet wall shear rate of 25 to 1500 s?1 using a separation membrane whose surface which contacts with the platelet solution has an average pore size of not less than 0.1 ?m and less than 2.0 ?m, thereby obtaining a concentrated platelet solution; and a mixing step of mixing the concentrated platelet solution with an artificial preservation solution to obtain the platelet solution replaced with an artificial preservation solution: 1.0×1011<(A×B)/(?×?P)?2.5×1013 (platelets/(hr·m2·Pa))??(1) A: Concentration of platelets contained in the platelet solution (platelets/mL; with the proviso that the range is 8.0×107 to 200×107 platelets/mL) B: Filtration flow rate per unit area (mL/hr/m2) ?: Inlet wall shear rate (s?1) ?P: Viscosity of the platelet solution (Pa·s).Type: ApplicationFiled: November 27, 2013Publication date: November 5, 2015Inventors: Tatsuya Kishikawa, Masahiro Osabe, Yoshiyuki Ueno, Masaaki Shimagaki, Shigenori Tanaka, Tomoya Hayashi
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Publication number: 20150053609Abstract: A polysulfone-based hollow fiber membrane that purifies blood preparations, including a hydrophilic polymer on a surface thereof which contacts the blood preparation, wherein an abundance ratio of the hydrophilic polymer is from 40 to 60% by mass, and porosity at the surface is 8 to 30%.Type: ApplicationFiled: March 28, 2013Publication date: February 26, 2015Applicant: Toray Industries, Inc.Inventors: Masahiro Osabe, Tatsuya Kishikawa, Yoshiyuki Ueno, Masaaki Shimagaki
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Patent number: 8932590Abstract: An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor ? which is combined with another protein, includes adsorbing the transforming growth factor ? and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.Type: GrantFiled: June 15, 2011Date of Patent: January 13, 2015Assignee: TORAY Industries, Inc.Inventors: Kazuo Teramoto, Toshio Yoshioka, Masaaki Shimagaki, Takeo Matsunase, Koji Watanabe, Yuji Ueda, Yoshiki Yamamoto
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Publication number: 20140178992Abstract: A membrane separation culture device includes an upper structure including a vessel in which at least a portion of the bottom thereof is formed with a separation membrane having pores that allow stem cells to permeate therethrough, and a lower structure including a vessel that retains a fluid in which the membrane of the upper structure is immersed.Type: ApplicationFiled: March 30, 2012Publication date: June 26, 2014Applicant: National Center for Geriatrics and GerontologyInventors: Misako Nakashima, Koichiro Iohara, Kazumasa Yamada, Masaaki Shimagaki, Masahiro Osabe
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Patent number: 8584869Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.Type: GrantFiled: March 31, 2006Date of Patent: November 19, 2013Assignee: Toray Industries, Inc.Inventors: Masaaki Shimagaki, Yasufumi Yamamura, Katsuhisa Sato, Kazuo Teramoto, Takeshige Oozeki, Shigehisa Wada
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Publication number: 20110240560Abstract: An adsorbent for immunosuppressive substance, which can adsorb an excessive immunosuppressive substance directly from a body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. The excessive immunosuppressive substance may be involved in growth of cancer cells. The adsorbent for immunosuppressive substance includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column contains the adsorbent of the invention. A method for treating cancer carries out extracorporeal perfusion using the extracorporeal perfusion column. A method of adsorbing the transforming growth factor ? which is combined with another protein, includes adsorbing the transforming growth factor ? and protein on an adsorbent containing a water-insoluble carrier to which quaternary ammonium groups each having 3 to 18 carbon atoms per one nitrogen atom are attached, and having a specific surface area of 0.Type: ApplicationFiled: June 15, 2011Publication date: October 6, 2011Inventors: Kazuo Teramoto, Toshio Yoshioka, Masaaki Shimagaki, Takeo Matsunase, Koji Watanabe, Yuji Ueda, Yoshiki Yamamoto
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Publication number: 20100297202Abstract: Disclosed is an aqueous dispersion containing polysaccharide particulate gels, which is characterized by containing particulate gels substantially composed of a polysaccharide. The aqueous dispersion containing polysaccharide particulate gels is also characterized in that shapes of the particulate gels are maintained even after the particulate gels are heated for 30 minutes at 95° C. in an aqueous medium. Namely, disclosed is an aqueous dispersion containing polysaccharide particulate gels, wherein the particulate gels are composed of a polysaccharide and have shapes that can be maintained even after 30-minute heating in an aqueous medium of 95° C.Type: ApplicationFiled: February 5, 2009Publication date: November 25, 2010Inventors: Hiroto Okumura, Masaaki Shimagaki, Takashi Taniguchi
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Publication number: 20100270232Abstract: A fiber construct for treating biological components, including fibers having an average diameter of less than 50 ?m, wherein at least some of the fibers are crimped.Type: ApplicationFiled: December 26, 2008Publication date: October 28, 2010Applicant: TORAY INDUSTRIES, INC.Inventors: Ema Iwanaga, Masaaki Shimagaki
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Publication number: 20100176051Abstract: An adsorption carrier includes fibers A having a diameter of 0.5 or more to 8 ?m or less and fibers B having a diameter of 8 ?m or more to 50 ?m or less, the fibers B having a larger diameter than the fibers A, and the fibers B being sheath-core or islands-in-sea composite fibers.Type: ApplicationFiled: August 30, 2007Publication date: July 15, 2010Applicant: Toray Industries, Inc., a corporation of JapanInventor: Masaaki Shimagaki
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Publication number: 20090275874Abstract: The present invention provides an absorbent which can remove cells present in blood including activated leukocytes such as granulocytes and monocytes, and cancer cells as well as can remove cytokines which facilitate the activation of the remaining cells, and further has no concern for pressure loss and has high configuration stability. That is, the present invention provides an absorbent which absorbs the granulocytes and the monocytes in blood, an absorbent for cancer therapy which absorbs an immunosuppressive protein and an absorbent having a bilayer structure of a net and a nonwoven fabric, having a zeta potential of ?20 mV or more, as well as a blood circulation column containing any of the absorbents filled therein.Type: ApplicationFiled: March 31, 2006Publication date: November 5, 2009Applicant: TORAY INDUSTRIES, INC.Inventors: Masaaki Shimagaki, Yasufumi Yamamura, Katsuhisa Sato, Kazuo Teramoto, Takeshige Oozeki, Shigehisa Wada
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Publication number: 20060165647Abstract: An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.Type: ApplicationFiled: April 3, 2003Publication date: July 27, 2006Inventors: Kazuo Teramoto, Toshio Yoshioka, Masaaki Shimagaki, Takeo Matsunase, Koji Watanabe, Yuji Ueda, Yoshiki Yamamoto
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Patent number: 6953388Abstract: A polishing pad characterized by having a mechanism for supplying water to the plane of the polishing pad in contact with the article to be polished, in particular, in case the mechanism comprises a domain structure having an area of 1×10?6 m2 or smaller, reduces the generation of scratches and the dust adhesion on the surface of the article to be polished, while increasing polishing rate at low dishing and erosion; hence, the product is applicable to the field of surface polishing of semiconductor thin films.Type: GrantFiled: December 18, 2000Date of Patent: October 11, 2005Assignee: Toray Industries, Inc.Inventors: Masaaki Shimagaki, Hisashi Minamiguchi, Masami Ohta
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Publication number: 20030003857Abstract: A polishing pad characterized by having a mechanism for supplying water to the plane of the polishing pad in contact with the article to be polished, in particular, in case the mechanism comprises a domain structure having an area of 1×10−6 m2 or smaller, reduces the generation of scratches and the dust adhesion on the surface of the article to be polished, while increasing polishing rate at low dishing and erosion; hence, the product is applicable to the field of surface polishing of semiconductor thin films.Type: ApplicationFiled: June 21, 2002Publication date: January 2, 2003Inventors: Masaaki Shimagaki, Hisashi Minamiguchi, Masami Ohta
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Patent number: 6103117Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have:(1) per membrane area of 1.8 m.sup.2, in vitro clearances for urea and phosphorus respectively of .gtoreq.195, and .gtoreq.180, ml/min, a .beta..sub.2 -microglobulin clearance .gtoreq.44 ml/min and an albumin permeability .ltoreq.0.5%;(2) an albumin permeability .ltoreq.1.5% and an overall mass transfer coefficient Ko .gtoreq.0.0012 cm/min; and(3) a vitamin B.sub.12 dialyzance of .gtoreq.135 ml/min and an albumin permeability .ltoreq.3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree. C. of 25-130 poise and a quantity y % of water given by:-0.01x+1.45.ltoreq.y.ltoreq.-0.01x+2.Type: GrantFiled: February 23, 1999Date of Patent: August 15, 2000Assignee: Toray Industries, Inc.Inventors: Masaaki Shimagaki, Fumiaki Fukui, Takeshi Sonoda, Koji Sugita
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Patent number: 5938929Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have:(1) per membrane area of 1.6 m.sup.2, in vitro clearances for urea and phosphorus respectively of .gtoreq.195, and .gtoreq.180, ml/min, a .beta..sub.2 -microglobulin clearance .gtoreq.44 ml/min and an albumin permeability .ltoreq.0.5%;(2) an albumin permeability .ltoreq.1.5% and an overall mass transfer coefficient Ko.gtoreq.0.0012 cm/min; and(3) a vitamin B.sub.12 dialyzance of .gtoreq.135 ml/min and an albumin permeability .ltoreq.3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree. C. of 25-130 poise and a quantity y % of water given by:-0.01x+1.45.ltoreq.y.ltoreq.-0.01x+2.25.Type: GrantFiled: June 28, 1996Date of Patent: August 17, 1999Assignee: Toray Industries, Inc.Inventors: Masaaki Shimagaki, Fumiaki Fukui, Takeshi Sonoda, Koji Sugita